Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 239 for “"Normal cells"”.
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Specific, Reversible Cytostatic Protection of Normal Cells Against Negative Effects of Chemotherapy
… cancer chemotherapeutics target proliferating cells and tissues, all dividing cells, whether normal or tumor, are affected. Cell culture studies have demonstrated that UCN-01 is able to reversibly and selectively arrest normal dividing cells; tumor cells lines do not undergo this temporary …
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Car-Modified T Cells Capable of Distinguishing Normal Cells From Malignant Cells
<p>T cells can be redirected to target tumor-associated antigen (TAA) by genetic modification to express a chimeric antigen receptor (CAR), which fuses the specificity derived from an antibody to T-cell activation domains to result in lysis of TAA-expressing cells. Due to the potential for …
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ΟΙ ΣΥΝΕΠΕΙΕΣ ΤΗΣ ΕΚΦΡΑΣΗΣ ΤΗΣ ΠΡΩΤΕΙΝΗΣ Ρ21 ΓΟΝΙΔΙΑΚΟΥ ΠΡΟΙΟΝΤΟΣ ΤΟΥ ΟΓΚΟΓΟΝΙΔΙΟΥ Η-RAS1 ΚΑΤΑ ΤΗΝ ΚΑΡΚΙΝΟΓΕΝΕΣΗ
… ALSO WERE INVESTIGATED MIXED CULTURES OF NORMAL EARLY PASSAGE BALB/C EMBRYO CELLS AND BALB/C 3T3 CELLS TRANSFORMED BY THE HUMAN T24 H-RAS ONCOGENE. THE PRESENCE OF AN EXCESS OF NORMAL CELLS COULD SUPPRESS THE PHENOTYPE OF TRANSFORMED CELLS IN VITRO. A SIMILAR TYPE OF SUPPRESSION BY NORMAL …
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Some aspects of the ultrastructure and enzyme cytochemistry of normal and virus-transformed cells
… investigations have been applied to three normal and transformed cell systems in order to relate changes in hydrolytic enzyme activity to changes in ultrastructural organisation occurring when normal cells in vitro are transformed by tumour virus. On transformation changes in cell shape, …
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유전자 적중법을 이용한 조건적 LDHB 유전자 삭제 마우스 제작
In general, differentiated cells produce most of the ATP to growth from glucose through metabolism. Normal cells produce 2 ATP by glycolysis in the cytoplasm and convert to 2 pyruvates. Next, this pyruvate produces about 36 ATP by oxidative phosphorylation in the mitochondria. On the other hand, …
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DNA synthesis and methylation in normal and transformed cells
… known to affect DNA synthesis in tissue cultured cells, were tested for their ability to alter the methylation status of DNA. The effects of three DNA synthesis inhibitors, viz. hydroxyurea (HU), 1-S-D-arabinofuranosyl cytosine (ara-C) and aphidicolin were examined on a normal embryonic lung …
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Investigating the by-stander effect of Hypericin induced photodynamic therapy on human skin cells
… efficient and selective targeting of the tumoral cells with minimal collateral damage to the surrounding normal cells, as it is well know that cancer therapies have bystander effects on normal cells in the body, often causing undesirable side effects. PDT can induce a bystander effect, defined as …
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Molecular cell cycle mechanisms of human prostate crcinoma insensitivity to TGF-β?
