Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Nondisjunction"”.
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Chromosome malorientation precedes nondisjunction during female meiosis I
… poles to ensure proper segregation, otherwise nondisjunction can occur which would form aneuploid gametes. The recent discovery that chromosomes do in fact congress prior to metaphase I arrest in <em>Drosophila </em>requires a reexamination of the mechanisms behind nondisjunction. To do this, a …
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The physiological role of the two isoforms of DNA topoisomerase II in human cells
… low affinity. Consequently an increased rate of nondisjunction is observed in these cells. It is concluded that high affinity chromatin binding of topoisomerase IIalpha is essential for chromosome condensation/disjunction and that topoisomerase IIbeta does not adopt these functions. A centrosomal …
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A role for the histone variant HTZ1 in meiotic chromosome segregation
… strains also showed an increase in chromosome nondisjunction during both meiosis I and II and premature sister chromatid separation during meiosis I. These results suggest a novel role for H2AZ in regulating meiotic chromosome segregation and possibly in centromeric protection and kinetochocore …