Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 66 for “"Non-Human Primate"”.
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A non-human primate model of dorsolateral prefrontal cortex dysfunction in schizophrenia
Spatial working memory (SWM) impairment is a key cognitive symptom of schizophrenia, for which no effective treatment currently exists. In order to develop new treatments, we must better understand how these deficits arise from structural and functional changes within the neural circuits supporting …
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Optogenetic disruption of memory-drive, oculomotor behavior in the non-human primate
… millisecond-precise optical inactivation of the primate brain were invented. A red-shifted halorhodopsin (Jaws) and a novel large-volume tissue illuminator were used in two rhesus macaques to inactivate part of the FEF at different times during the memory-guided saccade task. Neuronal recordings …
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Influence of Antithymoglobulins on Ischemia/Reperfusion Injury in perfused non-human primate tissues
… brachiale Arterie mit Blutgruppen-kompatiblen Humanblut reperfundiert. Dem mit Krebs-Henseleit-Puffer auf einen Hämatokrit von 30% verdünntem Blut wurden ATGs 20 Minuten vor der Reperfusion zugefügt. Die Perfusion wurde mit Hilfe eines Perfusionssystems rezirkulierend durchgeführt. Die …
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Trophoblast specification and differentiation potential in early human and non-human primate embryogenesis
… which sustains fetal growth and development. Human embryo implantation and early trophoblast development have remained elusive due to the inaccessibility of early implantation stages. The conservation of trophoblast development between humans and non-human primates provides an exciting …
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Cerebral blood flow in the non-human primate : an in vivo model and drug interventions
… and dementia. Due to the similarities between humans and non-human primates with respect to their brains, both structurally and behaviourally, numerous studies have been conducted and several non-human primate models have been developed for physiological, pathological, pharmacological, and …
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Studies of immune biology of the common marmoset: a novel non-human primate transplant model.
… therapies, which must be validated in non-human primate models before clinical trials. The common marmoset is a small, New World primate which our group is developing as a novel transplant model. The scope of this thesis involves the development of methodology and characterisation of …
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A Comparative Study of the Pathology and Pathophysiology of Severe Malaria in a Non-Human Primate Model
… induced severe and cerebral malaria in humans. Using 30 years worth of archival samples at the Armed Forces Research Institute of Medical Sciences in Bangkok, Thailand, compounded with data and material from a series of prospective experimental studies, the work in this thesis sought to …
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Efficacy of using robotics to characterize impaired upper-limb function in a non-human primate model of stroke
… animal preclinical trials failed in subsequent human populations. Non-human primates (NHPs) closely resemble humans and may represent an animal model that could help bridge the translational gap preceding clinical trials. Additionally, robotic technology has been proven to provide objective …
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Evaluating compassion satisfaction and the risk of compassion fatigue among those working at non-human primate sanctuaries and wildlife centers
… study to explore compassion fatigue within the primate sanctuary field. Thirty-nine eligible participants completed an online survey that probed professional quality of life via the ProQOL 5, perceived workplace support via the Trauma-Informed Organizational Culture (TIOC) survey, observation …
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Characterization and Development of a Novel Cytomegalovirus for Evaluation as an HIV Vaccine Viral Vector in a Non-Human Primate Model
… to evaluate CMV-based HIV/SIV vectors in a non-human primate (NHP) model, I isolated CMV from cynomolgus macaques (CyCMV), and performed preliminary phenotypic and genomic classification of the novel virus. To characterize the CyCMV genome, facilitate targeted recombination for vaccine …
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An analysis of human Alu element lineages
… Elements (SINEs) found exclusively in primates. These lineages are comprised of several distinct subfamilies, which contain elements that are evolutionarily-related because they share common diagnostic mutations. Some of these Alu subfamilies are still actively mobilizing in the human …
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The Role of Hyaluronan in the Ocular Surface
… of HA in the limbal stem cell niche, primary human limbal epithelial stem/progenitor cells were isolated and expanded onto differently coated cultures with or without HA and the yield of limbal epithelial stem cells assessed. (2) To characterize the limbal stem cells niche, the ECM of the …
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A 24-channel radio frequency receive array for magnetic resonance imaging of primates at 10.5 T
… of MRI with a focus on RF coil construction for non-human primate (NHP) imaging. A 24-channel RF receive array coil with integrated transmitter is presented, followed by a discussion of its performance, imaging results, and future directions.
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The Influence of Alpha7 and Alpha4 Beta2 Nicotinic Receptor Agonists on Feature Based Reversal Learning in Macaque Monkeys
Selective and non-selective nicotinic agonists are associated with improvements in higher order cognitive functions. However, the effects of selectively activating nicotinic sub-receptors on attention and learning are not well understood. In my project, I used two agonists selective for alpha7 (7) …
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The Use of Fallback Foods in a Population of Black Handed Spider Monkeys at Runaway Creek Nature Reserve, Belize
… in preferred food availability cause some non-human primate species to occasionally rely on less-preferred food types, called fallback foods. Periodic reliance on fallback foods has led, in some cases, to the evolution of morphological traits geared towards their exploitation. However, in …
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The Cholesterol Transporter ABCA1 and Cholesterol Accumulation are Key Regulators of Adipose Function in Obesity
… to study adipose cholesterol. The first used a non-human primate model to determine the effect of additional dietary cholesterol on adipose tissue depots, and the second uses an adipose specific knock out of ATP Binding Cassette Transporter A1 (ABCA1) to study adipose cholesterol metabolism in …
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Scratching the Surface: A Content Analysis of Gorillas as Zoogeomorphic Agents
… planning. This study is a content analysis of non-human primate literature that utilizes a conventional approach to identify, categorize, and define cases of gorilla zoogeomorphic activity. Nine categories of how gorillas function as zoogeomorphic agents have been identified. They include: (1) …
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