Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Noncoding DNA"”.
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Single Cell Methods to Learn Transcription Factor Interactions and Necessary Noncoding DNA During Zebrafish Somitogenesis
… factors (TFs) and their interactions with noncoding regulatory DNA elements. However, our understanding of how these elements function in vivo and how TFs cooperate to drive cell fate decisions remains incomplete and limited in scope. In this thesis, I will present a method sciPlex …
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Rickettsia prowazekii and its ‘Junk DNA’: The Identification and Characterization of Small RNAs
… ~24% of the Rickettsia prowazekii genome was noncoding DNA due to genomic reduction. Regions of bacterial noncoding DNA were found to encode important post-transcriptional regulators of bacterial virulence and growth called bacterial small RNAs (sRNAs). These sRNAs are classified as either …
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Filter-based multiscale entropy analysis of complex physiological time series
… examine and compare the complexity of coding and noncoding DNA sequences.</p>
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Quantitative Characterization of Conserved Noncoding Regions by Flow Cytometry
… often involves regulatory sequences found in noncoding DNA separate from the gene’s promoter. Conservation of a noncoding region (CNR) across divergent species may indicate a regulatory region critical to basic morphogenesis. CNR-green fluorescent protein (GFP) constructs can demonstrate …
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Mutational Landscape of Noncoding Ultraconserved Elements in Human Cancers: Functional Relevance and Clinical Utility
… elements (UCEs), especially those in noncoding DNA regions (ncUCEs), and their functional and clinical relevance in cancers remain poorly characterized. In this thesis, we perform a systematic analysis of whole-genome sequencing (WGS) data from the International Cancer Genome …
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Quantifying evolution and natural selection in vertebrate noncoding sequence
… molecular evolution and selection that rely on noncoding sequence. Furthermore, our greater understanding of the importance of noncoding DNA demands such methods. This thesis contains the results of the first in-depth genomic-scale analysis using intron substitutions to estimate the neutral rate …
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Applications of genome editing for disease modeling in mice
… mammalian genome it is comprised of billions of DNA bases grouped into elements that we are beginning to understand (ie genes) and others we know little about (ie noncoding DNA). Forward and reverse genetics in cells and animal models is key to discovering causal mechanisms relating molecular and …
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Comparative genomics of repetitive elements between maize inbred lines B73 and Mo17
… sequences, including centromere, 45S ribosomal DNA (rDNA), knob, and telomere repeats. Genotype specific 45S rDNA sequences were discovered. The B73 and Mo17 polymorphic k-mers were used to examine allele-specific expression of 45S rDNA in the hybrids. Although Mo17 contains higher copy number …