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Showing 1 to 20 of 54 for “"Non-heme"”.
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Metal complexes of non-heme ligands: biological applications
… trypsin, chymotrypsin and 20S proteasome) by non–heme iron complexes, and glutathionylation of non–heme cobalt complexes mimicking the N5 coordination environment like that of biologically important cofactor cobalamin or B<sub>12</sub> (Cbl) are reported. Different non–heme ligand sets or …
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Oxyanion reduction in a non-heme iron system
The secondary coordination sphere of metalloenzymes is implicated in controlling nuclearity, enhancing substrate selectivity, and stabilizing reactive intermediates, and is thus essential in promoting the reactivity of the metal center in the active site. Inspired by the small molecule activation …
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Small molecule activation and reduction using non-heme iron complexes
In Nature, metalloenzymes are responsible for carrying out a vast array of different reactions. The secondary coordination sphere of these play an intricate role in controlling nuclearity, enhancing substrate selectivity, stabilizing reactive intermediates, and controlling the redox potential of …
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Oxidation of substrates tethered to N-donor ligands for modeling non-heme diiron enzyme active sites
… Diiron Sites of Dioxygen-Dependent Non-Heme Enzymes Carboxylate-bridged diiron centers are employed in a variety of biological systems to activate dioxygen for substrate oxidation, and small molecule models have been synthesized to mimic this chemistry outside of the natural systems. …
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Modeling the active sites of non-heme diiron metalloproteins with sterically hindered carboxylates and syn N-Donor ligands
… Modeling the Active Sites of Carboxylate-Bridged Non-Heme Diiron Enzymes Carboxylate-bridged non-heme diiron enzymes activate dioxygen to perform a variety of biological functions. Synthetic model compounds have been prepared to gain insight into the intricacies of dioxygen activation in these …
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Advances in non-heme diiron modeling chemistry : developing functional protein mimics through ligand design and understanding dioxygen activation
… employed to prepare biomimetic complexes of non-heme diiron protein active sites, highlighting the accomplishments of the past as well as the challenges for the future. Studies of various model systems have led to a more profound understanding of the fundamental properties of …
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Two versatile cofactors, flavin adenine dinucleotide and non-heme iron, involved in DNA repair and natural product halogenation
… cofactors, flavin adenine dinucleotide (FAD) and non-heme iron, together with molecular oxygen as an oxidizing agent, perform a wide array of reactions. Hydroxylation in DNA repair is one example. AidB is an adaptive response protein that is up-regulated in the presence of alkylating agents. AidB …
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Non-heme iron C-H oxidation: tolerance of nitrogen-containing motifs with application to amino-acid and peptide oxidation
Direct oxidation of C-H bonds using non-heme iron catalysis has proven to be a highly useful transformation since its development in recent years. The ability to directly install oxygen into a hydrocarbon framework negates the need for pre-oxidized materials, and allows for quick and efficient …
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I. Biomimetic oxidations using non-heme iron catalysis. II. Palladium- and hypervalent iodine-catalyzed tandem wacker-dehydrogenation of terminal olefins
ABSTRACT I. BIOMIMETIC OXIDATIONS USING NON-HEME IRON CATALYSIS Nature’s oxidation catalysts promote a remarkable variety of highly selective oxidation reactions of alkanes, olefins, and arenes. Inspired by this diversity of reactivity, the chemical community has long sought to replicate enzymatic …
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Use of sterically hindered carboxylate ligands to model structural and functional features of dioxygen-activating centers in non-heme diiron enzymes
… I. Modeling Dioxygen-Activating Centers in Non-Heme Diiron Enzymes: Carboxylate Shifts in Diiron(II) Complexes Supported by Sterically Hindered Carboxylate Ligands General synthetic routes are described for a series of diiron(II) complexes supported by sterically demanding carboxylate …
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Reactions of dioxygen and nitric oxide with iron(II) compounds : models for chemistry occuring in the active sites of non-heme iron enzymes
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1995.
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The Effect of Soy Products in The Diet on Retention of Non-Heme Iron From Radiolabeled Test Meals Fed to Marginally Iron-Deficient Young Rats
Diets based either on casein or soy products and containing about 25 ppm iron were fed to weanling rats for 13 days. Rats were fasted overnight and fed a ('59)Fe-radiolabeled casein test meal the morning of day 14. On day 21 less ('59)Fe was retained by rats fed various diets based on selected soy …
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Crystallographic studies on enzymatic halogenation of natural products
… the flavin-dependent halogenases and the non-heme iron dependent halogenases. Structures of the flavin-dependent tryptophan 7-halogenase RebH from Lechevalieria aerocolonigenes, involved in rebeccamycin biosynthesis, were solved by molecular replacement. These structures show distant …
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Computational Investigation of the Catalytic and Structural Roles of Metals in Metalloenzymes
… in governing selective halogenation catalyzed by non-heme iron halogenases. Demonstrating the utility of this protocol, our simulations provide essential insights on the interplay between strategic substrate positioning, active-site configurational isomerization, and protein dynamics in …
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Computational study on the selectivity of iron-containing hydroxylase
… functionalization catalyzed by Iron-containing heme and nonheme were studied, using cytochrome P450 and PtlH as examples. In this work, the C-H activation in the hydroxylation reaction of a model substrate artemisinin catalyzed by three selective P450BM3 variants was studied by combined …
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Engineering Myoglobin Into Both a Structural and Functional Model of Nitric Oxide Reductase
… that the identity of the metal in analogous non-heme metal binding sites of HCO (i.e., CuB) and NOR (i.e., FeB) can tune NO activity. In summary, FeBMb is both a structural and functional model of NOR. (Abstract shortened by UMI.).
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Experimental and theoretical studies of the photosystem II reaction center: Implications for bicarbonate binding and function
… near the putative bicarbonate binding sites, the non-heme iron and the Q$\sb{\rm B}$ binding niche, were mutated in a unicellular green alga Chlamydomonas reinhardtii. The effects of mutations on bicarbonate binding and on other aspects of PSII photochemistry were investigated.
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Dioxygen activation and substrate hydroxylation by the hydroxylase component of toluene/O-xylene monooxygenase from pseudomonas sporium OX1
Non-heme carboxylate-bridged diiron centers in the hydroxylase components of the bacterial multicomponent monooxygenases activate dioxygen at structurally homologous active sites. Catalysis requires the management of four substrates: electrons, protons, dioxygen, and hydrocarbons. Protein component …
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Dynamics of blue copper proteins
Studies of small molecules binding to heme proteins have yielded a large amount of information about protein dynamics and conformational substates (CS) in proteins. However, heme proteins are very similar in their active site structures, and relatively little work exists on non-heme proteins which …
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C—H oxidation reactions: development and application
… as well as applications of a biomimetic non-heme iron catalyst towards generating diverse oxidation products and exploring biological pathways. Linear allylic amines are a common motif found in many organic molecules; however, their synthesis involves a lengthy, multi-step sequence that …
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