Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"Noncanonical"”.
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Noncanonical NF-KB in Gastrointestinal Disease
Noncanonical NF-KB is an alternative NF-KB pathway that is critically involved in the development and maturation of the adaptive immune system. As such, it has typically been studied in B and T cell biology without application to complex organ systems such as the gut. The following work explores …
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Structural Insights into Noncanonical Mechanisms of Translation
… of translation can also proceed via a number of noncanonical mechanisms, many of which are vitally important for cellular growth or viral infectivity. My thesis describes structural insights into two such noncanonical mechanisms. The aim of the first project, described in Part II, was to …
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Mechanism and Functions of STING-Induced Noncanonical Autophagy
… activation of the pathway also induces noncanonical autophagy. Despite an increasing body of research on STING-induced noncanonical autophagy, our understanding of its mechanisms, and particularly its functions, remains limited. In this study, we demonstrated that STING-induced …
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The evolution and diversity of noncanonical microbial nitrogen metabolisms
… the evolution and nature of divergent or noncanonical nitrogen metabolisms. The first section of this work explores divergent enzymes of denitrification. I report a novel cytochrome-type nitrite reductase (nirS) structure within members of Phylum Chloroflexi, which includes a cytochrome …
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Dysregulation of Noncanonical NF-κB Signaling in Gastrointestinal Diseases
… canonical NF-κB pathway and the understudied noncanonical NF-κB pathway. The noncanonical NF-κB pathway is unique as it requires NIK, the NF-κB-inducing Kinase, to further elicit signal transduction of this pathway. Noncanonical NF-κB activation is critical to maintaining gut health, as …
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Influence of Kaempferol on Noncanonical DNA Structures and Protein Aggregation
… can serve as receptors for flavonoids. Noncanonical DNA motifs (such as C<sub>4</sub> and G<sub>4</sub> tetraplexes) are commonly found in human telomeres and protooncogenes, which can serve as potential targets to treat cancer. Therefore, since KMP has been implicated in crossing the …
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NONCANONICAL PYROPTOSIS PROMOTES NONALCOHOLIC STEATOHEPATITIS VIA LIPID PEROXIDATION AND TRAINED IMMUNITY
… in NAFLD, the role of the newly discovered noncanonical (caspase-11/-Gasdermin-Ddependent) pathway has not been defined. Diet-induced NAFLD promoted hepatic steatosis and lobular inflammation in male WT mice. Caspase-11 deficiency decreases macrovesicular steatosis and total NAFLD Activity …
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Noncanonical recognition and degradation of a stable soluble protein by AAA protease FtsH
… long degradation tag (degron) and then explore noncanonical recognition as one mechanism that may be employed in FtsH-dependent degradation. In Chapter I, I review our current understanding of AAA+ protease structure and function, especially as it pertains to FtsH to provide background for the …
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Paul's Use of Canonical and Noncanonical Wisdom Literature in Romans and the Corinthian Letters
… no one has compared his use of canonical and noncanonical wisdom literature. This present study sought to determine the nature of Paul's use of wisdom literature by comparing his use of canonical wisdom books (Job, Proverbs, and Ecclesiastes) with his use of noncanonical ones (Sirach and the …
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De novo design of passively permeable cyclic peptides and incorporation of noncanonical amino acids to improve predicted binding affinity
… computational methods for the incorporation of noncanonical amino acids at cyclic peptide binder interfaces to increase predicted binding affinity.
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The little engine that could: Characterization of noncanonical components in the speed-variable flagellar motor of the symbiotic soil bacterium Sinorhizobium meliloti
The bacterial flagellum is a fascinating corkscrew-shaped macromolecular rotary machine used primarily to propel bacterial cells through their environment via the conversion of chemical potential energy into rotational power and thrust. Flagella are the principal targets of complex chemotaxis …
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STRUCTURAL AND FUNCTIONAL DETERMINANTS OF CASPASE-11 INFLAMMASOME ASSEMBLY DURING INNATE IMMUNE DEFENSE
… organizing center (SMOC) designated the noncanonical inflammasome, where it is thought to undergo proximity-induced autoprocessing and become activated to mediate pyroptosis. Casp11 inflammasome assembly contributes to anti-microbial host defense but causes sepsis in murine models when …
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Regulation of Wnt signalling pathways by the Dishevelled DEP domain
… to Frizzled receptors to trigger canonical and noncanonical signalling responses that control cell fates during animal development and tissue homeostasis. All Wnt signals are relayed by the hub protein Dishevelled (DVL). During canonical (β-catenin dependent) signalling, Dishevelled assembles …
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Elucidating Human Inflammasome Responses To Legionella Pneumophila And Lipopolysaccharide Variants
… (IFN-) is a potent inducer of the both the noncanonical and canonical inflammasomes. Specifically, a family of IFN-inducible GTPases known as guanylate binding proteins (GBPs) promote inflammasome responses to a variety of bacteria in mice. The functions of the mouse GBPs include stimulating …
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NF-kB Inducing Kinase (NIK) Influences Eosinophil Development, Survival, and Plasticity
… cytokines. NIK is the upstream regulator of the noncanonical NF-kB pathway and is involved in lymphoid organ development, B cell lymphopoiesis, and myelopoiesis. In addition to regulating the noncanonical NF-kB pathway, NIK is also involved in regulation of kB dimers of the canonical NF-kB …
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Exploring the Forces Underlying the Dynamics and Energetics of G-quadruplexes with Polarizable Molecular Dynamics Simulations
G-quadruplexes (GQs) are highly stable noncanonical nucleic acid structures that form in the DNA of human cells and play fundamental roles in maintaining genomic stability and regulating gene expression. These unique structures exert broad influence over biologically important processes and can …
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Macrophage Polarization (M1/M2) and its Role in Wnt5a Secretion/Expression in Atherosclerosis
… lesions has been suggested. Wnt5a is a noncanonical member of the wingless family of proteins that is expressed in human macrophages in different inflammatory diseases including atherosclerosis. These observations led us to hypothesize that Wnt5a secretion/expression is related to M1 and …
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Interactions of Mammalian Retroviruses with Cellular MicroRNA Biogenesis and Effector Pathways
… virus expresses high levels of viral miRNAs via noncanonical biogenesis mechanisms. In contrast, the lentivirus human immunodeficiency virus type 1 (HIV-1) does not express any viral miRNAs in a number of cellular contexts. Comprehensive analysis of miRNA binding sites in HIV-1 infected cells …
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Bond activation and catalysis by nontrigonal tricoordinate and tetracoordinate phosphorus compounds
… kinetics and computational studies implicate a noncanonical, phosphorus-based electrophilic pathway for this transformation. As detailed in Chapter 3, a Cs-symmetric phosphorous triamide and its P-N cooperative reactivity are presented. B-H activation and catalytic imine hydroboration are …
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