Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 221 for “"Normal tissue"”.
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Understanding normal-tissue late effects in the intestines after pelvic radiotherapy
… other treatments. The photons must pass through normal tissue to converge on the tumor, and it is unavoidable that radiotherapy causes acute as well as late adverse effects. Roughly one million cancer survivors in Europe are suffering from radiation-induced intestinal symptoms, such as urgency to …
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Identifying Image Derived Features of Radiation Therapy Response: Tumor and Normal Tissue
… of tumors and detection of radiation-induced normal tissue injury. Using preclinical models, quantitative image features will be mined from MR and PET scans in radioresponsive and radioresistant tumors to establish universal and tumor-specific imaging markers of treatment response. Furthermore …
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Effects of Advanced Radiotherapy techniques on Normal Tissue Toxicity in Breast Cancer
… with some long-term side effects and breast tissue toxicities including breast shrinkage, breast fibrosis, skin changes and poor overall cosmesis. These breast-specific complications can have a detrimental psychological impact. New radiotherapy techniques including IMRT and IGRT have the …
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Assessment of Collimator Jaw Optimization In Reducing Normal Tissue Irradiation With Intensity Modulated Radiation Therapy
<p><strong>Purpose:</strong> To evaluate normal tissue dose reduction in step-and-shoot intensity-modulated radiation therapy (IMRT) on the Varian 2100 platform by tracking the multileaf collimator (MLC) apertures with the accelerator jaws.</p> <p><strong>Methods: </strong>Clinical radiation …
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Dosimetric comparison of volumetric modulated arc therapy and three dimensional conformal radiotherapy in the adjuvant setting for the management of gastric cancer : target volume coverage and normal tissue sparing
Whilst the benefit of adjuvant radiotherapy in gastric cancer is known, the optimal means of delivery, including two dimensional conventional, three dimensional conformal radiotherapy, intensity modulated radiotherapy and volumetric modulated arc therapy is less certain. The purpose of this study …
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Car-Modified T Cells Capable of Distinguishing Normal Cells From Malignant Cells
… cells. Due to the potential for on-target, off-tissue toxicity, CAR<sup>+</sup> T-cell therapy is currently limited to unique or lineage-restricted TAAs. Glioblastoma, a grade IV brain malignancy, overexpresses epidermal growth factor receptor (EGFR) in 40-50% of patients. EGFR also has …
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4D Study of Thoracic Cancer Radiation Treatment
… thoracic malignancies due to an increase in the normal tissue irradiated and an uncertainty in the radiation coverage of the tumor. This results in a potential increase in complications from treatment and may be insufficient to ensure coverage of the tumor. Reduction of the volume of normal …
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NQO1-Bioactivatable Drugs at the Interface of Cancer Metabolism and the DNA Damage Response
… ROS protection, to ROS production while sparing normal tissue from toxicity. The phase II detoxification enzyme, NAD(P)H:quinone oxidoreductase-1, NQO1, is dramatically overexpressed in many solid tumor types, including pancreatic ductal adenocarcinoma (PDA) and non-small cell lung cancer …
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Implementation,Validation and Application of an Automated Motion Correction Algorithm in Hepatic Perfusion CT for Image-Guided Radiotherapy
… determine impact of motion correction on tumour-normal tissue contrast. The motion corrected perfusion maps were used in a radiotherapy target volume delineation study. Three observers delineated tumours on perfusion images and standard contrast enhanced 4D-CT scans. Interobserver concordance was …
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Late Effects of Ionizing Radiation on Normal Microvascular Networks
… and function of microvascular networks in normal tissue. Previously, we reported on the early effects of ionizing radiation on microvascular networks at 3, 7, and 30 days post-irradiation [1-3]. Data from the early time points suggested that ionizing radiation significantly alters the …
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Characterization of Glucocorticoid Receptor Promoter Methylation in Breast Cancer
… promoter whereas no methylation was detected in normal tissue. RT-PCR and 5’ RACE analysis identified exon 1B as the predominant alternative first exon in the breast. Tumours methylated near exon 1B had decreased GR expression compared to unmethylated samples, suggesting that this region is …
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Tetracycline-7-boronic acid
… fact that the tetracyclines are not retained by normal tissue should remove the danger of destruction of this tissue.
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Prevalence and fate of pro-oncogenic clones in the human colon
Normal aged tissues are thought to exist as a patchwork of mutations. The detection of cancer-driver mutations in the normal human colonic epithelium had been so far limited. Using immunohistochemistry and sequencing methods, and by screening a large number of patients and crypts, pro-oncogenic …
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The regulation of type I collagen gene expression in stromal fibroblast by breast tumour cells
… are decreased in stage II and III breast tumour tissue compared to adjacent normal tissue.
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Mathematical Models of Chemotherapy
… effects of chemotherapy on both cancerous and normal tissue. Each model is defined by either a single homogeneous equation or a system of heterogeneous equations which describe the states of the normal and/or cancer cells. Periodic terms are added to model the effects of the chemotherapy. What …
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Accurate Identification of Significant Aberrations in Cancer Genome: Implementation and Applications
… scale with high resolution. However, due to normal tissue contamination, the observed intensity signals are actually the mixture of copy number signals contributed from both tumor and normal cells. This genetic confounding factor would significantly affect the subsequent copy number analyses. …
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A Comparison of Two 'In Vitro' Assays to Assess Radiosensitivity in Patients Receiving Radiotherapy
This thesis addresses the occurrence of normal tissue damage as a limiting factor in curative radiotherapy and the need for predictive radiosensitivity testing. Patients who display unusual sensitivity to radiation may also exhibit a poor DNA repair capacity. Consequently, in vitro assays which …
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Analysis of 3D and 4D proton treatment planning for hepatic tumors
… dosimetric gain of gating on radiation dose to normal tissue. 4DCT scans are collected for 25 patients with hepatic tumors treated by proton radiotherapy. The 4D treatment planning process explicitly takes into account respiratory motion of abdominal organs. A 4DCT scan consists of 10 3D …
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Altered protein expression patterns in oesophageal cancer
… at different levels in oesophageal tumour tissue when compared to normal tissue. The identification of such proteins would be an important step towards the development of better diagnostic and therapeutic strategies for this disease. Two proteomic approaches, were employed to identify …
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Automated to ols for Contour Review in Radiotherapy
… to tumor control); in one in ten cases, it is normal tissue sparing (related to treatment toxicity). Essentially all North American institutions with accredited residency training programs hold peer review to some capacity. However, accessibility to practicing routine peer review (especially of …
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