TGF-β is a potent growth inhibitor of epithelial cells. However, many transformed cells have lost their sensitivity to this growth inhibitory effect. The molecular mechanism of such insensitivity is not yet understood. Here, we have studied the TGF-β1 effect on normal human prostate and carcinoma …
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MOLECULAR DEFECTS OF MEF2 FAMILY PROTEINS AND NAC PROTEINS THAT BLOCK MYOGENESIS AND PROMOTE TUMORIGENESIS IN RHABDOMYOSARCOMA
… form of soft tissue tumors in children. RMS cells have many features of skeletal muscle cells, yet do not differentiate. Thus, our studies have focused on the molecular defects present in these cells that block myogenesis. We have found MEF2D is absent in RMS cell lines representing both …
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Normal cell signals in human cancer transcriptomes
Cancer cells arise from normal cells, and may retain transcriptional patterns present in the cell of origin. Recent advances in single-cell transcriptomics have allowed us to profile both normal and cancer cells at a single cell resolution, enabling direct comparisons between the two. Such …
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Ionic Liquids and GUMBOS for Biomedical and Sensing Applications
… The toxicity of chemotherapeutic agents to normal tissues and drug resistance are a major concern in cancer treatment. In this dissertation, GUMBOS and nanoGUMBOS as well as ionic liquids and nanodroplets are explored as possible chemotherapeutic agents with minimal toxicity to normal cells. …
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Peptide Targeting of Platinum Anti-Cancer Drug and Synthesis of Water Soluble Monofunctional Pt(II) Complexes Useful for Biological Labeling
… selective delivery and destruction of cancer cells that had CD13 receptors compared to untargeted carboplatin drug. The development of targeted chemotherapeutic has opened a new approach for efficient delivery of antitumor toxins with minimal exposure to normal cells. Several peptide sequences …
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Radiation effects on the blood-brain barrier
… It is a novel approach to expose the endothelial cells to much higher levels of ionizing radiation relative to normal cells by utilizing the boron neutron capture reaction. When boron-containing compounds are restricted to the lumen of the blood vessel, the resulting high-LET alpha and lithium …
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Characterization of Cytotoxicity against Cancer Cells induced by Human Monoclonal Antibody Specific to TRAIL-R1
… induces apoptosis in a variety of tumor cells through activation of TRAIL-R1 (DR4) and TRAIL- R2 (DR5) with no effect on most normal cells. Also, Tumor cells that are resistant to TRAIL can be sensitized by combination treatment with chemotherapheutic agent or irradiation. But it has also …
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Using <i>Drosophila melanogaster</i> as a Whole-Model Animal System to Elucidate the Mechanism of Action of Novel Anticancer Agents
… and poor selectivity between cancerous and normal cells. This lack of specificity leads to side effects. Our lab used a prodrug strategy to design a set of novel chemotherapeutic agents. The drugs utilize a hallmark of many cancer cells, oxidative stress, for activation. This allows them to …
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HOW MICROVESICLES ARE "BUDDING" INTO THE CANCER CONVERSATION: THE ROLE OF GLYCOCALYX-INDUCED MEMBRANE BENDING
… as local paracrine signaling between cancer and normal cells. However, tumor-derived extracellular vesicles (EVs), which are lipid bilayer vesicles released from cancer cells, can travel long distances in the body and cytosolically deliver oncogenic cargos, such as DNA, RNA, and proteins, to …
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Somatic evolution in human blood and colon
All cancers were once normal cells. They became cancerous through the chance acquisition of particular somatic mutations that gave them a selective advantage over their neighbours. Thus, the mutations that initiate cancer occur in normal cells, and the normal clonal dynamics of the tissue determine …
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Investigating the role of the Renin Angiotensin System in cancer
… in cervical cancer cell lines compared to normal cells and that this correlated with elevated ACE-1 enzyme activity in cancer cells. Treatment with the ACE-1 inhibitors, Captopril and Lisinopril, reduced this activity. We showed that ACE-1 axis stimulation in cancer cells results in …
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The effects of sperm dose, semen quality, and retrograde sperm blockage on accessory sperm number and embryo quality in the artificially inseminated bovine
… 4. Compare the percentage of morphologically normal accessory sperm with the percentage of normal cells in the inseminate. Using excised reproductive tracts, a French insemination rod housed in a 24-gauge Foley catheter was determined to be effective in blocking retrograde flow of semen …
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In Vitro Long Term Time-Lapse Imaging Studies Of The Mcf-10 Mammary Cancer Cell Progression Model Using A Custom Incubator Microscope
Time-lapse imaging of cells has been historically limited to a few hours because of the difficulty associated with maintaining the appropriate physiological pH and temperature of the cells during prolonged imaging. Carbon dioxide produced by cellular respiration changes the pH of the medium, and …
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