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Global ETD Search

Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 98 for “"Non-small cell lung cancer (NSCLC)"”.

  1. Immunotherapeutic approaches for ALK-driven Non-Small-Cell Lung Cancer (NSCLC)

    Chiarle, Roberto, Bussolino, Federico, Frutuoso E Ferreira Mota, Ines SofiaUniversità degli Studi di Torino2020

    unito Repository record

  2. 3D-printed cell culture system as an in vitro platform for non-small cell lung cancer (NSCLC) modeling

    Meiburger, Kristen Mariko, Terzini, Mara, Baruffaldi, DesireeUniversità degli Studi di Torino2023

    unito Repository record

  3. Cost-utility analysis of EML4-ALK fusion testing followed by treatment with crizotinib in patients with Non-Small Cell Lung Cancer (NSCLC)

    Girish Pai, Shweta2016

    Objective NSCLC is the most common type of lung cancer and accounts for about 85% of all lung cancers. Currently a majority of patients with NSCLC are treated with surgical resection and/or cytotoxic drugs. Chemotherapy has resulted in a modest increase (median survival of 8 months with …

    washington Repository record

  4. Molecular testing for predictive purposes of epidermal growth factor receptor (EGFR) gene mutations in advanced Non Small Cell Lung Cancer (NSCLC) patients

    Piva, Roberto, Di Bello, CristianaUniversità degli Studi di Torino2019

    unito Repository record

  5. Dissecting the Role of Enhancer of Zeste Homolog 2 (EZH2) in Neuroendocrine Transdifferentiation (NE-TD) in Non-Small Cell Lung Cancer (NSCLC) of Epithelial Origin.

    Alsubaie, Abduljalil Mohammed2024

    gmu

  6. To evaluate the role of miRNAs as potential diagnostic and prognostic biomarkers for Asbestos-related interstitial lung diseases (ILD), Non-Small Cell Lung Cancer (NSCLC) and Malignant Pleural Mesothelioma (MPM)

    MUKHOPADHYAY, DEBRAJUniversità degli Studi di Cagliari2026

    … is still the leading cause of occupational cancer mortality worldwide. Asbestos-related lung cancer (LC) and malignant pleural mesothelioma (MPM) prognosis is still poor especially at advanced stage, which highlights the need for early diagnosis and effective biomarkers capable of detecting …

    cagliari Repository record

  7. STRUCTURE-ACTIVITY RELATIONSHIPS IN FUNCTIONALIZED PLATINUM-ACRIDINE ANTICANCER AGENTS

    Graham, Leigh AnnWake Forest University2012

    … reported that shows high activity in NCI-H460 non-small-cell-lung cancer (NSCLC) both in vitro and in vivo, but has proven to have high systemic toxicity (nephrotoxicity). In order to reduce the toxicity of this agent, two new methodologies were developed to reduce unwanted platinum …

    wfu Repository record

  8. Elucidating the Target and Selectivity of a Non-Small Cell Lung Cancer Toxin

    Madhusudhan, Nikhil2021

    Selective toxicity among cancer cells of the same lineage is a hallmark of targeted therapies, and so identifying compounds that impair proliferation selectively is an important strategy in drug development. Here, we report the discovery of the quinazoline dione compound (QDC), a molecule that …

    utswmed Repository record

  9. Investigation of the Biological Effects of Rosemary (Rosmarinus Officinalis L.) Extract in Human Lung Cancer Cells

    Moore, JessyBrock University2015

    Cancer cells display enhanced growth rates and a resistance to apoptosis. Lung cancer accounts for the most cancer related deaths and non-small cell lung cancer (NSCLC) represents an aggressive form of lung cancer, accounting for almost 80% of all lung cancer cases. The phytochemical rosemary …

    brock Repository record

  10. NOVEL APPROACHES FOR CONTROLLING TARGET SELECTIVITY AND PHARMACOLOGICAL PROPERTIES OF PLATINUM-INTERCALATOR-BASED ANTICANCER AGENTS

