Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Non-natural amino acids"”.
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Developing Novel Non-Natural Amino Acids as Spectroscopic Reporters of Structure for Peptide Systems
Properly folded proteins are essential to living organisms. Mis-folded proteins can lead to some serious diseases such as Alzheimer's disease, Lou Gehrig's disease (ALS), and muscular dystrophy which affect many people. The key to potentially preventing such diseases lies in understanding how and …
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Synthesis of Epidermal Growth Factor by Native Chemical Ligation and Incorporation of Non-Natural Amino Acids
… of analogs of hEGF and to incorporate unnatural amino acids into EGF and its fragments. Since the analogs share sequences, for optimal versatility and economy, it was decided that hEGF would be assembled from fragments which could be used as building blocks in the synthesis of several …
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Synthesis of non-natural amino acids, peptidomimetics, and electrochemical characterization of the structures obtained by self-assembly
L'uso di amminoacidi (AA) non naturali, tra i quali i β-AA, per la sintesi di peptidomimetici riscuote sempre più interesse, poiché si tratta di sequenze con la stessa attività biologica dei peptidi naturali ma con una maggiore stabilità proteolitica e conformazionale. Inoltre, la capacità dei …
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Protein and Peptide Solubility - In Silico and In Vitro Approaches
… solubility of proteins and peptides containing non-natural amino acids and to incorporate the effects of formulation pH. A particularly exciting aspect of this project concerning the translation into industrial applications, is that it was carried out in collaboration with AstraZeneca. The …
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Beta-o-glicosilación de péptidos que incorporan aminoácidos no naturales
… aqueous solution of different alpha-methyl-alpha-amino acid diamides, derived from serine (Ser), threonine (Thr), beta-hydroxyciclobutane-alpha-amino acids and their corresponding model beta-O-glycopeptides, are reported. From this study, it can be concluded that the incorporation of non-natural …
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INVESTIGATIONS IN IRON, COPPER, AND PALLADIUM –CATALYZED C-H BOND FUNCTIONALIZATION
… functionalization of sp3 C-H bonds in amino acid derivatives using auxiliary-assisted palladium-catalyzed methodology is also demonstrated. A method for iron-catalyzed alkylation of arenes and heterocycles containing acidic C-H bonds has been developed. Various heterocycles such as …
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Analyzing Functional Interactions of Designed Peptides by NMR Spectroscopy
… application incorporated arginine as cationic amino acids and non-natural amino acids that have aromatic side chains with similar hydrophobic properties as tryptophan. The interaction of lead cyclic peptides and their linear analogs with a phospholipid bilayer mimicking a bacterial membrane was …
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Smart Nanomaterials from Repeat Proteins and Amyloid Fibrils
… important area of research for various reasons. Natural protein materials such as spider silk have mechanical properties which compare favourably to artificial or inorganic materials, and in addition are biodegradable and can be produced from easily available feedstocks. It is also possible to …