Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Nonalcoholic fatty liver disease (NAFLD)"”.
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THE EFFECTS OF ESTROGENIC COMPOUNDS ON ADIPOGENESIS VIA PPARγ AND CANONICAL WNT SIGNALING
… including type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD) have become a major public health concerns. These complications primarily arise in response to cellular changes in white adipose tissue (WAT). In particular, when a majority of fat cells become hypertrophic …
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NONCANONICAL PYROPTOSIS PROMOTES NONALCOHOLIC STEATOHEPATITIS VIA LIPID PEROXIDATION AND TRAINED IMMUNITY
Nonalcoholic fatty liver disease (NAFLD) is currently the most common cause of abnormal liver function in countries with western-style high fat, high cholesterol diets. Liver damage associated with NAFLD may lead to liver cirrhosis, end-stage liver disease and hepatocellular carcinoma (HCC). …
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Nash Alters Drug Metabolizing Enzyme and Transporter Expression Resulting in Significant Consequences for Pharmaceutical Disposition and Toxicity
… a person susceptible to ADRs are genetics and disease; however, genetics account for only a small proportion. This dissertation is focused on the contribution of an environmentally-derived component, particularly liver disease, to the occurrence of ADRs. Nonalcoholic fatty liver disease (NAFLD) …
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Dissecting The Roles of Trim24 In Regulation of Hepatic Lipid Metabolism and Inflammation
… lipid accumulation, inflammation, and damage of liver tissue, due to complete loss of <em>Trim24 </em>expression. In human HCC and other cancers, TRIM24 expression is aberrantly high, while deletion of TRIM24 in the mouse has been shown to act as a liver specific tumor suppressor. The hypothesis …
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Drug Metabolizing Enzyme, Drug Transporter Expression And Drug Disposition Are Altered In Models Of Inflammatory Liver Disease
… the body. For the vast majority of drugs, the liver plays a key role in determining the rate at which drugs are eliminated. First, drugs must be taken up across the cell membrane into hepatocytes by uptake transporters. Once inside the hepatocyte, biotransformation enzymes metabolize and …
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PKC-δ and Insulin Resistance in Non-Alcoholic Fatty Liver Disease: Effect of Vitamin D
ABSTRACT|Nonalcoholic fatty liver disease (NAFLD) due to excess ectopic fat deposit in the liver of nonalcoholic is a broad spectrum of liver diseases encompassing simple liver steatosis to more complicated and morbid steatohepatitis (NASH) that can lead to cirrhosis and even to hepatocellular …
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The association of prematurity and medical conditions with the gut microbiome of mammals
… relationship is thought to contribute to disease development. This thesis encompasses three studies, centred around the impact of nutritional supplementation on the gut microbiome of preterm lambs, infants born moderate-late preterm (MLPT) and adults diagnosed with nonalcoholic fatty liver …
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The Metabolic Impact of the Gut-Liver Bile Acid Signaling in Metabolic and Inflammatory Liver Disease
… the terminal ileum and transported back to the liver via the portal circulation. Bile acids circulating in the enterohepatic circulation play important roles in maintaining bile acid, lipid and glucose homeostasis and inflammatory response. Disruption of bile acid homeostasis could contribute to …
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Mechanism of Hepatocyte Survival in Experimental Model of Non-Alcoholic Fatty Liver and Antioxidants Intake // Механизъм на хепатоцитно оцеляване при експериментален модел на неалкохолен мастен черен дроб и прием на антиоксиданти
Неалкохолната мастна чернодробна болест(НМЧБ) е най-разпространеното хронично чернодробно заболяване, свързана с нарастващата честота от затлъстяване, захарен диабет тип2, кардиометаболитни заболявания и се смята за неразделна част от метаболитния синдром. НМЧБ е клинико-патологичен синдром със …
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The UP AMIGOS project: Testing the predictive validity of the 2007 Pediatric Expert Committee Recommendations in Latinos
… disproportionately affected by cardiovascular disease and there is mounting evidence that Mexicans may be genetically prone to the development of cardiovascular disease (CVD) risk factors. Objective. There were three aims of study. The first aim was to identify the prevalence of three CVD risk …