Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 16 of 16 for “"Nonalcoholic steatohepatitis"”.
-
MOLECULAR DRIVERS OF DISEASE PATHOGENESIS IN NONALCOHOLIC STEATOHEPATITIS
… worldwide, with 25% of these patients developing nonalcoholic steatohepatitis (NASH). NASH is characterized by steatosis, inflammation, cell death, and liver fibrosis and significantly increases the risk of cirrhosis and decompensated liver failure. There are currently no approved drugs on the …
-
Nonalcoholic steatohepatitis (NASH) : animal studies of interactive hepatoxicity
The term "Nonalcoholic steatohepatitis" (NASH) describes a form of liver disease indistinguishable from alcoholic liver disease, but present in persons who consume insignificant amounts of alcohol. The spectrum of non-alcoholic liver disease ranges from non-progressive steatosis, through to NASH and …
-
NONCANONICAL PYROPTOSIS PROMOTES NONALCOHOLIC STEATOHEPATITIS VIA LIPID PEROXIDATION AND TRAINED IMMUNITY
Nonalcoholic fatty liver disease (NAFLD) is currently the most common cause of abnormal liver function in countries with western-style high fat, high cholesterol diets. Liver damage associated with NAFLD may lead to liver cirrhosis, end-stage liver disease and hepatocellular carcinoma (HCC). …
-
The unfolded protein response regulates hepatocellular injury during the pathogenesis of nonalcoholic steatohepatitis
Non-alcoholic steatohepatitis (NASH), which is characterized by the induction of hepatocellular death and inflammation, is associated with the activation of cellular stress pathways such as the Unfolded Protein Response (UPR), an adaptive response to disruptions in endoplasmic reticulum (ER) …
-
The role of "non-alcoholic steatohepatitis (NASH)" in methotrexate induced liver injury
… are nonspecific and may resemble those of nonalcoholic steatohepatitis (NASH). Moreover most of the risk factors of MTX induced liver injury are also associated with NASH. In this study serial liver biopsies of 24 psoriatic patients on lOng-term MTX were investigated to determine whether …
-
Aerobic exercise training as a mitigator of nonalcoholic fatty liver disease related fibrosis
… THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Nonalcoholic steatohepatitis (NASH) is a liver disease that is associated with obesity and is characterized by inflammation and fibrosis (scar tissue) within the liver. This condition is difficult to study in humans, therefore rodent models often …
-
The Role Of Crebh In Hepatic Energy Regulation Under Metabolic Stress
… and hypoketonemia and, partially, nonalcoholic steatohepatitis (NASH) in the CrebH-null mice developed under an atherogenic high-fat diet, corroborating the role of CREBH in regulating FGF21. In summary, my research demonstrated the transcriptional mechanism for CREBH in regulating …
-
The Roles of Activin A and B in Liver Inflammation and Fibrosis
… diseases, such as cholestatic liver disease and nonalcoholic steatohepatitis, among others. Fibrosis, if left unchecked, may progress to the point of cirrhosis – permanently affecting liver function detrimentally and potentially leading to development of hepatocellular carcinoma. Inflammatory …
-
Non-Alcoholic Fatty Liver Disease: Investigating the Impact of Bariatric Care and the Role of Immune Function
… (NAFLD) ranges from simple steatosis (SS) to nonalcoholic steatohepatitis (NASH) and cirrhosis. It is one of the most common causes of chronic liver disease resulting from obesity. 74-98% of morbidly obese individuals have NAFLD at the time of bariatric surgery. Post-bariatric surgery, NAFLD …
-
Dissecting The Roles of Trim24 In Regulation of Hepatic Lipid Metabolism and Inflammation
… populations that are commonly misregulated in nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH)<strong>.</strong> In the first part of my dissertation, I establish through global gene expression, chromatin enrichment, biochemical, and immunohistochemical analyses …
-
The role of caspase-1 in liver and adipose tissue during metabolic dysregulation in mouse models on NASH
… a benign non-progressive clinical course. Nonalcoholic steatohepatitis (NASH) is defined as lipid accumulation and cellular damage, inflammation and early to modest fibrosis. The progression of NAFLD to NASH remains incompletely understood. Therefore, dissection of mechanisms responsible …
-
Drug Metabolizing Enzyme, Drug Transporter Expression And Drug Disposition Are Altered In Models Of Inflammatory Liver Disease
… environmental factors such as disease states. Nonalcoholic fatty liver disease (NAFLD) is a chronic condition that comprises a spectrum of histopathologies that range from simple steatosis to the more severe steatohepatitis. Specifically, nonalcoholic steatohepatitis (NASH) has become one of …
-
Nash Alters Drug Metabolizing Enzyme and Transporter Expression Resulting in Significant Consequences for Pharmaceutical Disposition and Toxicity
… liver disease, to the occurrence of ADRs. Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease of industrialized nations. It represents a spectrum of damage progressing to the severe stage of nonalcoholic steatohepatitis (NASH), and is closely related to obesity and …
-
Discovery of Peptide and Aptamer Ligands for Targeted Drug Delivery to Hepatic Stellate Cells
… injuries, such as hepatitis, alcohol abuse, and nonalcoholic steatohepatitis, liver fibrosis is characterized by the excessive accumulation of extracellular matrix (ECM) in the liver. Activation of HSCs is the most critical step during liver fibrogenesis due to the production of excessive ECM and …
-
Using Telemedicine To Optimize The Delivery Of Care In Patients With Liver Disease
… the spectrum of liver diseases, non-alcoholic steatohepatitis (NASH) is the most common cause of cirrhosis and one of the top reasons for a liver transplant. Patients with NASH end up with hepatic decompensation and liver-related complications such as malnutrition, sarcopenia, frailty, and …
-
Mechanism of Hepatocyte Survival in Experimental Model of Non-Alcoholic Fatty Liver and Antioxidants Intake // Механизъм на хепатоцитно оцеляване при експериментален модел на неалкохолен мастен черен дроб и прием на антиоксиданти
Неалкохолната мастна чернодробна болест(НМЧБ) е най-разпространеното хронично чернодробно заболяване, свързана с нарастващата честота от затлъстяване, захарен диабет тип2, кардиометаболитни заболявания и се смята за неразделна част от метаболитния синдром. НМЧБ е клинико-патологичен синдром със …