Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Non-human primate model"”.
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A non-human primate model of dorsolateral prefrontal cortex dysfunction in schizophrenia
… et al., 2013). Our aim was to use a marmoset model to investigate how degrading PNNs in the dlPFC affected SWM, as well as additional behaviours, cognitive functions, and brain function relevant to schizophrenia. In Chapter 3, I describe the development and validation of a SWM task for …
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A Comparative Study of the Pathology and Pathophysiology of Severe Malaria in a Non-Human Primate Model
… a predilection for use of less than ideal murine models, the need for effective, applicable and established animal models through which to understand severe malarial disease and test potential treatments is becoming increasingly crucial. Plasmodium coatneyi was discovered in the Philippines in the …
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Efficacy of using robotics to characterize impaired upper-limb function in a non-human primate model of stroke
… animal preclinical trials failed in subsequent human populations. Non-human primates (NHPs) closely resemble humans and may represent an animal model that could help bridge the translational gap preceding clinical trials. Additionally, robotic technology has been proven to provide objective …
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Characterization and Development of a Novel Cytomegalovirus for Evaluation as an HIV Vaccine Viral Vector in a Non-Human Primate Model
… to evaluate CMV-based HIV/SIV vectors in a non-human primate (NHP) model, I isolated CMV from cynomolgus macaques (CyCMV), and performed preliminary phenotypic and genomic classification of the novel virus. To characterize the CyCMV genome, facilitate targeted recombination for vaccine …
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The Cholesterol Transporter ABCA1 and Cholesterol Accumulation are Key Regulators of Adipose Function in Obesity
… understudied. This thesis presents two models to study adipose cholesterol. The first used a non-human primate model to determine the effect of additional dietary cholesterol on adipose tissue depots, and the second uses an adipose specific knock out of ATP Binding Cassette Transporter …
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Developing In Vitro and In Vivo Models for Lyme Neuroborreliosis (LNB)
… due to the lack of a suitable experimental model. The non-human primate model for LNB presents significant impediments, such as high costs, specialized training, ethical considerations, and low infection frequency. Finding alternative models is imperative to advance LNB research. This study …
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Host and viral determinants of flavivirus emergence and pathogenesis
… harm comparable to Zika virus (ZIKV) in a mouse model of flavivirus pathogenesis during pregnancy and that SPONV can be transmitted by Aedes aegypti mosquitoes. In Chapter 3, I further characterize SPONV pathogenesis with the development of a non-human primate model of SPONV infection in …
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Characterising trait anxiety in the common marmoset (Callithrix jacchus): investigations into behavioural, psychophysiological and cognitive phenotypes
… aim of my thesis project has been to develop a non-human primate model of trait anxiety, using a new world monkey, the common marmoset. The first step was to identify animals high or low in trait anxiety. Based on the findings that high trait-anxious individuals display over-generalization of …
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The Role of Bone Morphogenetic Protein Signalling in Adult Lung Health and Disease
… in the descending airways of large animal models and to investigate the role of BMP signalling during adult airway homeostasis, recovery and disease. To investigate the role of BMP signalling in malignant lung disease we used a heterogeneous lung cancer cell line DLKP. We explored the …
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Cerebral blood flow in the non-human primate : an in vivo model and drug interventions
… and dementia. Due to the similarities between humans and non-human primates with respect to their brains, both structurally and behaviourally, numerous studies have been conducted and several non-human primate models have been developed for physiological, pathological, pharmacological, and …
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Barcoded Transposon Directed Insertion-site Sequencing (TraDIS); a tool to improve our understanding of the functional genomics of Streptococcus equi subsp. equi
… medium in vitro, 73.4 percent of genes being non-essential, with the remainder either not defined or of an ambiguous assignment. Comparative analysis revealed that more than 83 percent of the essential gene set of S. equi was concordant with the essential genomes of S. pyogenes and S. …