Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Non-canonical translation"”.
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Human non-canonical translation initiation factors EIF4E2 and EIF4E3
The family of eukaryotic translation initiation factors 4E (EIF4E) comprises of a group of proteins that recognise the 7-methylguanosine cap at the 5' mRNA end to initiate translation. In humans, there are three isoforms, EIF4E1, EIF4E2 and EIF4E3. EIF4E1 participates in global translation and is …
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Analysis of the Role of EIF5A in Mammalian Translation
… factor 5A (EIF5A) as novel regulator of MYC translation. eIF5A is a highly conserved translation factor that has been demonstrated to relieve ribosome pauses during translation elongation at 'difficult to translate' peptide sequences in yeast and bacteria. We observed that eIF5A regulates …
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Eukaryotic Initiation Factor 3 Interactions with Structural Elements of Barley Yellow Dwarf Virus Untranslated Regions Reveal Details of a New Cap-Independent Translation Initiation Model
… tail, features that are required for canonical mRNA translation. BYDV’s non-canonical translation relies on RNA structures in the 5′ and 3′ untranslated regions (UTRs) to recruit eukaryotic initiation factors (eIFs) and ribosomes. BYDV’s 3′ translation enhancer (BTE) is a cruciform …
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An E. coli small RNA inhibits translation initiation from a distance
In bacterial systems, small RNA (sRNA)-dependent translational repression is commonly carried out via sRNA-mRNA base pairing interactions near the Shine-Dalgarno (SD) region. In this so-called “canonical” mechanism, the sRNA is the direct regulator; it competes with the initiating ribosomes while …
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Translational regulation in aggressive B-cell lymphomas
… precision. Here I investigate the mechanisms of translational regulation contributing to lymphoma development. Firstly, I introduce RiboStream, an automated bioinformatic pipeline designed to streamline processing of Ribo-Seq datasets while maintaining transparency and reproducibility of the …
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Interrogating annotated protein coding regions for hitherto undetected translation
… genomics analysis in order to discover non-AUG initiated proteoforms derived via alternative translation start sites that are in-frame with annotated starts. Production of such non-AUG proteoforms can be split into two scenarios. First, some nonAUG proteoforms are generated as …
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Translation-Mediated Stress Responses: Mining of Ribosome Profiling Data
… This approach allows detection of differential translation activity, annotation of novel protein coding sequences and variants, identification of ribosome pause sites and estimates of de novo protein synthesis. As with other sequencing based methodologies, a major challenge of ribosome profiling …