Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Nonmuscle"”.
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Actomyosin Contractility in Nonmuscle Cells
<p>Forces and stresses generated by the action of myosin minifilaments are analyzed via simulation of their motion in idealized computer-generated random, isotropic actin networks and actin bundles. The networks and bundles are generated as random collections of actin filaments in two dimensions …
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A role for myosin in the regulation of mammalian nonmuscle cell motility.
A role for myosin in the regulation of mammalian nonmuscle cell motility.
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Distinct Functions and Regulation of Nonmuscle Myosin II Isoforms a and B in Cell Motility
… migration machinery, the molecular motor protein nonmuscle myosin II (myosin II) has long been a subject of scientific inquiry. It is now generally accepted that the contractile forces generated by myosin II contribute directly or indirectly to every step in migration. Interestingly, three …
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Molecular organization of the actin cortex in apical constriction and epithelial folding
… well known in muscle, it is less understood in nonmuscle epithelia, which change shape during development and form functional barriers on an organism's inner surfaces. Prevailing models for nonmuscle contractility suggest that the intrinsic ability of mixed polarity actin networks and uniformly …
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Cardiac Calsequestrin Phosphorylation And Trafficking In The Mammalian Cardiomyocyte
… of CSQ2 phosphorylation using cardiomyocyte and nonmuscle cell CSQ2 kinase sources was successfully carried out with three specific inhibitors of CK2: TBB, DMAT and TBCA. TBCA produced identical inhibition curves for both cellular kinase sources and commercial CK2α′ kinase, with increasing …
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The Cytoskeletal Mechanisms of Cell-Cell Junction formation in Endothelial Cells
… direction. Subsequently, bridge bundles recruit nonmuscle myosin II and mature into stress fibers. Myosin II activity was important for bridge formation and accumulation of VE-cadherin in nascent adherens junctions. Our data reveal a mechanism of cell-cell junction formation in endothelial cells …
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Engineered Cytoskeletal Arrays Reveal Mechanisms Of Membrane Transport And Tubulation
… intersections is inhibited by the presence of nonmuscle tropomyosin Tm2 at the actin intersection. This suggests that tropomyosin may regulate Myo1c tethering of kinesin-1-driven cargo within cells by preventing termination of motility until reaching the highly dynamic actin just beneath the …
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Purification and characterization of Clostridium perfringens iota toxin
… in vitro. Recent evidence suggests that nonmuscle actin, involved in the cytoskeletal structure of eucaryotic cells, may act as the in situ acceptor.
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Mechanisms of Actomyosin Contractility in Cells
… mechanisms of actomyosin structures in nonmuscle cells are relatively obscure. Here we elucidate the contraction mechanisms of two prominent and related actomyosin structures: the contractile ring, which constricts to divide the cell during cytokinesis, and the stress fiber, which is …
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Genetic Approaches to Study Tissue Morphogenesis in Drosophila
… in the model organism Drosophila melanogaster. Nonmuscle myosin II (myosin hereafter) has well-established roles in generating contractile force on actin filaments during morphogenetic processes. Myosin activation is regulated by phosphorylation of the myosin regulatory light chain (MRCL, …
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Cytotoxic T lymphocyte biology under the microscope
… namely the Arp2/3 complex, formins, and nonmuscle myosin IIa, is determined. Finally, I turn to forces at the cytotoxic immune synapse by creating artificial synapses on traction force gels. This reveals dynamic changes in actin conformation here, which correlate once again with force …