Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Nogo-A"”.
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The Role of Nogo-A During Development of the Chick Central Nervous System
<p>Nogo-A is a potent inhibitor of axon regeneration that is expressed by myelin forming oligodendrocytes of the adult central nervous system (CNS). However, neuronal expression of Nogo-A during development suggests an additional role. Little is known about the putative functions of Nogo-A during …
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Effects of Neuronal Nogo-A on Properties of Excitatory Synapses of the Sensorimotor Cortex
… of the oligodendrocyte-associated inhibitor Nogo-A has shown great promise in promoting neuronal regeneration, sprouting, and plasticity, as well as functional recovery in rodent and primate models of CNS injury. The high expression of Nogo-A in neurons of the postnatal CNS led us to look for …
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The Role of Nogo-A in Memory and Neuronal Plasticity in the Aged Rodent Brain
… shown that immunotherapy directed against the Nogo-A protein, which is enriched on oligodendrocytes, improves recovery of skilled forelimb sensorimotor function in adult and aged rats after an ischemic stroke lesion to the sensorimotor cortex. Furthermore, this recovery was correlated with …
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Towards cell replacement therapy in Parkinson’s disease. Proteoglycans and Nogo-A as modulators of axonal growth in midbrain dopaminergic neurons
… fashion. In the third project, we studied how Nogo-A protein affects the survival and neurite growth in DNs. Nogo-A is a strong growth-inhibitory protein in the brain and spinal cord. Interestingly, in recent years, the growth- and survival-supportive role of Nogo-A in various types of neurons …
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Extended Treatment Window Exists for Improving Sensorimotor Recovery Using Anti-Nogo a Immunotherapy in Adult Rats with Chronic Stroke Deficits
… One potential therapy involves the use of anti-Nogo-A immunotherapy post-stroke. Our laboratory has shown that the administration of this novel treatment results in sensorimotor recovery in adult and aged rats. This therapy has been shown to be efficacious when applied immediately, 24 hours, and …
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Localisation and expression pattern of the Nogo receptor and its ligand, Nogo-A in cells of the mammalian central nervous system
… inhibitory molecules associated with myelin. The Nogo receptor plays a role in this process through an extraordinary degree of cross reactivity with three structurally unrelated myelin-associated inhibitory ligands namely; Nogo-A, myelin associated glycoprotein and oligodendrocyte myelin …
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The expression and functional analysis of neurite outgrowth inhibitors in the nervous system of Xenopus laevis
… to neurite growth, such as Tenascin-R (TN-R) and Nogo-A, have been identified in mammals. These proteins are associated with oligodendrocytes and myelin and are considered major inhibitory components of the CNS environment.
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Repulsive cues and signalling cascades of the axon growth cone
… conflict. My experiments also demonstrated that Nogo-δ20, a domain of Nogo-A, requires local protein synthesis to cause collapse. Unlike Semaphorin-3A, the dependence of collapse upon protein synthesis is concentration-independent and does not involve guanylyl cyclase, but it does share a …
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Effect of maternal separation on stress-related proteins measured in a 6-hydroxydopamine rat model of Parkinson’s disease
… chondroitin sulphate proteoglycans (CSPGs) or Nogo-A.
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Characterising the role of GPR50 in neurodevelopment and lipid metabolism
… the actions of the neurite outgrowth inhibitor NOGO-A. Existing evidence also indicates a role in lipid metabolism; GPR50 knockout mice displayed abnormalities in energy homeostasis and weight control, whilst sequence variants are associated with altered lipid levels in humans. Further, a …
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Response of sensorimotor pathways of the spinal cord to injury and experimental treatments
… blocking the function of the myelin inhibitors Nogo and MAG could enhance this plasticity. An electrophysiological approach was used to investigate these questions in rats which were subjected to a lesion of the dorsal columns at the C4/5 segmental level. This lesion interrupts the main …