    Pickard, Amanda JayneWake Forest University2014

    Traditional DNA-targeted anticancer agents, such as platinum-based therapies, have been a mainstay in the treatment of aggressive solid malignancies in the clinical setting. Unfortunately, due to multifactorial drug resistance and systemic toxicity the clinical efficacy of these drugs is severely …

    wfu Repository record

  11. AXL Targeting Restores PD-1 Blockade Sensitivity of STK11/LKB1 Mutant NSCLC Through Expansion of TCF1+ CD8 T Cells

    Li, Huiyu2024

    Mutations in STK11/LKB1 in non-small cell lung cancer (NSCLC) are associated with poor patient responses to immune checkpoint blockade (ICB) for unknown reasons. We found that introduction of a Stk11/Lkb1 (L) mutation into murine lung adenocarcinomas driven by mutant Kras and Trp53 (KP) resulted in …

    utswmed Repository record

  12. Dissecting The Molecular Mechanism of Early Tumor Dissemination In Non-Small Cell Lung Cancer

    Liu, Xingtong, <p>https://orcid.org/0000-0002-1161-7976</p>2020

    <p>Lung cancer is the most common cause of cancer related death in the United States and worldwide. It has been shown that 30%-55% of patients with early stages of non-small cell lung cancer (NSCLC) developed and died of recurrence after curative resection, suggesting that tumor cell dissemination …

    uthsc Repository record

  13. Chemotherapy for lung cancer: Determinants of guideline adherence and associated patient outcomes

    Salloum, Ramzi George2011

    … for medically fit patients with stage II-IV non-small cell lung cancer (NSCLC). Adherence to chemotherapy guidelines has rarely been studied among large populations, mainly because performance status (PS), a key component in assessing chemotherapy appropriateness, is missing from claims-based …

    wayne-thes Repository record

  14. Innovative Methods for Outcome-Based Pricing of Treatments from the US Payer Perspective (The Six Delta Platform)

    Alkhatib, NimerThe University of Arizona.2020

    … is provided for osimertinib in the treatment of non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutation.

    arizona-thes Repository record

  15. Prognostic Factor Analysis of Patients with Advanced Non-Small Cell Lung Cancer Treated with Palliative Chemotherapy

    최, 용원2011

    … the most important cause of treatment failure in non small cell lung cancer (NSCLC). MATERIALS AND METHODS: Pretreatment tumor biopsy specimens from 50 patients with NSCLC stage IIIB with malignant pleural effusion or stage IV were analyzed for p53, Bcl-2, Bax and ERCC1 expression by …

    ajou Repository record

  16. Intervention of non-small cell line cancer oncogenic pathways with delta-tocotrienol

    Ji, Xiangming2012

    <p>Non-small cell lung cancer (NSCLC) is most hostile and leading cause of cancer deaths in the United States. Clinical data has demonstrated that 30 % of NSCLC patients have increased Notch activity and 10% of NSCLC have gain-of-function mutation on Notch-1 gene. Our data demonstrated that …

    wayne-thes Repository record

  17. Determining Mechanisms of Response to Polo-Like Kinase 1 Inhibition In Non-Small Cell Lung Cancer

    Goonatilake, Ruchitha2017

    <p>Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. The discovery of genetic alterations in some patients (~15%) has made it possible to use targeted therapies without the use of chemotherapy. To identify potential therapeutic targets in NSCLC, we …

    uthsc Repository record

  18. Applying Canadian patient wait time benchmarks to diagnostic CT examinations for non-small cell lung cancer in American healthcare

    Ballou, Ryan2025

    … (CT), such as imaging and guided biopsies for non-small cell lung cancer (NSCLC), resulted in larger and more advanced stage tumors. In this study, patients had to wait approximately 81 days between those two procedures, and as a result, their prognoses and quality of life significantly …

    bu Repository record

  19. Associations between Selected Dietary Factors, Selected Obesity-Related Metabolic Markers (Leptin, C-peptide, and High-sensitivity C-reactive Protein), and Lung Cancer: A Matched Case-Control Study Nested in the Prospective PLCO Trial

    Chen, YixianBrock University2019

    … selected obesity-related metabolic markers, and lung cancer risk as well as histological types in ever-smokers (former and current-smokers). Characteristics of interest included BMI at age 50, fruits and vegetables daily frequency, supplemental beta-carotene intake, C-peptide (CP), …

    brock Repository record

  20. Identifying the Molecular Mechanism of TAZ-Induced Lung Tumorigenesis

    Alharbi, Adel2014

    … plays critical roles in organ size control, stem cell self-renewal, tumorigenesis and drug resistance. Recently, TAZ has been identified as a novel oncogene that is overexpressed in non-small cell lung cancer (NSCLC) cells and mediates their proliferation, transformation and tumorigenesis. …

    queens Repository record

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