Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Non small lung cancer"”.
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NOVEL THERAPEUTIC STRATEGIES IN LUNG CANCERSTRONG BIOLOGICAL BIAS FOR ALK INTRON 19 BREAKPOINTS IN NON-SMALL LUNG CANCER
… one of the most common genomic aberration in cancer and chromosomal translocation that lead to oncogenic kinase activation are observed in many solid tumors. These tumors express activated fusion kinases that drive the initiation and progression of the malignancy. In the last 15 years, several …
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The role of microvesicles in EMT and tumour microenvironment
… from healthy and unhealthy cells. The role of cancer cell derived-MV in intercellular communication gains an intensive aria of research. The influence of leukaemia cell derived-MVs in this study was determined on normal prostate epithelial cell lines. PNT2 cells were treated with Jurkat cell …
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Laying technological groundwork for Templated Assembly by Selective Removal (TASR) at biological length scales
… selective self-assembly of mammalian as well as non-mammalian single cells into patterned hemispherical sites on rigid assembly templates using TASR. TASR-based size-selective assembly of biological systems represents a potentially valuable tool for biological applications from cell sorting and …
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EFFECT OF MICROTUBULE-TARGETING AGENTS ON STRUCTURAL SIGNALING AND CHEMICAL TRANSPORT IN CELLS
… remarkable efficacy against a wide spectrum of cancer types. Paclitaxel, a natural product extracted from yew tree bark, was the first microtubule-targeting agent (MTA) to be approved for clinical use in 1992, followed by two synthetic derivatives, docetaxel and cabazitaxel. These molecules bind …
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Identification and functional study of the bioactive peptide QUB-2417 from the skin secretion of the tree frog, Phyllomedusa bicolor
… assay, QUB-2417 exhibited bioactivity against lung cancer cell line NCI-H838 at the highest test concentration (10-4 M) and the value of IC50 was 35.3 µM. In the haemolysis bioassay, QUB-2417 exhibited about 30% haemolytic effect at the highest test concentration (128 μM) and the value of HC50 …
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Identification and functional study of a bioactive peptide QUB-2007 from the skin secretion of the bicolour tree-frog Phyllomedusa bicolor
… at a concentration of 8 μM. In terms of MTT anticancer cell proliferation assays, QUB-2007 was shown to have anticancer activities against HCI-H838 lung cancer cells at a concentration of 10-4 M. With regard to haemolysis, QUB-2007 was haemolytic at concentrations of 32 μM could be …
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Ca²⁺ and phosphoinositides regulations in α-actinin -4 F-actin binding.
α-actinin-4 is a non-muscle isoform of α-actinin that belongs to the spectrin superfamily. It comprises three functional regions: an N-terminal actin-binding region that consists of two calponin homology (CH) domains, a central region that consists of four copies of the spectrin-like repeat domain …
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Formulation of non-ionic surfactant vesicles for therapeutic delivery of siRNA in cancer treatment
… another type of lipid-based system known as non-ionic surfactant vesicles (NISV) which are commonly used for drug delivery of various therapeutic agents, are relatively safe and non-expensive have not been extensively studied for siRNA delivery. Therefore, the aim of this study was to …