Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Nonviral Gene Delivery"”.
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Application of endostatin using nonviral gene delivery toward the regeneration of articular cartilage
… limited capacity for spontaneous healing. Angiogenesis may interfere with maturation of naturally avascular tissues. Our rationale is that the use of endostatin, a potent angiogenesis inhibitor, will facilitate the formation of hyaline cartilage during regeneration. The objective of this thesis …
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Gene-supplemented collagen-glycosaminoglycan scaffolds for nonviral gene delivery in articular cartilage tissue engineering
… (CG) scaffolds for the nonviral delivery of the gene encoding for insulin-like growth factor (IGF)-I, as a novel means to provide a local, elevated, and prolonged release of a therapeutic growth factor via transfection of cells seeded or migrating within the scaffold. In …
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Synthesis, characterization, and evaluation of photo-active amphiphiles for gene delivery applications
Gene therapy has the potential to alter the landscape of medical therapeutic techniques by offering a means of introducing or knocking out genes to treat a number of diseases. Both viral and nonviral vectors are currently being utilized in gene therapy clinical trials. To overcome the obstacles in …
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Calcium Phosphate Nanoparticle Synthesis and Manufacture using Microwave Processing for Biomedical Applications
… been shown to be effective scaffolds for bone regeneration and as gene delivery carriers. However, significant problems related to their synthesis have limited their clinical use.</p><p>Conventional processing produces CaP with low crystallinity and large particulates which contributes to the …
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Imidazole-Containing Polymerized Ionic Liquids for Emerging Applications: From Gene Delivery to Thermoplastic Elastomers
… of charge density and hydrogen bonding on nonviral DNA delivery. Copolymers with higher charge densities exhibited increased cytotoxicity, whereas increased hydroxyl concentrations remained nontoxic. DNA binding affinity increased with increased charge densities and increased hydroxyl …
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Tailoring Structure and Function of Imidazole-Containing Block Copolymers for Emerging Applications from Gene Delivery to Electromechanical Devices
… for a variety of applications including gene delivery vectors, ionic liquids, electromechanical actuators, and novel monomers and polymers. The imidazole ring provides a unique building block for these applications due to its thermal stability, aromatic nature, ability to form ionic …