Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"Noncoding rna"”.
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The Regulation and Evolution of long, noncoding RNA Transcription
… leading to the production of thousands of long, noncoding RNAs (lncRNAs, > 200 basepairs), which are distinct from more traditional noncoding RNAs such as transfer RNAs or ribosomal RNAs. This striking finding is observed across all eukaryotes, from humans to budding yeast. It was once thought …
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Small RNAs Regulate Transcription by Interacting with Noncoding RNA Transcripts
… the Corey lab has demonstrated that short RNA duplexes designed to target the promoter region for human genes can inhibit or activate gene expression in a sequence dependent manner. The mechanism by which RNAs achieve promoter recognition has remained unclear. Sequence specific recognition …
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Regulation of Pumilio RNA Binding Proteins by Long Noncoding RNA NORAD
… transcribed and encodes thousands of long noncoding RNAs (lncRNAs). Defining the mechanism of action of lncRNAs has been a critical challenge and priority for understanding their biological functions. An important example of this is the lncRNA NORAD, which is a highly conserved lncRNA that …
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The novel long noncoding RNA lncUSMycN in N-Myc-induced oncogenesis
… study, I experimentally validated the novel long noncoding RNA up-stream of MYCN (lncUSMycN), which was originally annotated by bioinformatics analyses, within the 130 kb amplicon. Using rapid amplification of cDNA ends PCR, 140 extra nucleotides at the 5’-end of lncUSMycN were identified. Gene …
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Functional Analysis of Risk Single Nucleotide Polymorphism and Long Noncoding RNA in Prostate Cancer
… to dysregulate two gene isoforms of a long noncoding RNA (lncRNA) PCAT19. Furthermore, I validated the oncogenic properties of the lncRNA PCAT19, and revealed its function in prostate cancer progression through the upregulation of a subset of cell cycle genes with the RNA binding protein …
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Systematic Identification of Independent Functional Non-coding RNA Genes in Oxytricha trifallax
Functional noncoding RNAs participate in a variety of biological processes: for example, modulating translation, catalyzing biochemical reactions, sensing environments etc. Independent of conventional approaches such as transcriptomics and computational comparative analysis, we took advantage of …
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Characterization of Non-Coding RNAs in Regulating Thymic Epithelial Cell Responses to Pathophysiological Stress
… cells initiate the involutionary response. MicroRNAs (miRs) are small non-coding RNAs ~18-22 nucleotides in length that maintain cellular homeostasis and regulate stress responses. Previous work in the laboratory identified several microRNAs involved in regulating thymocyte responses to stress. …
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MEF2-regulated Gtl2-Dio3 noncoding RNAs in cardiac muscle and disease
… through direct regulation of the Gtl2-Dio3 microRNA mega-cluster. In addition to their expression in skeletal muscle, temporal expression analysis of selected Gtl2-Dio3 microRNAs revealed high enrichment in cardiac muscle. Therefore, I investigated the role of selected microRNAs from the …
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High intensity exercise induced regulation of the microRNA biogenesis pathway
… reticulum. Recent studies suggest that microRNAs (miRNA) – small noncoding RNA molecules that fine-tune gene expression by silencing mRNAs through translational repression and/or transcript destabilization – dynamically respond to exercise and regulate the expression of genes involved in …
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Novel Algorithms for Structural Alignment of Non-coding RNAs
Non-coding RNAs are biologically important molecules, with a variety of catalytic and regulatory activities mediated by their secondary and tertiary structures. Base-pairing interactions, particularly at the secondary structure level, are an important tool for identifying and studying these …
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The Role of the Human Nuclear Poly(A) Binding Protein in RNA Decay
Control of nuclear RNA stability is an important determinant of gene expression, but the factors involved in nuclear RNA decay remain largely unknown in higher eukaryotes. Here, I describe our work showing that polyadenosine (poly(A)) tails can stimulate transcript decay in the nucleus of human …
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Metabolic Disorders Rewire Systemic and Tumor Immunity to Shape Anti-Tumor Responses in Cancer Patients
… <p>The first centers on how obesity-driven noncoding RNA dysregulation suppresses NK cell fitness and renders cellular immunotherapy ineffective. To identify circulating mediators of obesity-associated immune suppression, snoRNA expression was profiled in human serum across a range of BMI …
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Discovery and characterization of Cas13b, a differentially regulated RNA-targeting CRISPR system
RNA plays a significant role in human biology and disease, not only as messenger RNA encoding proteins but also as noncoding RNA regulating DNA, proteins, and other RNA species. Until recently, it has been challenging to target RNA in a simple, efficient manner. CRISPR-Cas (clustered regularly …
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The Transposon-Encoded Protein TnpB is an RNA-Guided Nuclease
Programmable RNA-guided systems, such as CRISPR-Cas adaptive immune systems, perform a wide variety of biological functions and have been harnessed for important therapeutic and diagnostic biotechnologies. One CRISPR effector protein, the Cas12 nuclease, is hypothesized to have its evolutionary …
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Identification of epigenetically dysregulated genes in tumours that metastasise to the brain
… identified 7 genes including non-coding RNA genes dysregulated in BBM. Taken together, these 10 genes identified are metastatic suppressor or promoter genes, which include novel regulatory elements noncoding RNA (ncRNAs) genes such as microRNAs, long intergenic non-coding RNAs (lincRNAs) …
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Characterisation of Androgen Receptor Signalling and Metabolism in Prostate Cancer
… the AR) and Hox Transcript Antisense Intergenic RNA (HOTAIR) (a long noncoding RNA) can interact with the AR and are found to be elevated in CRPC. To investigate their effect on AR activity, luciferase reporter assays were performed. Results demonstrated that both factors can repress AR activity. …
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MicroRNA Expression Signature of Retinal Pigmented Epithelial Cells Associated with the Phenotype of Age-Related Macular Degeneration
… (RPE) and then the photoreceptors. MicroRNAs (miRNAs) are a group of endogenous noncoding RNA molecules that originate from parts of the genome that were originally speculated to be “junk” DNA. However, it is now known that these small RNA molecules are responsible for gene silencing on …
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Investigating Novel Targets to Inhibit Cancer Cell Survival
… cancer. Previous work in our laboratory using RNA interference screening identified genes that regulate the survival of glioblastoma (GBM) or autophagy in chronic myelogenous leukemia (CML) cancer cells. One screen identified Phosphatidylinositol-4,5-bisophosphate 3-kinase catalytic subunit …
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The Role of MicroRNAs in Craniofacial Development
… have been studied; however, the role of microRNA (miRNA) in mammalian palatal development has not been elucidated. miRNA are a class of short 19-21 nt noncoding RNA whose function is in the repression and attenuation of translation of their target mRNA. The function of specific miRNA is known …
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Analysis of Exome Sequencing in Hepatocellular Carcinoma
… histone H3k04 dimethylation had mutations in noncoding RNA processing and RNA metabolism in common. By the functional analysis from mutation studies of liver cancer, the profile of each subgroup was compared, and the functions related to tumor malignancy could be found.
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