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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 32 for “"Non-alcoholic Steatohepatitis"”.

  1. The role of adipose tissue in the pathogenesis of non-alcoholic steatohepatitis

    Dagpo, Tenzin2015

    … metabolic disorders, type 2 diabetes (T2D) and non-alcoholic steatohepatitis (NASH) are rapidly increasing worldwide in parallel with increasing obesity rates. These obesity-related conditions are also associated with adipose tissue inflammation and dysfunction. In response to overfeeding, some …

    aus-cath Repository record

  2. The role of adipose tissue in the pathogenesis of non-alcoholic steatohepatitis

    Dagpo, Tenzin2015

    … metabolic disorders, type 2 diabetes (T2D) and non-alcoholic steatohepatitis (NASH) are rapidly increasing worldwide in parallel with increasing obesity rates. These obesity-related conditions are also associated with adipose tissue inflammation and dysfunction. In response to overfeeding, some …

    anu Repository record

  3. The role of "non-alcoholic steatohepatitis (NASH)" in methotrexate induced liver injury

    Langman, GeraldDivision of Anatomical Pathology2001

    … for psoriasis. The histological features are nonspecific and may resemble those of nonalcoholic steatohepatitis (NASH). Moreover most of the risk factors of MTX induced liver injury are also associated with NASH. In this study serial liver biopsies of 24 psoriatic patients on lOng-term MTX …

    cape-town Repository record

  4. Non-alcoholic Steatohepatitis (NASH) Models for Preclinical Testing of Cell Death Inhibitors In Vitro

    Jones, Shelley

    gmu

  5. DEVELOPMENT OF IN VITRO NON-ALCOHOLIC STEATOHEPATITIS (NASH) MODEL FOR DRUG TESTING AND PATHOGENESIS STUDIES

    ZHAO ZIXUAN2023

    Non-alcoholic steatohepatitis (NASH) is a severe chronic fatty liver disease that currently has no effective intervention. Hepatocellular ballooning is one of the key features of NASH diagnosis. Due to their scarcity, it is difficult to study in vivo and isolate for in vitro investigations. How …

    nus Repository record

  6. Diversified use of Non-invasive Biomarkers in Study Protocol and Screen failure in Non-Alcoholic Steatohepatitis (NASH)

    Masaye, Nikita P.2023

    This study examines how non-invasive biomarkers of NASH are introduced into the study protocol and whether this has an impact on screen failure. The study will investigate the use of non-invasive biomarkers in the design of study protocols for NASH drug trials and will also examine if screening …

    tdl Repository record

  7. Effect of Delta-Tocotrienol and Grape Seed Polyphenol on Lipid Profile in C57BL/6J Mice with a Western-Like Diet-Included Non-Alcoholic Steatohepatitis

    Mendez, MelissaTexas Woman's University2013

    Non-alcoholic steatohepatitis (NASH), the second phase in liver disease, occurs when adults consume high calorie, high fat diets. Fat accumulated in the liver causes inflammation and irreversible hardening. Grape seed polyphenol (GSP) and d-tocotrienol (d-T3) may have benefits in reducing NASH. We …

    twu Repository record

  8. Modulation of Obesity and its Sequelae by Microbiome/Immune System Interactions

    Harley, Isaac T.University of Cincinnati2012

    … progression of a particular sequelum of obesity, non-alcoholic steatohepatitis. Our data indicate that SFB provides modest protection from the development and maintenance of obesity, but this was mostly evident only in the setting of severe monogenic obesity. Colonization with SFB also exacerbated …

    ohiolink Repository record

  9. Using Telemedicine To Optimize The Delivery Of Care In Patients With Liver Disease

    Ramirez, Samantha

    … globally. Among the spectrum of liver diseases, non-alcoholic steatohepatitis (NASH) is the most common cause of cirrhosis and one of the top reasons for a liver transplant. Patients with NASH end up with hepatic decompensation and liver-related complications such as malnutrition, sarcopenia, …

    yale Repository record

  10. Role of Ceramidase in Regulating Hepatic Lipid Metabolism and Whole Body Insulin Sensitivity

    Xia, Jonathan Y.2019

    … with the rise in obesity, the prevalence of non-alcoholic fatty liver disease (NAFLD), a newly emerging obesity-related disorder, has also been rising steadily. NAFLD is a chronic liver disease that ranges histologically from simple steatosis in its mildest form to non-alcoholic …

