Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Non small cell lung carcinoma"”.
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Surveillance Imaging Following Curative-Intent Surgery for Non-Small Cell Lung Carcinoma: A Systematic Review
Following curative surgery for non-small cell lung carcinoma (NSCLC), patients remain at risk for recurrence of lung cancer or for development of second primary lung cancer (SPLC). While periodic surveillance may detect early stage recurrence or SPLC, the effectiveness of surveillance has not been …
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Tumour Associated Neutrophils as a Potential Biomarker for Anti-PD-1 Immunotherapy in Non-Small Cell Lung Carcinoma: An Automated Approach
… and clinical biomarkers for the treatment of lung adenocarcinoma (LUAD), objective response rates are still low at around 20%. Current biomarkers are limited in their ability to stratify patients for predicting response, highlighting the need for novel biomarkers to better guide therapeutic …
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Epithelial to Mesenchymal Transition As A Predictor of Response to Polo-Like Kinase 1 Inhibition-Induced Apoptosis In Non-Small Cell Lung Carcinoma
<p>Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. Outcomes are poor for patients with recurrent, advanced or metastatic NSCLC. Polo-like kinase 1 (PLK1), involved in the regulation of mitotic processes and the response to DNA damage, is overexpressed in …
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The role of c-FLIP in regulating resistance to ionizing radiation
… strategies to improve the efficiency of cell death induction by ionizing radiation (IR) are required to improve therapeutic outcomes. FLIP, anendogenous caspase-8 inhibitor is a critical regulator of cell death that is frequently overexpressed in various cancers. FLIP overexpression in …
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The effect of insulin-like growth factor-I (IGF-I), and an IGF-I-like factor secreted by human lung fibroblasts, on the growth of human lung carcinoma cells in vitro
… factor I (IGF-I) in tissue taken from human non-small cell lung carcinoma (NSCLC) is 1.4- to 7-fold higher than the concentration of IGF-I in the surrounding normal lung tissue and therefore IGF-I may be involved in the growth of NSCLC. In this study it was determined that NSCLC cell lines …
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Expression of Leukemia/Lymphoma Related Factor (LRF) in Human Breast Carcinoma
… Its oncogenic role is known only in lymphoma, non-small cell lung carcinoma, and malignant gliomas. The functional expression of LRF in human breast carcinoma has not been confirmed. The aim of this study was to investigate the expression of LRF and propose a mechanism for its function in human …
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Optimization of BRAF V600 Assay as A 2-Step Real-time PCR Protocol
… abnormally active, which disrupts regulation of cell growth and division. Mutations in this gene have been found in cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, papillary thyroid carcinoma, non-small-cell lung carcinoma, gastric cancer, and even prostate cancer. …
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Regulatory roles of endothelial cells in cancer
… the biochemical regulatory impact of endothelial cells, the cells that line all blood vessels, in cancer. Our work draws from concepts in vascular repair and tissue engineering and extends the view of tumor vessels from perfusing tubes to delivery platforms lined with potent paracrine regulatory …
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Novel Paclitaxel Nanoparticles for Enhanced Therapeutic Effects in Breast Cancer
… agent for breast, ovarian, pancreatic and non-small cell lung carcinoma. Till date, PTX has been used as the first line of treatment for metastatic breast cancer. However, being biopharmaceutical classification system (BCS) class IV agent PTX suffers low solubility, poor permeability and …
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Elucidating the role of the EGFR-family members in cell motility through the use of novel engineered bivalent ligands
Non-small cell lung carcinoma (NSCLC) is the most common type of lung cancer and is the leading cause of cancer related mortality worldwide. The past decade has seen exciting advances in the development of targeted therapies for the treatment of NSCLC. However, the efficacy of such therapies in …
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Development of Models for the Action of Novel Anti-apoptotic Proteins using Gene Regulation, Pathway Analysis and Protein Structure Prediction
… genes. Some of these cancers, such as non-small cell lung cancer (NSCLC), can only be detected at an advanced stage and therefore have a low survival rate. <br/>This project was designed in collaboration with Morvus Technology Ltd with the goal of using modern bioinformatics tools to …
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An immunohistopathological and functional investigation of β3 integrin antagonism as a therapeutic strategy in cancer. Characterisation, development, and utilisation of preclinical cancer models to investigate novel ¿3 integrin anatgonists.
Tumour cell dissemination is a major issue with the treatment of cancer, thus new therapeutic strategies which can control this process are needed. Antagonism of integrins highly expressed in tumours is one potential strategy. The integrins are transmembrane glycoprotein adhesive receptors. Two of …
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Transcriptional functions of the corepressor Sin3A in skin
Upon activation in epidermal stem cells, the proto-oncogene c-Myc triggers their exit from the stem cell compartment resulting in an increase in progenitor cell proliferation and an induction in terminal differentiation. Whether c-Myc plays a direct transcriptional role in epidermal stem cell …
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Investigation of the molecular mechanisms underlying the invasive phenotype in a panel of lung cancer cell lines
… knowledge of the molecular mechanisms by which lung cancer cells acquire the capacity to invade. The research can be divided into two main sections a) Development of genetic tools for stable, targetable transgene overexpression, b) Investigation of the role of differential expression of a group …
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Leukemia/Lymphoma Related Factor in Human Prostate Carcinoma
… elderly population with PC being the most common non-dermatologic malignancy in men. Although epidermal growth factor (EGF) plays a major role in the growth of normal prostate and in the initiation and progression of both BPH and PC, the exact underlying mechanisms of its role in pathogenesis of …
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Characterizing T Cell Features of Atypical Lymphocytes for the Optimization of Adoptive Immunotherapies
… results. Two such populations are regulatory T cells (Tregs) and CAR (chimeric antigen receptor-modified) T cells. The functional role of Tregs in the immune system is non-canonical, in that they prevent hyper-inflammation and resolve immunopathology by constraining conventional immune cell …
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Ο ρόλος του σηματοδοτικού μονοπατιού Sonic Hedgehog στον καρκίνο του πνεύμονα
Με την εργασία έγινε μελέτη του σηματοδοτικού μονοπατιού Sonic Hedgehog σε 96 περιστατικά καρκίνου πνεύμονα με τη μέθοδο της ανοσοϊστοχημείας. Επίσης μελετήσαμε την πιθανή συμμετοχή του μεταγραφικού παράγοντα FoxM1 στο καρκίνωμα του πνεύμονα και την πιθανή συσχέτισή του με το μονπάτι του Hedgehog. …