Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 184 for “"Non-coding RNAs"”.
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Functional large non-coding RNAs in mammals
… vast and diverse functions. These functional RNAs include the ribosomal, transfer, and splicing-associated RNAs along with a cast of tiny RNAs, including microRNAs and other families. In addition to these classic examples, there were a handful of known functional large ncRNAs that play …
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Novel Algorithms for Structural Alignment of Non-coding RNAs
Non-coding RNAs are biologically important molecules, with a variety of catalytic and regulatory activities mediated by their secondary and tertiary structures. Base-pairing interactions, particularly at the secondary structure level, are an important tool for identifying and studying these …
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Landscape of Ecdna-Borne Non-Coding Rnas In Glioblastoma
… oncogene transcription can occur on a form of non-chromosome DNAs that is often amplified to tens or hundreds of copies, and that can exist in more than half of cancer types. This type of genetic material was termed extrachromosomal DNA (ecDNA). ecDNA appears to be epigenetically highly …
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Genome wide search for pseudo knotted non-coding RNAs
Non-coding RNAs (ncRNAs) are the functional RNA molecules that are involved in many biological processes including gene regulation, chromosome replication and RNA modification. Searching genomes using computational methods has become an important asset for prediction and annotation of ncRNAs. To …
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Role of long non-coding RNAs in breast cancer progression
… that the majority of genome is transcribed into non-protein coding RNAs (ncRNAs), including thousands of long ncRNAs (lncRNAs). At present, we do not know the biological function of majority of these lncRNAs. MALAT1 (metastasis associated lung adenocarcinoma transcript1) is a lncRNA which its …
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Characterising functions of long non-coding RNAs in Drosophila embryogenesis
… regulation with the discoveries of functional non-coding ribonucleic acids (RNAs). In recent years, the number of studies in the field of long non-coding RNA (lncRNA) biology has increased dramatically. Transcriptomic analyses of the eukaryotic genome revealed that the genome is pervasively …
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Modulation of lineage-specific cell differentiation by long non-coding RNAs
Mammalian genomes comprise thousands of non-protein-coding genes. These can produce small non-coding RNAs (such as rRNAs and tRNAs), as well as long non-coding RNAs (lncRNAs), which are >200nt and resemble mRNAs in their biogenesis. Although the functions of the vast majority of lncRNAs remain …
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Caracterització estructural i funcional de long non-coding RNAs (lncRNAs) en nematodes
… l'expressió genètica i que tots els gens dels lncRNAs amb els quals interaccionen es troben en coordenades allunyades.
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Regulation of Gene Expression by Non-coding RNAs in Arabidopsis and Brachypodium
… and the resulting indispensable molecules, noncoding RNAs (ncRNAs). A significant effort has been made in determining the biological relevance of ncRNAs, including the small RNAs (smRNAs) and long ncRNAs (lncRNAs). Studies have shown that ncRNAs can have very important regulatory functions …
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Structure-based realignment of non-coding RNAs in multiple whole genome alignments
… A major application is the de novo prediction of non-coding RNAs (ncRNAs) from structural conservation visible in the alignment. However, current methods for constructing genome alignments do so by explicitly optimizing for sequence similarity but not structural similarity. Therefore, de novo …
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Non-Coding Rnas Identify The Intrinsic Molecular Subtypes of Muscle-Invasive Bladder Cancer
<p><strong>NON-CODING RNAS IDENTIFY THE INTRINSIC MOLECULAR SUBTYPES OF MUSCLE-INVASIVE BLADDER CANCER</strong></p> <p>Andrea Elizabeth Ochoa, B.S.</p> <p>Advisory Professors: David J. McConkey, Ph.D. and Joya Chandra, Ph.D.</p> <p>There has been a recent explosion of genomics data in …
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Identifying and Characterizing Non-Coding RNAs in the Dinoflagellate <i>Karenia brevis</i>
… confirmed the expression of targeted anti-sense RNAs (asRNAs) and characterized their sequences. We have developed a model in which the expression of asRNAs leads to the formation of double-stranded RNAs (dsRNA). I have immunofluorescence data to support the presence of dsRNA in K. brevis cells. …
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Identification and characterisation of non-coding RNAs involved in ductal carcinoma in situ
… invasive DCIS. To do this, I identified non-coding ribonucleic acids (ncRNAs) that are involved in DCIS and aimed to discover their molecular functions. Through target-capture RNA sequencing, I identified 181 ncRNAs overexpressed in high-grade DCIS cell lines (ETCC-006 and ETCC-010), …
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Investigating the Role of Viral Long Non-Coding RNAs During Human Cytomegalovirus Latency
… severe disease in the immunosuppressed or immunonaïve, including transplant recipients and people living with AIDS. Although there are several drugs approved for the treatment of HCMV, none of them clear the virus from the host as they do not target latent infection. Consequently, reactivation …
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Characterization of Non-Coding RNAs in Regulating Thymic Epithelial Cell Responses to Pathophysiological Stress
… cells initiate the involutionary response. MicroRNAs (miRs) are small non-coding RNAs ~18-22 nucleotides in length that maintain cellular homeostasis and regulate stress responses. Previous work in the laboratory identified several microRNAs involved in regulating thymocyte responses to stress. …
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In silico prediction of non-coding RNAs using supervised learning and feature ranking methods
… novel method, RNAMultifold, for development of a non-coding RNA (ncRNA) classification model based on features derived from folding the consensus sequence of multiple sequence alignments using different folding programs: RNAalifold, CentroidFold, and RSpredict. The method ranks these folding …
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