Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Non-canonical Wnt Signaling"”.
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Cigarette Smoke Exposure in Drosophila Reveals Wnt-Mediated Remodeling of Airway Structure and Systemic Physiology
… evidence implicates dysregulation of the Wnt signaling pathway in COPD pathogenesis, yet the distinct roles of canonical and non-canonical Wnt signaling in smoke-induced airway injury remain incompletely understood. In this study, a chronic cigarette smoke–exposed Drosophila melanogaster …
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Characterization of Dishevelled Associated Activator of Morphogenesis 2 (Daam2) in Wnt Signaling During Early Embryonic Development
The Wnt signaling pathway is highly conserved in metazoan animals. Wnt signaling regulates an array of cellular processes that include motility, polarity, cell fate determination, primary axis formation and organogenesis and recently have been implicated in stem cell renewal. Deregulated Wnt …
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Control of proliferation in human mesenchymal stem cells by Secreted Frizzled Related Protein 1
… would like to confirm the relationship between Wnt signaling and proliferation of hMSCs. When checked mRNA expression of various genes that were related to Wnt signaling, most of genes were decreased gradually as follow passages, except Wnt11. Especially, gene expression of sFRP1, an antagonist …
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Wnt Secretion Proteins Modulate RANKL-Induced Expression of Aire in Thymic Epithelial Cells
… In the thymus, TECs differentially express Wnt proteins, which activate canonical and non-canonical Wnt signaling pathways. Wnt signaling is thought to regulate cell survival, proliferation, and development although the direct molecular mechanisms in TECs have yet to be elucidated. The …
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FUNCTIONAL CHARACTERIZATION OF DENND5A/RAB6IP1 IN EARLY EMBRYONIC DEVELOPMENT
… two hybrid screen. Daam1 is a key player in non-canonical Wnt signaling and regulates vertebrate gastrulation and neural tube closure. I confirmed that Daam1 can physically bind to Dennd5a in immunoprecipitation assays using epitope tagged constructs. In the cellular level experiment, Dennd5a …
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Discovery and Characterization of Novel Chemical Inhibitors of Wnt Ligand Production with Implications for Anti-Cancer Therapy
The widespread and indispensable nature of Wnt morphogens during early development has long been a focal point of embryogenesis research. More recently, pathway activation has been uncovered in adult stem cell niches and cancers arising from associated tissues. Consequently, interest has shifted …
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Structural Basis for Dishevelled-2 Association to the Plasma Membrane
The Wingless (Wnt) signaling pathway is one of the critical developmental pathways for control of cell differentiation, proliferation, and cell growth. The DEP domain, located on the C-terminus of Dishevelled (Dvl), plays a role in cytoplasm-membrane association, which branches the canonical and …
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The Study of Wnt Signaling Effector POP-1/TCF in C. Elegans Early Embryos
In C. elegans embryos, the combined Wnt/MAPK pathway polarizes the founder cell of mesendoderm, EMS blastomere, such that EMS produces two daughters with distinct developmental fates. The posterior daughter E, whose fate is specified by Wnt/MAPK, generates intestinal tissues (endoderm), whereas the …
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The roles of T and Tbx6 during gastrulation and determination of left/right asymmetry
… not expressed in TWis mutants and that the Notch signaling pathway, a pathway necessary for expression of left/right specific genes, is severely perturbed. We find, through the use of confocal and scanning electron microscopy, that TWis homozygous mutants have severe node morphological defects. …
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CAMK-II: AN INTEGRAL PROTEIN IN CELL MIGRATION
… and postembryonic migratory events. The non-canonical Wnt pathway has been identified as an evolutionarily conserved signaling pathway, regulating C&E cell movements during vertebrate gastrulation. With the absence of the non-canonical Wnts (ncWnts), Wnt5 and Wnt11, during zebrafish …
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New Insights into the Regulatory Network Controlling Neuroblast Migration in C. elegans
… The initial migrations are controlled via a Wnt-independent pathway. Both QR and QL are born between the hypodermal seam cells V4 and V5. Between 3 hours to 4.5 hours post hatching QR begins migrating anteriorly on top of V4. At the same time QL migrates posteriorly on top of V5. This process …