Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Nonsteroidal anti‑inflammatory drugs (NSAIDs)"”.
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The renal effects of nonsteroidal anti-inflammatory drugs (NSAIDS) in dogs with chronic kidney disease (CKD)
… angiotensin II, and vasopressin. Nonsteroidal anti-inflammatory drugs (NSAIDs) produce both their beneficial and detrimental effects through inhibition of the cyclooxygenase enzyme and subsequent interference with prostaglandin production. Healthy canine kidneys express both COX-1 …
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The effects of topical diclofenac, flurbiprofen, and ketorolac on corneal sensitivity in normal cats
… to reduce ocular inflammation and nonsteroidal anti-inflammatory drugs (NSAIDs) to control clinical signs associated with ocular pain. Although topical NSAIDs are commonly used in the treatment of a variety of surface ocular diseases, studies demonstrating the effects of topically …
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Effects of chronic exposure to ibuprofen and naproxen on Florida flagfish (Jordanella floridae) over one complete life-cycle
Nonsteroidal anti-inflammatory drugs (NSAIDs) are a class of drugs prescribed to relieve pain, fever and inflammation, and are among the most commonly consumed medications in Ontario. Approximately 70% of the ingested dose is excreted unchanged or as an active metabolite, much of which reaches the …
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Concomitant Suppression Of Both Cox-1 And Cox-2 Is Not Sufficient To Cause Gastroenteropathy Associated With Chronic Nsaid Use
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most widely used nonaddictive medications for the management of chronic pain and inflammation; however, these drugs are associated with many gastrointestinal and cardiovascular adverse events, including intestinal bleeding, ulceration, stenosis, …
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Establishing Decision Limits for Therapeutic Drugs Detected in Animals Exhibited at Livestock Shows
… to gain a competitive advantage, such as doping. Antidoping regulation in the livestock show industry often involves drug testing. Detection of therapeutic drugs at very low concentrations in approved animal species raises questions about current anti-doping regulations in exhibition animals. …
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The Prostaglandin E2 Receptor Subtype 3E and its involvement in tauopathies
… in the onset of Alzheimer’s in subjects using nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs inhibit enzymes in the cyclooxygenase-2 (COX-2) pathway which play a key role in synthesising prostaglandin E2 (PGE2) from arachidonic acid. PGE2 has been implicated in preclinical stages of …
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The Pharmacokinetics of Firocoxib after Multiple Oral Doses to Neonatal Foals
… Foals are more sensitive to the side effects of nonsteroidal anti-inflammatory drugs, (NSAIDs), particularly due to immature renal clearance mechanisms and ulcerogenic effects on gastric mucosa. Firocoxib, a novel second generation NSAID, is reported to have reduced side effects due to its COX-2 …
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Aqueous humor concentration and prostaglandin E2 suppression efficacy of topically applied ophthalmic ketorolac 0.5% and diclofenac 0.1% solutions in dogs with cataract
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for their analgesic, anti-pyretic and anti-inflammatory properties in both human and veterinary patients. Topical ophthalmic NSAIDs are commonly employed in the management of intraocular inflammation (uveitis), …
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Heme Oxygenase-2 as a novel target to treat inflammation and chronic neuropathic pain associated with corneal injury and surgery
… removal (first step of refractive surgery) an inflammatory response arises and corneal subbasal nerve density does not recover for up to five years. Furthermore, the number of stromal nerves decreases by nearly 90% after LASIK leading to possible complications. One of the most notable adverse …
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Monitoring medication problems in the elderly and strategies for their reduction.
… Of all 57 medication-related admissions, nonsteroidal anti-inflammatory drugs (NSAIDs) were responsible in a quarter (24.5%, 14/57). The incidence of MRPs estimated against frequency of prescribing of each medication group was also highest with NSAIDs (17.6%, 18/102). Among groups of …
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Epigallocatechin-3-gallate and tolfenamic acid induces apoptosis and growth inhibition in head and neck cancer : Involvement of NSAID activated gene-1
… importance to investigate the efficacy of anti-oxidant and nonsteroidal anti-inflammatory drugs (NSAIDs) as chemopreventive agents. At present, the chemopreventive agents that have been most widely investigated as chemopreventive agents are NSAIDs and …
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Regulation of Cataractogenesis in Culture Bovine Lenses by 5-Phenyldithiole-3-Thione-NSAID Hybrid Molecules
… production of hydrogen sulfide (H2S) and Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen can mitigate cataractogenesis. Therefore, this study investigated the pharmacological actions and mechanisms by which ATB 343 (indomethacin & H2S donor) and ATB 337 (diclofenac & H2S …
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Nonsteroidal anti-inflammatory drugs and prostaglandin synthesis inhibitors in the treatment of urinary diseases and their effects on renal functions: clinical studies
… pressure, lower urethral pressure and inhibit antidiuretic hormone. We hypothesized that high production of prostaglandins or their dominant action on the urinary system may play a role in the pathogenesis of primary enuresis and nocturnal frequency of micturition. To test this, inhibition of …