Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Non-B DNA structures"”.
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Unveiling Global Roles of G-Quadruplexes and G4-22 In Human Genetics
<p>G-quadruplexes are non-B DNA structures formed by four or more runs of repeated guanines that confer unique features to living organism’s genomes. These sequences are enriched in regulatory regions, such as promoters and 5’ UTRs, and have distinct regulatory roles in both health and disease …
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Double-Strand Break Repair Pathways In Dna Structure-Induced Genetic Instability
… In the absence of exogenous sources of DNA damage, the DNA structure itself has been implicated in genetic instability. When the canonical B-DNA helix is naturally altered to form a non-canonical DNA structure such as a Z-DNA or H-DNA, this can lead to genetic instability in the form of …
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DNA topology and Pol II CTD phosphorylation as stepwise regulators of chromatin architecture in differentiating human stem cells
… from heterochromatin, and repositioned through DNA looping. While each of these features of Pol II regulation has been well studied in individual cell types, it remains unclear how a single genome can support hundreds of distinct fates. Combinatorial transcription factor binding explains part of …
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Computational analyses of non-canonical architectural and structural features associated with alternative splicing
… machines currently known. Even though the canonical splicing signals that drive the precise recognition of splice sites are well-characterised, recent advances in transcriptome profiling technologies and computational method development have enabled widespread identification of non-canonical …