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Showing 1 to 14 of 14 for “"Nonheme"”.
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Mono- and Dinuclear Nonheme Iron Model Complexes: O-O Bond Activation, Structural Characterization and Reactivity Study
… and reactivities of mono- and dinuclear nonheme iron model complexes were investigated. In Chapters 2 and 3, O-O bond activation of H2O2 by the dinuclear complexes [(FeIII2(μ-O)(μ-OH)L2]3+ (1A) and [(FeIII2(μ-OH)2L2]4+ (2A), L = tris(3,5-di-methyl-4-methoxypyridyl-2-methyl)amine, to form …
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Characterizing a structural and functional model of nitric oxide reductase performing NO and O2 reduction in engineered myoglobin
… the role of structural features, such as nonheme metal ion, in conferring biologically significant activities such as NO and O2 reduction. A detailed understanding of the role that nonheme Fe plays in NOR reactivity in FeBMb was previously unexplored, but replacement of Fe-PPIX with …
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Understanding structure-function relations in heme-copper oxidase using myoglobin-based enzyme models
… reductase (NOR), that in turn, utilize a heme-nonheme diiron center to catalyze the two electron reduction of nitric oxide to nitrous oxide during biological denitrification processes. The homology between these two classes of enzymes is not just structural but also functional: the NORs can …
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The effect of two reheating methods and storage on the development of warmed-over flavor in precooked chicken parts
… storage did not have a significant effect on the nonheme iron content of breasts or legs. The effects of heating temperature were inconsistent for the legs and breasts which was attributed to the different initial iron content of the legs, and the release of nonheme iron during the initial …
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Structural and functional investigations of mechanisms of iron-utilizing enzymes
… of isonitrile formation by an mononuclear nonheme iron(II) α-ketoglutarate dependent dioxygenase, ScoE. The first part of this thesis focuses on mononuclear nonheme iron(II) α-ketoglutarate dependent dioxygenases: enzymes which use molecular oxygen, α-ketoglutarate and a mononuclear Fe(II) …
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Function and Mechanism of Alkbh5 In N6-Methyl-Adenosine Rna Modification In Glioblastoma
… is erased by two members of the AlkB family of nonheme Fe(II)/a-ketoglutarate (a-KG)-dependent dioxygenases, fat-mass and obesity associated protein (FTO) or ALKBH5. ALKBH5 affects nuclear RNA export and metabolism, gene expression and mouse fertility. To date, little is known about the …
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Computational study on the selectivity of iron-containing hydroxylase
… catalyzed by Iron-containing heme and nonheme were studied, using cytochrome P450 and PtlH as examples. In this work, the C-H activation in the hydroxylation reaction of a model substrate artemisinin catalyzed by three selective P450BM3 variants was studied by combined molecular …
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Predicting learning success from patterns of pre-training magnetic resonance images
… (ASL). We then discovered that (patterns of) nonheme iron (not heme) is the underlying factor driving learning prediction. This discovery of the relationship between iron concentrations and learning ability in healthy young adults could not only guide the development of potential neuromarkers …
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Mechanisms of Enzyme Neofunctionalization in Plant Specialized Metabolism
… metabolism by examining two enzyme families: nonheme iron(II)- and 2-oxoglutarate-dependent halogenase and BAHD acyltransferase. First, we describe the genomic- and biochemical-basis for gene duplication and neofunctionalization of flavonol synthase (FLS) that led to the unique emergence of …
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Investigating the invasive and cytoprotective properties of the heme binding protein HRG-1 in cancer cells
… required for trafficking of both heme-bound and nonheme-bound receptors and suppression of HRG-1 results in perturbed receptor trafficking to the lysosome. Suppression of HRG-1 in HeLa cells increases toxic heme accumulation, reactive oxygen species accumulation, and DNA damage resulting in …
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Investigations of metalloenzymes involved in bacterial natural product biosynthesis
… C-terminal cysteine residue by the complex of nonheme iron oxygenase TglH and putative substrate recognition protein TglI, was previously identified as a step in the biosynthetic pathway of the sulfur-substituted glutamate analog 3-thiaglutamate in a strain of Pseudomonas syringae. Chapter 4 …
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Understanding orchestrated chemical reactions in toluene/o-xylene monooxygenase from pseudomonas sporium OX1
… Functional Versatility of Carboxylate-Bridged Nonheme- Diiron Motifs: sMMO and ToMO. Several metalloenzymes utilize a carboxylate-bridged non-heme diiron motif for dioxygen activation. Despite their conserved diiron active site structures and mechanisms of dioxygen activation, they catalyze a …
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Coordination Geometries in Metallobundles Enforcing Oxidative and Hydrolytic Catalysis and Designing Biomaterials for Use As Antimicrobials
… observed the coordination ligands are similar to nonheme catalases. Therefore, we sought to identify metal preference of this four-helix bundle and establish possible mechanisms utilized by Mtb to disproportionate toxic oxygen metabolites. Conversely, a possible defense strategy by humans to …
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Bio-inspired iron complexes featuring secondary coordination sphere interactions: Ligand design strategies and dioxygen reactivity
The activation of dioxygen plays an important role in processes ranging from biological oxidation to energy storage and utilization. In Nature, metalloenzymes use complex architectures to promote these multi-electron and multi-proton reactions using first-row transition metal centers. Many enzymes …