    utswmed Repository record

  11. The db mouse as a model for steatohepatitis

    Sutherland, Jason RobertDivision of Anatomical Pathology2006

    … of the liver to an inflammatory condition, steatohepatitis, which may lead onto cirrhosis. Although not associated with alcohol consumption, non-alcoholic steatohepatitis (NASH) has strong associations with obesity, diabetes and dyslipidaemia. Overlapping pathological mechanisms may be …

    cape-town Repository record

  12. The Effects of Chromatin Remodeling and Pseudokinase Activity on Liver Pathophysiology

    Moore, Austin Bradley2023

    … lead to chronic liver diseases such as non-alcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma. Although these processes are complex and not completely understood, specific genetic and epigenetic factors that drive aspects of this pathophysiology can shed further light on …

    utswmed Repository record

  13. Molecular and systems-level analyses reveal the emerging role of non-coding RNAs in liver diseases

    Wang, HaoQueen's University Belfast2022

    … body. Thus, the liver is prone to many diseases. Non-alcoholic fatty liver disease (NAFLD), the most common liver disease, is an umbrella term for a range of conditions compromising hepatic steatosis, non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis without alcohol consumption, which …

    qu-belfast Repository record

  14. Surface Modifications of Iron Oxide Nanoparticles for Magnetic Imaging and Diagnosis

    Zhang, JuanyeMassachusetts Institute of Technology2022

    … of colloidal iron oxide nanoparticles as non-toxic MRI contrast agents for diagnosis. Novel single-nanometer iron oxide (SNIO) nanoparticles exhibited contrast enhancement in T1-weighted MRI superior than commercially used gadolinium-based contrast agents, with unprecedentedly fast and …

    mit Repository record

  15. Elucidating the role of SRSF1, a prototypical splicing factor, in liver physiology

    Arif, WaqarUniversity of Illinois at Urbana-Champaign2021

    … and exhibited pathology like the human disease Non-alcoholic steatohepatitis. Specifically, loss of SRSF1 results in immediate cell death and triggers a regenerative response in the liver. While SRSF1 was initially discovered as a splicing factor, studies since its discovery has revealed it …

    uiuc Repository record

  16. Engineering in vitro models of non-alcoholic fatty liver disease

    Davidson, Matthew David, author, Khetani, Salman R., advisor, Chicco, Adam J., committee member, Donahue, Seth W., committee member, Kota, Arun K., committee memberColorado State University. Libraries2017

    … rates throughout the world. Consequentially, non-alcoholic fatty liver disease (NAFLD), which is highly correlated with obesity, rates are also increasing with greater than 30% of the US population currently diagnosed. NAFLD starts as a benign state of fat accumulation within liver hepatocytes …

    colostate Repository record

  17. Investigating the role of transcription factor Nrf2 in the pathogenesis of NAFLD

    Wood, K. L.University of Dundee2017

    The pathogenesis of non-alcoholic steatohepatitis (NASH) is thought to occur through interacting mechanisms of cellular stress. Lipids accumulate within hepatocytes, making cells more susceptible to insult and less able to respond to challenges, leading to progression from simple steatosis to …

    dundee Repository record

  18. The unfolded protein response regulates hepatocellular injury during the pathogenesis of nonalcoholic steatohepatitis

    Willy, Jeffrey Allen2016

    Non-alcoholic steatohepatitis (NASH), which is characterized by the induction of hepatocellular death and inflammation, is associated with the activation of cellular stress pathways such as the Unfolded Protein Response (UPR), an adaptive response to disruptions in endoplasmic reticulum (ER) …

    iupui Repository record

  19. The Role and Regulation of Caspase-2 in Lipoapoptosis

    Lindblom, Kelly2015

    <p>Non-alcoholic fatty liver disease (NAFLD) is now the most common liver disorder in Western countries. NAFLD is characterized by hepatic steatosis, or an intracellular accumulation of lipids in hepatocytes. An excess of intracellular lipids can cause toxicity, leading to hepatocyte cell death and …

    duke Repository record

  20. Hepatoprotective properties of Gentiana SPP: Against non-alcoholic fatty liver disease (NAFLD)

    Boateng, A.University of Westminster2018

    Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease characterised by the accumulation of fat in the liver. It is estimated that 33 % of the UK population have NAFLD with 2-5 % progressing to non-alcoholic steatohepatitis (NASH). Due to a lack of an outright therapy for NAFLD, treatment …

    westminster Repository record

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