Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 150 for “"Normal tissues"”.
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Modeling of [¹⁸F]-FHBG in tumor and normal tissues
The development of new, non-invasive approaches for the treatment of tumors has led to the emergence of oncolytic virus therapy. Viruses have been engineered to preferentially target tumor cells. The efficiency and safety of this cancer treatment is dependent upon selective viral replication within …
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Somatic mutagenesis in humans with deficient DNA repair
The accumulation of mutations in normal cells causes the development of cancer and is implicated as a potential mechanism in the physiological process of ageing. In recent years our ability to interrogate the genome of human cancers and the normal tissues from which they arise has expanded greatly. …
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Investigating the fibroblast activation protein alpha expressing stromal cell in a spontaneous murine model of pancreatic adenocarcinoma
… shown that FAP+ cells are widely distributed in normal tissues. FAP+ cells were sorted from PDA and several normal tissues for RNA-seq analysis. The transcriptomic data suggests that FAP+ cells in normal tissues are highly similar: FAP+ cells in PDA are related but form a distinct subset. Of …
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Investigating the potential of the Metastasis Associated Antigen 1 (MTA1) for cancer immunotherapy in a murine model
… in most of the tumour cell lines as compared to normal tissues, which express mMTA1 at very low levels. Furthermore, to rule out any post-transcriptional modifications, MTA1 protein levels were also confirmed by western blotting. It was observed that most of the cell lines expressed MTA1 at high …
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The effects of dietary lipids on the fatty acid composition of tissue and membrane fractions of spontaneous mammary adenocarcinomas and mammary glands of Strong strain A mice
… fractions of mammary adenocarcinomas and normal mammary glands excised from Strong A female mice fed a 15% safflower oil and 15% tallow diets were studied. Previous work has indicated that high fat diets in general and high unsaturated fat diets in particular, influenced tumorigenesis. The …
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Detection of Single Nucleotide Polymorphisms In Csmd1 Gene of Colon and Breast Cancer Patients
… in the CSMD1 gene of either tumor or matched normal tissues of 80 unrelated patients (30 colon cancer, 50 breast cancers). More than 92% of the 165 SNPs detected were present in the normal tissues. One non synonymous SNP found at an amino acid position 2772 in exon 55 of CSMD1 gene of a stage …
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An analysis of the periodicity of the cell cycle and apoptotic regulatory proteins in prostate xenografts using anova and cosinor methods
… have been found in both plants and animals, in normal tissues as well as in most tumors and human cancers. By following these rhythms in healthy and cancerous tissue, it has been possible to find optimal times to deliver a dose of drug, such that efficacy is maximized and toxicity to normal …
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The role of proteases in development of cancer in mice
… in protease activity in tumour bearing and in normal tissues such as lung, liver and skelatal muscle. Using a modified fluorescent assay, differences in m-calpain and calpastatin activity were found between seven and nine month ethyl carbamate treated mice. The calpain to calpastatin ratio is …
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Pharmacological investigations into matrix metalloproteinase-activated anti-tumour prodrugs. In vitro metabolic and pharmacological investigations into a series of colchicine-based peptide prodrugs activated by tumour-expressed matrix metalloproteinases
… of matrix metalloproteinases in tumour tissues relative to normal tissues has been exploited as a target for peptide-based therapeutics, to improve therapeutic index of currently used agents. The stability of MMP-activated prodrugs in normal tissue or organs is a significant challenge …
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Mutational processes in normal human tissues
… of understanding patterns of somatic mutation in normal cells. This accumulation of somatic mutations is shaped by numerous mutational processes, each generating a distinctive profile of mutations, called a ‘mutational signature’. From mutational signatures, one can infer a history of operating …
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Regulation of CYP3A5 in Pancreatic Ductal Adenocarcinoma
… enzyme that is polymorphically expressed in normal tissues and expressed in high amounts in some cancers, including pancreatic ductal adenocarcinoma (PDAC). There have been several published studies regarding CYP3A5 regulators, but there is still much to be discovered concerning CYP3A5 …
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Systemic analysis of changes in protein modification and gene coexpression networks in cancer
… also curates gene expression data from tumor and normal tissues, enabling us to calculate gene coexpression networks and apply graph algorithms in Neo4j.
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Computer-Aided Detection of Pathologically Enlarged Lymph Nodes On Non-Contrast Ct In Cervical Cancer Patients For Low-Resource Settings
… to distinguish potential positive nodes from normal structures. Regions on adjacent slices were then connected into a potential nodal 3D-structure. To differentiate these 3D structures from normal tissues, eighty-six features were generated based on the shape and mean pixel values of the …
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Auto-Delineation of Oropharyngeal Clinical Target Volumes Using Deep Learning Techniques
… target dose distribution and better sparing of normal tissues. However, producing very precise treatment plans may be ineffective if the target volumes are not defined accurately. Furthermore, there are several reports of significant inter-observer variability when delineating these target …
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Applications of Voronoi partitions in particle therapy
… tumors and improved sparing of surrounding normal tissues and critical structures. Many challenging and interesting mathematical optimization problems arise in the planning of charged particle radiation therapy. In this thesis, we study three important optimization problems in particle …
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Phylogenetic studies into the development of foetal tissues and their neoplastic derivatives
… strategy for optimising survival. Studies into normal and neoplastic tissues in adults have delineated clonal architecture and oncogenesis at an exquisite resolution. However, for over a century, data have indicated that childhood cancer is rather different, most likely emerging as an aberration …
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Evaluation of potential photodynamic therapy agents and patient-relevant biomarker combinations for the selective targeting of cancer
… is characterized by uncontrolled and abnormal cell growth. Even though researchers have made significant progress in its treatment over the past several decades, innovative therapeutic approaches that both improve patient survival and lessen the many debilitating side effects of …
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Studies on the Application of Multiwalled Carbon Nanotubes for the Thermal Treatment of Cancer
… nanomedicines, chiefly: their compatibility with normal tissues and their efficacy as therapeutic agents. In this thesis we investigated these aspects of the biomedical translation of carbon nanotubes (CNTs) through three aims: 1) To determine the role of chemical modifications in mediating blood …
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Defining sources of nutrient limitation for tumors
… accessibility in tumors is different than in normal tissues. Thus, tumor survival and growth may be limited by different metabolic factors than those that are necessary to maintain non-cancerous cells. This dissertation examines sources of nutrient limitation in tumors. We study the role of …
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