Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 521 for “"Non-coding"”.
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Non-Coding Genomics of Methanocaldococcus Jannaschii: A Survey of Promoters, Non-Coding RNA Genes, and Repetitive DNA Elements
Non-protein-coding sequences of a genome carry out various tasks which contribute to the functionality of the genome as an information carrier. They are essential genomic components and are operative in genetic information remission, transfer, and processing---key processes where the three domains …
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Evolutionary Fitness of Non-Coding Genetic Elements
… the genome. While typically neutral in protein-coding genes, such variations can result in the loss of function of a protein-coding gene or produce a novel protein-coding gene. A former protein-coding gene can behave as a reservoir for novel protein-coding genes or variants of known proteins. …
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Bioinformatics analyses of non-coding genomic elements
"Mammalian genomes consist primarily of non-coding sequences (Kellis et al. 2014). Originally castigated as ""junk DNA"", many non-coding regions have now been characterized as having functional roles, or have been determined to be the causal agent for diseases. Additionally, sequences that are …
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Functional large non-coding RNAs in mammals
… units that do not overlap any known proteincoding genes. Using this approach we identified -3,500 transcriptional units in the human and mouse genomes that produce multi-exonic RNAs that lack any coding potential. We termed these large intergenic non-coding RNAs (lincRNAs). Importantly, …
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Pan-Cancer Analysis of Non-Coding Driver Mutations
… of drivers have been found in the ~2% protein-coding regions. Despite an intensive search for non-coding cancer drivers, however, only a few have been discovered to date. Here I describe DriverPower, a software package that uses mutational burden and functional impact evidence to identify …
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Role of long non-coding RNA in atherosclerosis
… needed to address this global epidemic. Long noncoding RNAs (lncRNAs) are an emergent class of molecules with diverse functional roles, widely expressed in human physiology and disease. Although some lncRNAs have already been identified in cardiovascular disease, their potential as novel …
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Dissecting the Functional Impacts of Non-Coding Genetic Variation
… of the variants are located outside of protein-coding regions, and determining the effects of such non-coding variants remains difficult. In this dissertation, I evaluate the hypothesis that such non-coding variants contribute to human traits and diseases by altering the regulation of genes …
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FUNCTIONAL ROLE OF NON-CODING REGULATORY VARIANTS IN NEUROBLASTOMA
Emerging evidence suggests that non-coding somatic variants in cancer can contribute to disease, mainly by residing in functional regulatory regions and ultimately affecting gene expression networks. However, their interpretation is challenging. In our recent work, whole-genome sequencing (WGS) …
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Novel Algorithms for Structural Alignment of Non-coding RNAs
Non-coding RNAs are biologically important molecules, with a variety of catalytic and regulatory activities mediated by their secondary and tertiary structures. Base-pairing interactions, particularly at the secondary structure level, are an important tool for identifying and studying these …
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Landscape of Ecdna-Borne Non-Coding Rnas In Glioblastoma
… oncogene transcription can occur on a form of non-chromosome DNAs that is often amplified to tens or hundreds of copies, and that can exist in more than half of cancer types. This type of genetic material was termed extrachromosomal DNA (ecDNA). ecDNA appears to be epigenetically highly …
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Genome wide search for pseudo knotted non-coding RNAs
Non-coding RNAs (ncRNAs) are the functional RNA molecules that are involved in many biological processes including gene regulation, chromosome replication and RNA modification. Searching genomes using computational methods has become an important asset for prediction and annotation of ncRNAs. To …
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Pathogenicity and selective constraint in the non-coding genome
… to examine the forces of selection operating on non-coding elements genome-wide. Finally, I conducted a pilot experiment to assay >50,000 different non-coding variants across more than 700 different non-coding elements, including variants observed in patients with developmental disorders in a …
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Role of long non-coding RNAs in breast cancer progression
… that the majority of genome is transcribed into non-protein coding RNAs (ncRNAs), including thousands of long ncRNAs (lncRNAs). At present, we do not know the biological function of majority of these lncRNAs. MALAT1 (metastasis associated lung adenocarcinoma transcript1) is a lncRNA which its …
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Characterising functions of long non-coding RNAs in Drosophila embryogenesis
… regulation with the discoveries of functional non-coding ribonucleic acids (RNAs). In recent years, the number of studies in the field of long non-coding RNA (lncRNA) biology has increased dramatically. Transcriptomic analyses of the eukaryotic genome revealed that the genome is pervasively …
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Non-Coding RNA Features Critical to the Replication of HIV-1
… for viral replication, we conducted a global synonymous mutagenesis experiment. Sixteen mutant proviruses containing clusters of ~50 to ~200 synonymous mutations covering nearly the entire HIV-1 protein coding sequence were designed and synthesized. Analyses of these mutant viruses resulted in …
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Investigation of key non-coding and coding genes in cutaneous melanomagenesis
Cutaneous melanoma is associated with significant morbidity and mortality representing the most significant cutaneous malignancy. As it is known that early diagnosis and treatment are the most efficient approaches to cure cutaneous melanoma, an improved understanding of the molecular pathogenesis …
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Development of High-Throughput Methods for Screening the Non-coding Genome
… these studies demonstrate novel methods for decoding regulatory networks and furthering our ability to assign function to regulatory sequence influencing disease.</p>
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Probabilistic Model-Based Approach to Evolutionary Analysis of Non-Coding Sequences
Non-coding sequences, constituting a large fraction of genomic DNA, are of great importance because (i) they harbor functional elements that are involved in the regulation of gene expression and (ii) they are essential for the study of genome structure and evolution. The availability of genome …
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