Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 79 for “"Non-invasive imaging"”.
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Assessment of aortic stenosis using modern non-invasive imaging techniques
… of aortic valve narrowing. Conclusions. Modern imaging techniques have provided important insights in to the pathology underlying aortic stenosis and suggest that valvular calcification and myocardial fibrosis have a key role. Both represent important potential targets for future therapeutic …
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Advanced optical microscopy toolkits for non-invasive imaging in oncology
… To study such dynamics at the microscale, non-invasive optical toolkits offer the potential to identify, characterize, and visualize key molecules and their interactions in their native biological context, ranging from in vitro cell cultures to in vivo studies in both animal models and …
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The design, synthesis and evaluation of selective, non invasive imaging agents for atherosclerotic plaque.
… of this research study was the synthesis of an imaging agent, which could be used to non-invasively image atherosclerotic plaques via MRI. In order to achieve this, a library of peptide substrates designed to be substrate specific for either legumain or MMP-2/9 were synthesized. This was …
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Establishing a Model of Organ regeneration in the Adult Mammal: Age Dependence and the Utility of Non-Invasive Imaging
… regeneration, and the prognostic value of non-invasive imaging were evaluated. Removal of a large portion of the urinary bladder (subtotal cystectomy; STC) in adult rats initiated a proliferative response that gave rise to normal bladder wall architecture, including nerves, vessels, …
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Characterizing Changes in T Cell Composition and Function Within Prostate Tumors Following Androgen Ablation and Non-invasive Imaging of Anti-Tumor Immune Responses
… prostate cancer because as an immunogenic, non-vital organ, collateral prostate tissue damage is not life threatening. We set out to characterize the prostate infiltrating lymphocytes following androgen ablation as well as at later time points using standard immunohistochemical techniques. …
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Ultrasound tissue displacement and tissue elasticity imaging
… tissue motion and tissue elasticity for medical imaging applications. Ultrasound provides a means for non-invasive imaging of soft tissues, providing soft tissue contrast that cannot be achieved using conventional X-ray or tomographic imaging.
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Development of a novel imaging system for cell therapy in the brain.
… of a reliable and safe method to accurately and non-invasively locate the site of implantation and track the migration of stem cells in vivo hampers the development of stem cell therapy and its clinical application. The long-term goal of my research is to study the potential of stem cell therapy …
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Dynamic Digital Optical Tomography for Cancer Imaging and Therapy Monitoring
Diffuse optical tomography is a non-invasive imaging technique that uses near-infrared light to create three-dimensional images of tissue. This dissertation presents the design and validation of an instrument for rapid optical imaging using digital detection techniques. In addition to a detailed …
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Large-scale high-density terahertz radiator and receiver Arrays on silicon chips
… THz) have important applications in gas sensing, non-invasive imaging, short-range ultra-high-data-rate wireline/wireless communications. Historically, due to their speed limit, silicon-based transistors are unable to reach this frequency range, so terahertz systems were built upon high- cost …
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Virtual autopsy: Μπορεί να αντικαταστήσει τη συμβατική νεκροψία-νεκροτομή; Σύγκριση της αποτελεσματικότητας των ελάχιστα ή μη επεμβατικών απεικονιστικών μεθόδων με την κλασική νεκροτομή για τον προσδιορισμό της αιτίας θανάτου / Virtual autopsy: Can it replace the conventional autopsy? A comparative evaluation of the effectiveness of minimally or non-invasive imaging modalities versus conventional autopsy in determining the cause of death
Η νεκροψία–νεκροτομή αποτελεί διαχρονικά τη μέθοδο αναφοράς για τον προσδιορισμό της αιτίας θανάτου, τόσο σε κλινικό όσο και σε ιατροδικαστικό πλαίσιο. Ωστόσο, τα τελευταία έτη παρατηρείται διεθνώς σημαντική μείωση των ποσοστών διενέργειάς της, λόγω ηθικών, θρησκευτικών, κοινωνικών και πρακτικών …
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Investigation of Machine-Learning Techniques for Pulmonary Artery Pressure Estimation from Electrical Impedance Tomography Images
… is the measurement of PAP using a continuous and non-invasive imaging modality - electrical impedance tomography (EIT). Previous work used a model-based algorithm relying on the known association between thoracic conductivity changes and PAP. This thesis attempted to improve these results by …
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Image-Based Morphological Modeling of Soft and Bony Tissue with Applications in Prognostics and Medical Device Design
Improvements in non-invasive imaging and three-dimensional visualization techniques permit highly detailed morphological analyses of internal organs. Morphometric quantification of bony and soft tissue anatomy from computed tomography (CT) and magnetic resonance 1 images is used to quantify shape …
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Optical coherence tomography applied to investigations of optical properties of paintings
… thesis, the various applications of OCT to the non invasive imaging of paintings are explored in detail. The spectral reflectance and transparency of a variety of historic artists’ pigments in linseed oil or egg tempera medium are investigated and the best spectral window is found for OCT …
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Stochastic Actor-Oriented Models of Functional and Structural Human Brain Networks in Aging
… system that changes throughout the lifetime. Non-invasive imaging techniques, including magnetic resonance imaging (MRI), allow for the measurement of large-scale functional and structural connectivity networks in the brain. Beyond trends, the dynamics across long timescales are still poorly …
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Imaging Biomarkers of Response to Immune Checkpoint Inhibition in Melanoma
… for this treatment approach. The development of non-invasive imaging methods and imaging biomarkers of response to immune checkpoint inhibitors could therefore provide important diagnostic and prognostic information. This project builds on existing technologies in Cambridge to develop structural …
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Spatiotemporal Encoding Methods for Brain Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is a widely used non-invasive imaging technology for both clinical diagnosis and neuroscientific research. However, the imaging sensitivity and specificity of brain MRI are limited by the well-known technical challenge of MRI acquisition—low image encoding …
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Papildomas adenozino vaidmuo mažinant infarkto dydį ir išsaugant kairiojo skilvelio funkciją pacientams, sergantiems ūminiu miokardo infarktu /
… manifestation of slow-reflow or no-reflow phenomenon. The results of reperfusion therapy with adjunctive adenosine and without adenosine were analyzed in two homogeneous patient groups. By using new non-invasive imaging methods (single photon emission computer tomography, transthoracic Doppler …
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Handheld MRI for Point-of-Care and Educational Applications
Magnetic Resonance Imaging (MRI) is a powerful, non-invasive imaging modality for visualizing the body’s internal anatomy and providing contrast between soft tissues. However, the reach of clinical MRI scanners is limited by their expensive infrastructure (millions of USD), including radiofrequency …
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Design and development of a 3D X-ray microscope
… injection systems demands better and faster imaging systems, capable of imaging the transient and steady state response of an injection into real tissue. X-ray radiography, x-ray microscopy, and computerized tomography (CT) were identified as the most appropriate imaging techniques used for …
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