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Showing 1 to 20 of 74 for “"Non-alcoholic Fatty Liver Disease"”.
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Personalised Medicine for Non-Alcoholic Fatty Liver Disease
Non-Alcoholic Fatty Liver Disease (NAFLD) is a chronic and dangerous condition which has grown in prevalence over recent decades due to increasing rates of obesity, affecting roughly a quarter of adults globally. This thesis develops a useable NAFLD definition which can be applied to large …
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Non-invasive diagnosis of non-alcoholic fatty liver disease.
Non-alcoholic fatty liver disease (NAFLD) has become one of the top concerns for the practising hepato-gastroenterologist due to the obesity epidemic and its potential to progress to an advanced liver disease that significantly impacts on overall and liver-related mortality. Due to the rapidly …
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Engineering in vitro models of non-alcoholic fatty liver disease
… rates throughout the world. Consequentially, non-alcoholic fatty liver disease (NAFLD), which is highly correlated with obesity, rates are also increasing with greater than 30% of the US population currently diagnosed. NAFLD starts as a benign state of fat accumulation within liver hepatocytes …
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Hepatoprotective properties of Gentiana SPP: Against non-alcoholic fatty liver disease (NAFLD)
Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease characterised by the accumulation of fat in the liver. It is estimated that 33 % of the UK population have NAFLD with 2-5 % progressing to non-alcoholic steatohepatitis (NASH). Due to a lack of an outright therapy for NAFLD, treatment …
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Effect of the ligands of thyroid hormone receptor on non-alcoholic fatty liver disease
The term non-alcoholic fatty liver disease (NAFLD) has been used as a general name for conditions ranging from simple steatosis to steatohepatitis, advanced fibrosis and cirrhosis. End-stage NAFLD cirrhosis carries a substantial risk for early hepatocellular carcinoma development. Therefore, there …
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Effects of vitamin D on pro-inflammatory cytokines associated with Non-alcoholic fatty liver disease
ABSTRACT|Non- alcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in the United States, affecting approximately one-third of the population. The prevalence of NAFLD increases to 90% in morbidly obese individuals. Many studies have shown a negative association between …
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PKC-δ and Insulin Resistance in Non-Alcoholic Fatty Liver Disease: Effect of Vitamin D
ABSTRACT|Nonalcoholic fatty liver disease (NAFLD) due to excess ectopic fat deposit in the liver of nonalcoholic is a broad spectrum of liver diseases encompassing simple liver steatosis to more complicated and morbid steatohepatitis (NASH) that can lead to cirrhosis and even to hepatocellular …
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A systems biology approach to the pathogenesis and progression of Non-Alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease (NAFLD) refers to a spectrum of diseases ranging from simple steatosis (isolated hepatic fat accumulation) to steatohepatitis (NASH; hepatic fat accumulation with lipotoxicity, hepatic cell damage and inflammation), eventually progressing to fibrosis, cirrhosis and …
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Investigation of Microbiome Metabolites and Mitochondrial Function in a model of Non-Alcoholic Fatty Liver Disease
… produced by gut bacteria have been linked to disease including non-alcoholic fatty liver disease (NAFLD). Trimethylamine N-oxide (TMAO) and phenylacetic acid (PAA) are microbiome-derived metabolites that have been associated with early onset of NAFLD. Hypothesising that these metabolites …
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INVESTIGATING THE ROLE OF LIPID DROPLETS AS INTRACELLULAR MECHANICAL STRESSORS IN NON-ALCOHOLIC FATTY LIVER DISEASE
… external mechanical stress have been linked to disease and cancer development in multiple tissues, including the liver, where cirrhosis (which increases stiffness markedly) is the major risk factor for hepatocellular carcinoma (HCC). Stiffness is correlated with cancer development and patient …
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Non-Alcoholic Fatty Liver Disease: Investigating the Impact of Bariatric Care and the Role of Immune Function
Non-alcoholic fatty liver disease (NAFLD) ranges from simple steatosis (SS) to nonalcoholic steatohepatitis (NASH) and cirrhosis. It is one of the most common causes of chronic liver disease resulting from obesity. 74-98% of morbidly obese individuals have NAFLD at the time of bariatric surgery. …
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Biopsychosocial profile of non-alcoholic fatty liver disease (NAFLD) associated with liver transplantation and prevention of risk factors
En la presente Tesis Doctoral se han llevado a cabo un estudio teórico y cinco trabajos empíricos y pioneros que abordan principalmente distintos perfiles biopsicosociales de pacientes con EHGNA asociados, por un lado, a los distintos niveles de gravedad de la enfermedad hepática y, por otro lado, …
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INDUCED PLURIPOTENT STEM CELL DERIVED LIVER MODEL FOR THE STUDY OF PNPLA3-ASSOCIATED NON-ALCOHOLIC FATTY LIVER DISEASE
Non-alcoholic fatty liver disease (NAFLD) is now the leading cause of chronic liver disease in the developed world, afflicting approximately one in four adults globally. NAFLD is defined by the accumulation of fat within the liver which ranges in severity from simple steatosis to non-alcoholic …
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The (travel) times they are a changing : a computational framework for the diagnosis of non-alcoholic fatty liver disease (NAFLD)
We propose and validate a non-invasive method to diagnose Non-Alcoholic Fatty Liver Disease (NAFLD). The proposed method is based on two fundamental concepts: 1) the speed of sound in a fatty liver is lower than that in a healthy liver and 2) the quality of an ultrasound image is maximized when the …
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The role of microRNA-802 regulated by the nuclear receptor FXR-SHP cascade in obesity and non-alcoholic fatty liver disease
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-12-01
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Investigating the impact of non-alcoholic fatty liver disease on the pathogenesis and progression of heart failure with preserved ejection fraction
… risk factors is crucial; one such risk factor is non-alcoholic fatty liver disease (NAFLD). NAFLD has been shown to both predispose individuals to HFpEF and to increase HFpEF severity, independently of cardiovascular risk factors. However, whether the coexistence of these conditions is mediated …
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AAV9-mediated (Pro)renin Receptor Antagonism Reduces High Fat Diet Induced Hyperglycemia and Hepatic Steatosis in Mouse Model of Non-alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease (NAFLD) is one of the leading causes of liver diseases worldwide. It has been associated with impaired metabolism and increased accumulation of triglyceride (TG) in the liver, most of which is derived from exogenous sources including diet. Recent studies showed …
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THE ROLE OF HEPATIC ACAT2 AND MTP IN HEPATIC CHOLESTERYL ESTER AND TRIGLYCERIDE METABOLISM
Hepatic lipid metabolism plays a major role in non-alcoholic fatty liver disease (NAFLD) and atherosclerosis. The primary goal of this work was to delineate the role of the hepatic cholesterol-esterifying enzyme acyl-CoA:cholesterol acyltransferase 2 (ACAT2) in cholesterol balance and triglyceride …
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