Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Non-canonical role"”.
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Revealing a Non-canonical Role of Anti-apoptotic MCL-1 in Early Embryonic Development
… Our previous studies revealed an unrecognized role of MCL-1 in promoting mitochondrial physiology, which is independent of its classical anti-apoptotic function and requires being imported into the mitochondrial matrix. In order to understand the role of MCL-1 in early embryonic development, we …
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A Non-Canonical Role for a Small Nucleolar RNA in Ribosome Biogenesis and Cellular Senescence
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Identification of the molecular pathways that mediate cytokine induced immunopathology of the gut epithelium
Although the phenomenon of synergistic cell death induced by the combination of IFN-γ and TNF-α has been known for more than 30 years, the underlying mechanisms are still not clear. The main aim of my PhD was to identify the mechanisms which are required for the killing of human intestinal …
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Leucyl-tRNA synthetase: dynamic subcellular relocalization and drug resistance mechanism
… targets. A new class of antimicrobial benzoxaborole compounds was identified as a potent inhibitor of leucyl-tRNA synthetase (LeuRS) and therefore of protein synthesis. AN2690 (5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole) blocks fungal cytoplasmic LeuRS by trapping tRNALeu in the editing …
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Mechanistic Insights into the Stimulation of Dot1L-Mediated Methylation of Histone H3 by Semisynthetically Ubiquitylated Histone H2b
… modification of histones plays an integral role in regulation of chromatin-templated processes through modulation of chromatin structure and function. One such modification, ubiquitylation of histone H2B on lysine 120 (uH2B), has been correlated with enhanced methylation of lysine 79 (K79) …
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Combination of Compounds A2CE and C18 for Cochlear Hair Cell Regeneration in Adult Mice
… of p27kip1, which has been shown to have a non-canonical role in suppressing a cofactor for Atoh1, which is an upstream of POU4F3 and is an important developmental gene in hair cell development. We gave transtympanic injections of our drug cocktails to either FVB or Sox2 CreER; Tdtomato mice …