Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Nonribosomal peptide synthetase"”.
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A Nonribosomal Peptide Pheromone Controls Male-Induced Female Sexual Development in Schistosoma mansoni
… a master transcription regulator (GLI1), a nonribosomal peptide synthetase (SmNRPS) and a pheromone metabolite β-alanyl-tryptamine (BATT) were discovered to firstly demonstrate the way a male parasite might signal his paired female. Using RNA sequencing, biochemistry assays and metabolomic …
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Reengineering and Discovery of Nonribosomal Peptide Synthetases
Nonribosomal peptides are an important class of natural products including the life-saving antibiotics penicillin and vancomycin and the deadly microcystins and cereulide. This important category of natural products is thus a focus of many research labs around the world, including the Kelleher lab. …
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Comparative and Functional Genomic Analysis of <i>Streptococcus Equi</i> and <i>Streptococcus Zooepidemicus</i> : Identifying Novel Vaccine Targets
… element carrying a novel siderophore-like nonribosomal peptide synthetase (NRPS) system. The NRPS shares similarity with the yersiniabactin system found in the high pathogenicity island of <i>Yersinia pestis</i> and is the first of its kind to be identified in streptococci. As this genetic …
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A genomics-led approach to deciphering heterocyclic natural product biosynthesis
… trienes produced by a polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) pathway in Streptomyces sp. KO-7888 and Streptomyces sp. OM-5714. The phthoxazolin pathway was used as a model to study 5-oxazole and primary amide formation in PKS-NRPS pathways. An unusually large gene …
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Catalytic C-H oxidation reactions for the synthesis and diversification of hydroxyamino acid motifs
… cyclization on a leucine-β-allylglycine dipeptide substrate to install a vinyl oxazolidinone moiety. Mechanistic investigations into the role of the dibutylphosphate co-catalyst revealed that it may play multiple roles beyond promoting formation of a cationic π-allylPd intermediate, …
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Investigation of the biosynthesis of the phosphonate antibiotics bialaphos and dehydrophos
… attached to two alanine residues. The peptide bond formation and methylation on phosphorus in PTT are key steps in PTT biosynthesis, however, the exact timing of these transformations was not known. To provide insights into these questions, a heterologous expression system was developed …
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Functional Analysis of Secondary Metabolite Biosynthesis-Related Genes in Alternaria brassicicola
… contribute to pathogenicity, we identified seven nonribosomal peptide synthetases (NPSs) and 10 polyketide synthases (PKSs) in the A. brassicicola genome. The phenotype resulting from knockout mutations of each PKS and NPS gene was investigated with an emphasis on discovery of fungal virulence …