Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Normal chow"”.
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The role of Arginyltransferase 1 in body weight homeostasis
… and ATE1-knockout (ATE1-KO) mice maintained on a normal chow diet, or a high fat diet. We found that on both diets, ATE1-KO mice weighed significantly less than WT mice despite consuming more food (hyperphagia). We also found that, similar to WT mice on normal chow, ATE1-KO mice remain responsive …
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Effect of High Fat Diets Containing No Cholesterol on the Properties of Rabbit Serum Lipoproteins and the Catabolism of Very Low Density Lipoproteins
… white rabbits were successively maintained on normal chow, a semisynthetic diet high in safflower oil (SAFF diet), and a semisynthetic diet high in hydrogenated coconut oil (COCO diet) for 9 weeks each.
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The Role of Adipose-Specific Free Fatty Acid Receptor 2 in Obesity and Associated Metabolic Dysfunction
… and assessed metabolic outcomes under normal chow and high-fat, high-sugar Western diet conditions, both with and without dietary fiber supplementation. We found that adiposespecific FFA2 deletion had minimal metabolic consequences under standard dietary conditions but significantly …
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Modulation of Innate Immune Cell Signaling Pathways by Staphylococcus aureus and Omnigen-AF®
… MyD88 KO, and TLR4 KO mice were fed either normal chow or supplemented with OmniGen-AF® for two weeks. Mice were immunosuppressed with dexamethasone and challenged with LTA. LTA overcame immunosuppression in a TLR4-depenent manner regardless of supplementation with OmniGen-AF®. Overall this …
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The Effect of Leucine Supplementation on Biomarkers of Mitochondrial Biogenesis and Protein Synthesis in Soleus Muscle of Rats Fed a High-Fat Diet
… (p < 0.05) in response to a HFD compared to normal chow. However, TUFM gene expression declined (p < 0.05) in response to a HFD with or without leucine. CONCLUSION: Leucine supplementation did not stimulate an increase in TFAM, mtIF2, and TUFM when exposed to a HFD, but does however stimulate …
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The roles of diet and SirT3 levels in mediating signaling network changes in insulin resistance
… system, I analyzed liver tissue from mice fed a normal diet (insulin sensitive) or mice fed a high fat diet, thus inducing insulin resistance. Quantification of phenotypic and network events in response to insulin and utilization of computational techniques revealed activated pathways and nodes …
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Impacts of dietary obesity on muscle stem cell behaviors
… of obesity on SC behaviors, we fed C57BL/6 mice normal chow (NC, control) or high-fat diet (HFD) for 10 wks and performed SC proliferation and differentiation assays in vitro. SCs from HFD mice formed colonies with smaller numbers (P < 0.001) compared to those isolated from NC mice, and this …
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Chronic Circadian Misalignment Disrupts the Circadian Clock and Promotes Metabolic Syndrome
… the12/12-hour light/dark cycle. Mice were fed a normal chow diet (10% fat) or a high fat diet (60% fat). Animals were sacrificed and samples were collected at 4-hour intervals on day 2 of the weekend. Exposure to chronic circadian misalignment by light disruption or high fat diet altered …
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Modelling altered Glucocorticoid Sensitivity: From HPA axis to metabolic abnormalities in mice and humans
… GR gene promoter. GR-/- mice are present in a normal Mendelian ratio before birth. Intriguingly, 1 (of 36/146 expected if null allele not lethal) survived to adulthood suggesting this might be a hypomorphic rather than a null allele. Heterozygous 15 (GR+/-) mice showed 40-45% reductions in GR …
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Role of 11β-hydroxysteroid dehydrogenase type 2 in protection against inflammation during atherogenesis: studies in the Apoe-/- /11β-HSD2-/- double knockout mouse.
… conferring aldosterone specificity upon the normally unselective MR. Recent evidence suggests that 11β-HSD2 may also afford protection of MR in the cells of the vasculature, providing possible mechanisms by which MR activation may directly promote atherosclerosis. Consistent with this, …
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Identification of a conserved alternative mRNA splicing program that supports hepatic growth and maturation during development and regeneration
… putative regulators, RNA Binding proteins, in normal liver maturation and regeneration. In the second chapter of the thesis, I studied the changes occurring in the liver transcriptome during postnatal periods of development. To characterize the conserved AS program during mammalian liver …