Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 21 for “"Nonalcoholic fatty liver disease"”.
-
Aerobic exercise training as a mitigator of nonalcoholic fatty liver disease related fibrosis
… THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Nonalcoholic steatohepatitis (NASH) is a liver disease that is associated with obesity and is characterized by inflammation and fibrosis (scar tissue) within the liver. This condition is difficult to study in humans, therefore rodent models often …
-
Dissecting The Roles of Trim24 In Regulation of Hepatic Lipid Metabolism and Inflammation
… lipid accumulation, inflammation, and damage of liver tissue, due to complete loss of <em>Trim24 </em>expression. In human HCC and other cancers, TRIM24 expression is aberrantly high, while deletion of TRIM24 in the mouse has been shown to act as a liver specific tumor suppressor. The hypothesis …
-
THE EFFECTS OF ESTROGENIC COMPOUNDS ON ADIPOGENESIS VIA PPARγ AND CANONICAL WNT SIGNALING
… including type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD) have become a major public health concerns. These complications primarily arise in response to cellular changes in white adipose tissue (WAT). In particular, when a majority of fat cells become hypertrophic …
-
Nonalcoholic steatohepatitis (NASH) : animal studies of interactive hepatoxicity
The term "Nonalcoholic steatohepatitis" (NASH) describes a form of liver disease indistinguishable from alcoholic liver disease, but present in persons who consume insignificant amounts of alcohol. The spectrum of non-alcoholic liver disease ranges from non-progressive steatosis, through to NASH and …
-
NONCANONICAL PYROPTOSIS PROMOTES NONALCOHOLIC STEATOHEPATITIS VIA LIPID PEROXIDATION AND TRAINED IMMUNITY
Nonalcoholic fatty liver disease (NAFLD) is currently the most common cause of abnormal liver function in countries with western-style high fat, high cholesterol diets. Liver damage associated with NAFLD may lead to liver cirrhosis, end-stage liver disease and hepatocellular carcinoma (HCC). …
-
Berries in Prevention of Metabolic Disease – focus on obesity, diabetes and gut microbiota
… disorders including insulin resistance, nonalcoholic fatty liver disease and type 2 diabetes. Hence, there is a great need to identify dietary strategies for the prevention of obesity and related diseases. This thesis investigates the potential of different berries to mediate beneficial …
-
Drug Metabolizing Enzyme, Drug Transporter Expression And Drug Disposition Are Altered In Models Of Inflammatory Liver Disease
… the body. For the vast majority of drugs, the liver plays a key role in determining the rate at which drugs are eliminated. First, drugs must be taken up across the cell membrane into hepatocytes by uptake transporters. Once inside the hepatocyte, biotransformation enzymes metabolize and …
-
Nash Alters Drug Metabolizing Enzyme and Transporter Expression Resulting in Significant Consequences for Pharmaceutical Disposition and Toxicity
… a person susceptible to ADRs are genetics and disease; however, genetics account for only a small proportion. This dissertation is focused on the contribution of an environmentally-derived component, particularly liver disease, to the occurrence of ADRs. Nonalcoholic fatty liver disease (NAFLD) …
-
Shortwave infrared imaging and its translation to clinically-relevant designs
… describe fluorescence detection of an endogenous disease biomarker in animal models including nonalcoholic fatty liver disease and cirrhotic liver models and models of a neurodegenerative disease pathway. While this biomarker has been known for decades, we describe a method for its noninvasive …
-
PKC-δ and Insulin Resistance in Non-Alcoholic Fatty Liver Disease: Effect of Vitamin D
ABSTRACT|Nonalcoholic fatty liver disease (NAFLD) due to excess ectopic fat deposit in the liver of nonalcoholic is a broad spectrum of liver diseases encompassing simple liver steatosis to more complicated and morbid steatohepatitis (NASH) that can lead to cirrhosis and even to hepatocellular …
-
Branched-Chain Amino Acid Metabolism in the Neonatal Pig
… experimental diets had no effect on adiposity, liver fat accumulation, or expression of genes related to fatty acid synthesis, mitochondrial biogenesis, or energy expenditure in the pigs' livers. Having produced strong evidence that long term BCAA supplementation neither improves lean growth nor …
-
Autophagy and Lipid Homeostasis in C. elegans
… risk of metabolic disorders including heart disease, insulin resistance, type 2 diabetes and nonalcoholic fatty liver disease. Therefore it is no surprise that lipid-related metabolic disorders have become a significant burden to our healthcare system. In recent years, the conserved cellular …
-
The association of prematurity and medical conditions with the gut microbiome of mammals
… relationship is thought to contribute to disease development. This thesis encompasses three studies, centred around the impact of nutritional supplementation on the gut microbiome of preterm lambs, infants born moderate-late preterm (MLPT) and adults diagnosed with nonalcoholic fatty liver …
-
Leptin and the Control of Body Weight and Metabolism: Role for Stearoyl CoA Desaturase-1 and Other Leptin-Regulated Genes in the Liver
… in multiple peripheral organs, including the liver, massively enlarged and steatotic. Leptin elicits a metabolic response that cannot be explained by its anorectic effects alone. This response is characterized by weight loss, depletion of lipid from peripheral tissues, and enhanced insulin …
-
The Metabolic Impact of the Gut-Liver Bile Acid Signaling in Metabolic and Inflammatory Liver Disease
… the terminal ileum and transported back to the liver via the portal circulation. Bile acids circulating in the enterohepatic circulation play important roles in maintaining bile acid, lipid and glucose homeostasis and inflammatory response. Disruption of bile acid homeostasis could contribute to …
-
High fat diet causes hepatic lipid accumulation by programming lipid synthesizing genes via gene body methylation
… at 12 weeks of age, and the left lobe of the liver was used for further analysis. In model 1, liver histology showed greater hepatic fat accumulation in the C/HF group. Gene expression data was measured for multiple genes in the following pathways: glycolysis, gluconeogenesis, fatty acid …
-
ALTERAZIONE DEL miRNoma INTRACELLULARE ED EXTRACELLULARE ED ANALISI BIOINFORMATICA IN MODELLI IN VITRO DI NAFLD E DI NASH
La steatosi epatica non alcolica (Non-alcoholic fatty liver disease NAFLD) interessa circa il 20-30% della popolazione generale e rappresenta la malattia epatica cronica più comune nei paesi industrializzati. La NAFLD presenta un potenziale evolutivo, attraverso la fase infiammatoria denominata …
-
Mechanism of Hepatocyte Survival in Experimental Model of Non-Alcoholic Fatty Liver and Antioxidants Intake // Механизъм на хепатоцитно оцеляване при експериментален модел на неалкохолен мастен черен дроб и прием на антиоксиданти
Неалкохолната мастна чернодробна болест(НМЧБ) е най-разпространеното хронично чернодробно заболяване, свързана с нарастващата честота от затлъстяване, захарен диабет тип2, кардиометаболитни заболявания и се смята за неразделна част от метаболитния синдром. НМЧБ е клинико-патологичен синдром със …
Page 1 of 2