Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Non-shivering thermogenesis"”.
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Energy metabolism and aging
… adipose tissue (BAT), which is responsible for non-shivering thermogenesis. Our laboratory has already demonstrated functional alterations in visceral adipose tissue of Ames dwarf mice, and given the altered energy metabolism of Ames dwarf mice, we hypothesized that BAT may also be functionally …
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AQP1—A REGULATORY FACTOR ASSOCIATED WITH BROWN ADIPOSE TISSUE SILENCING TO COMBAT OBESITY AND METABOLIC DISEASE
The activation of non-shivering thermogenesis (NST) in brown adipose tissue (BAT) by environmental cold challenge yields strong metabolic benefit in the face of diet-induced obesity (DIO). Yet, a critical barrier to leveraging brown fat NST for therapeutic use against metabolic disease is that BAT …
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SIMILAR EFFECTS OF COLD ADAPTATION AND EXERCISE TRAINING ON GROWTH, MAXIMUM AEROBIC CAPACITY, AND METABOLISM IN YOUNG RATS
<p>The exact processes underlying dietary-induced thermogenesis (DIT) are unknown. Current research has suggested that DIT and non-shivering thermogenesis (NST) may share common thermoregulatory pathways. If that is so, variables that are known to affect DIT should also affect NST, and vice versa. …
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A Network Approach to Understanding miRNA Regulation in Adipose Tissue
… factors that govern adipogenesis, inflammation, non-shivering thermogenesis, and endocrine function in fat tissue have been well-described, comparatively less attention has been given to post-transcriptional regulators. Here, we employ two contrasting approaches to identify miRNAs that influence …
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The Role of Thada in Energy Homeostasis
… envisaged THADA could contribute to the muscle non-shivering thermogenesis—in addition to sarcolipin, another uncoupler of SERCA. Our working hypothesis was reinforced by the fact that mutations in THADA have been positively selected during the last 45-30K years in the Arctic populations, which …
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Thermoregulation, hibernation and reproduction in the South African hedgehog Erinaceus frontalis A. Smith
… African hedgehog has the ability to hibernate. Non-shivering thermogenesis does occur in this species. During July when the ambient temperature dropped to 8 °c the frequency of activity was low. During the following sessions the frequency of activity became increasingly higher. Aspects of …
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A Human Pluripotent Stem Cell-Derived Model for the Investigation of Thermogenic Adipocyte Development and Function
… tissue (WAT) in order to fuel the process of non-shivering thermogenesis and burn nutrients as heat. Thus, mechanisms to safely activate BAT and thereby increase energy expenditure could represent promising anti-obesity therapeutics. The challenge is to identify a way to increase energy …
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The hormonal control of lipid metabolism in sheep
… could be recycled within the tissue, a phenomenon which is under hormonal control and is possibly linked with maintenance of non-shivering thermogenesis. Insulin stimulated the rate of lipogenesis (from acetate) by up to 6-fold, with the average stimulation about 70%, but it failed to affect …
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Muscle adaptations to post-exercise cooling
… activity (p < 0.05) while not resulting in shivering thermogenesis. While these responses may improve local muscle recovery, its simultaneous effect is on muscle aerobic adaptations are unclear. Indeed, reduced muscle metabolism might attenuate mitochondrial biogenesis via inhibiting AMPK …
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Structure and regulatory mechanism of human uncoupling protein 1
Uncoupling protein 1 (UCP1) in the mitochondrial inner membrane is responsible for the thermogenic properties of brown adipose tissue. In response to cold exposure, UCP1 is activated by free fatty acids and catalyses proton leak, dissipating the proton motive force, which mitochondria use to drive …