Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Norepinephrine transporter"”.
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Dopamine-Beta-Hydroxylase and Norepinephrine Transporter Immunoreactivity in Rat Taste Buds
… of neurotransmitters modulating taste response, norepinephrine (NE) may be the least understood. Although the physiological role of NE has been tested, it is still unclear whether the rat taste bud may serve as an endogenous source of neurotransmitter or if it must be taken up from outside the …
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Computational Ligand-Based CNS Therapeutic Design: The Search for Novel-Scaffold Norepinephrine Transporter Inhibitors
Monoamine transporter (MAT) proteins are responsible for regulating cellular signal transduction through control of neurotransmitter reuptake in the synapse, and are therefore relevant to diseases including addiction, psychosis, anxiety and depression. MATs, specifically the serotonin transporter …
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Design and evaluation of novel PET and SPECT tracers for imaging the monoamine system and the P-gp transporter
… being the monoamine system and the P-gp transporter, were developed and evaluated in vivo. The first objective of this thesis was the design of radiotracers for the monoamine system more specifically, the norepinephrine transporter, monoamine oxidase and dopamine transporter which are all …
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Synthesis and SAR study of Meperidine Analogues as Selective Serotonin Reuptake Inhibitors (SSRIs)
… to have potent binding affinity for serotonin transporters (SERT) (Ki = 41 nM) and be an inhibitor of serotonin reuptake. Based upon these pharmacological results meperidine has been identified as a lead compound for the development of a novel class of serotonin-selective reuptake inhibitors …
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DYNAMIC BEHAVIOR AND LINEAGE PLASTICITY OF THE PULMONARY VENOUS ENDOTHELIUM
… single cell transcriptomics, we identified the norepinephrine transporter Slc6a2 as a marker of pulmonary venous endothelial cells and targeted that locus to generate a venous-specific, inducible Cre mouse line. Contributions of the venous endothelial cells to angiogenesis were examined during …
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Towards Precision Medicine: Characterizing and Predicting Antidepressant Remission Heterogeneity in Late-life Depression Using Genetic Data
… approach, we show an association of the norepinephrine transporter gene (SLC6A2) with LLD remission (OR = 1.67 [1.13, 2.42], p = 0.009), which is a validated target of venlafaxine. In addition, we identify variants in novel genes of interest, particularly in the PIEZO-type …
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Effect of antidepressants and adolescent stress on catecholamine transmission in the rat bed nucleus of stria terminalis (BNST): a microdialysis study
… that the administration of selective blockers of norepinephrine transporter (NET) increases the extracellular concentration (output) of dopamine, suggesting that dopamine could be captured by NET in the BNST. Among new experimental strategies investigated for the theraphy of depression, the …
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I. Advanced Fluorescent False Neurotransmitters for the Study of Monoamine Transporter Activity and Synaptic Transmission
… for use in the study of monoamine transporter activity and distribution, as well as synaptic transmission in the brain. The second section details early studies concerning experimental therapeutics recently identified by our group to induce the synthesis and release of Glial Derived …
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Monoamine Transporter Photoaffinity Ligands Based On Methylphenidate and Citalopram: Rational Design, Chemical Synthesis, and Biochemical Application
Monoamine transporters (MATs) are a family of proteins that include the dopamine transporter (DAT), serotonin transporter (SERT), and norepinephrine transporter (NET). Specifically, dysregulation of MAT function is associated with a host of disease states including drug abuse, major depressive …
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Developmental Monoamine Signaling Impacts Adult Affective and Aggressive Behaviors
… consequences of developmental serotonin (5-HT) transporter (5-HTT) and monoamine oxidase A (MAOA) blockade. Pharmacologic MAOA or 5-HTT blockade in adulthood has antidepressant and anxiolytic efficacy. Yet, genetically conferred MAOA or 5-HTT hypo-activity is associated with altered aggression …