Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Nod1"”.
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Nod1 and Nod2 in Innate Immune Responses, Adaptive Immunity and Bacterial Infection
… and RIGI-like helicase receptor (RLH) families. Nod1 and Nod2 are members of the NLR family of proteins, which are responsible for the recognition of components derived from the bacterial cell wall, more precisely, moieties of peptidoglycan. As such, Nod1 and Nod2 are implicated in the …
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Functional Characterization of the Avian Inflammatory Mediators Nod1, MIF and IL-22
… oligomerization domain protein 1 (Nod1) and Nod2 initiate host innate immune response by recognition of specific bacterial molecules, resulting in the production of pro-inflammatory cytokines, chemokines, and anti-microbial peptides. A candidate sequence of chicken Nod1 (ChNod1) was …
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Regulating the stabilities of NOD1 and NOD2, two innate immune receptors, with sugars and chaperones
… domain containing proteins 1 and 2 (NOD1 and NOD2), members of the NOD-like receptor family (NLRs). These NLRs recognize different fragments from bacterial cell wall peptidoglycan (PG) using their C-terminal leucine rich repeat (LRR) domains and then signal the body to deploy an …
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Nitrogen fixation potential and agronomic evaluation of three hypernodulating mutants of soybean
The three hypernodulating mutants (NOD1-3, NOD2-4, and NOD3-7) of soybean (Glycine max (L.) Merr.) and the parent (Williams) were evaluated for short-term NO$\sb3\sp-$ effect on N$\sb2$ fixation, measured by an acetylene (C$\sb2$H$\sb2$) reduction assay and by the relative ureide abundance …
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The Roles of Free Fatty Acids and Inflammation in β-Cell Dysfunction
… induced selectively by fat. The intracellular NOD1 receptor of innate immunity also affects metabolism, however its role in β-cell function is unknown and was the focus of the third study. Mouse and human islets expressed NOD1 mRNA, the NOD1 activator FK565 decreased β-cell function and NOD1-KO …
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Feedback regulation of nitrogenase and response of a hypernodulating soybean mutant to increased photosynthate supply
… tripled from 509 to 1753 nmol g$\sp{-1}$ FW in NOD1-3 (a hypernodulating mutant). These results are consistent with the idea that the feedback control of nodulation and nodule activity is located in the shoot and indicated that asparagine may be the signal molecule involved in sensing of soybean …
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Soybean (Glycine max (L.) Merr.); nodulation mutant characterization: Role of isoflavonoid, nitrate, and abscisic acid in nodulation control
… extracts from selected hypernodulating mutants (NOD1-3, NOD2-4, and NOD3-7), a nonnodulating mutant (NN5), and the Williams parent. There were no significant differences in isoflavonoid concentrations of root extracts among lines when plants were not inoculated, while all mutants had higher …
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Intracellular triggering of inflammation by the extracellular bacterium Pseudomonas aeruginosa
… to a transfection reagent. Finally, the role for Nod1 in infection by P.aeruginosa was explored. We could not identify Nod1-dependent NF-κB-activation using luciferase reporter gene assays. We therefore hypothesise that Nod1 does not have a role in the innate immune response to P.aeruginosa. In …
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Identification of novel genetic determinants in the high prevalence early-onset inflammatory bowel disease population in Scotland
… variants in putative susceptibility genes (NOD1/CARD4, IL23R, ATG16L1, IRGM, FLG) was performed to enable single variant and haplotype-tagging association studies. Genotypic data of population-matched healthy controls were obtained locally (n=342) and from the Wellcome Trust Case Control …
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Novel Functions of ATG16L1 in the Innate Response to Invasive Bacterial Pathogens
… ATG16L1 in the inflammatory response driven by NOD1 and NOD2, which are intracellular sensors of bacterial invasion. Secondly, we identified an interaction between complement C3, the central component of the complement cascade, and ATG16L1. This interaction allows for efficient targeting of …
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Role of NOD2/RIP2 signaling in acute bacterial pneumonia and sepsis
… is an adaptor for the nod-like receptors (NLR) NOD1 and NOD2. Nucleotide oligomerisation domain 2 (NOD2) is an intracellular PRR that is shown to be important for host defense against intracellular bacterial pathogens. However, the role of NOD2 and RIP-2 during Gram-negative bacterial pneumonia …
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Characterisation of a novel interaction partner for Atg16L1 and its role in regulating autophagy
… between the pathogen recognition receptors NOD1/2 and Atg16L1. The NOD receptors are activated by bacterial peptidoglycan (PG), which has been shown to drive autophagy. Interestingly, MEKK4 inhibits NOD2 signalling by binding the downstream adaptor protein RIP2, leading to the hypothesis …