Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 88 for “"Nociception"”.
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Bioactive Lipids in Nociception
This thesis focuses on bioactive lipids as (1) metabolites of the widely used antipyretic and analgesic drug acetaminophen and (2) activators of the ion channel TRPV1, an important downstream target for inflammatory mediators, in the phospholipase C (PLC)/TRPV1 signaling pathway. Evidence is …
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Measuring Nociception Under Anesthesia
… US alone. The problem of monitoring and managing nociception, the flow of information associated with harmful stimuli through the nervous system even when unconscious, in real time is critical during surgery. While there are measures to assess unconsciousness, immobility, and physiologic …
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Estrogen Signaling in Trigeminal Nociception
Migraine is much more common in women than in men, and painful episodes are linked to the hormonal fluctuations of the menstrual cycle. The MAP kinase extracellular-signal regulated kinase (ERK) is activated in experimental models of chronic pain, and is also activated by estrogen in sensory …
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Regulation of Visceral Nociception by GPR35
… the GPR35 receptor in the regulation of visceral nociception. Our *in-silico* analysis of previously published transcriptomic data reveals significant co-expression of GPR35 with noxious transducer TRPA1 in the nociceptive neuronal population of colonic DRG neurons. We showed that stimulation of …
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Modeling Alterations In Nociception Following Repeated Vaso-Occlusive Episodes
… exposure to ET-1 early in development alters nociception later in development via sex-dependent regulation of the ETB receptor. Three specific aims were undertaken to test this hypothesis. In Specific Aim 1, a behavioral characterization of age- and sex-specific ET-1 induced nociception was …
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Role of Transient Receptor Potential (TRP) Channels in Nociception
… is one of the significant components of nociception. Several receptors have been proposed to underlie mechanosensation. The molecular entities responsible for mechanosensation are not fully understood. In this study, I have characterized the properties of TRPV4, a putative …
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The role of the lateral spinal nucleus in nociception
… poorly understood, but has been implicated in nociception. To investigate the function of this nucleus, three broad areas were investigated: responses to nociceptive stimuli, neurochemical relations to the NK-1 receptor, and projections from this nucleus to several brain centres, to try to gain …
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Heritability of Nociception and Antinociception in the Laboratory Mouse
… the existence of five fundamental ""types"" of nociception: (1) baseline thermal; (2) spontaneous responses to noxious chemical stimuli; (3) thermal hyperalgesia; (4) mechanical allodynia; and (5) afferent input-dependent hypersensitivity. To facilitate the identification of polymorphic, …
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Somatosensory evoked potentials (SEP) in relation to nociception and anesthesia
Contains fulltext : mmubn000001_02759100x.pdf (Publisher’s version ) (Open Access)
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Neural Circuit Dependence of Acute and Subacute Nociception in C. Elegans
<p>Nociception, the detection and avoidance of harmful cues, is a crucial system in all organisms. Animals use nociceptive systems to escape from substances that decrease survival, and can also modulate the threshold for avoidance behaviors to weigh the attractive features of an environment against …
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Effects of Single and Dual Orexin Receptor Antagonists on Trigeminal Nociception
Migraine is a prevalent neurovascular disorder that causes throbbing pain and disruptions in sensory perception. This disorder is mediated by the trigeminal nerve, which provides sensory innervation to the face, scalp, and meninges. Migraine pain is conveyed to the brain via the trigeminothalamic …
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Nociception and the Experience of Pain Signaling Due to Nerve Damage
<p>Hyperalgesia is the increased sensitivity to pain which can present itself to many people no matter age or ethnicity. Having the ability to alleviate pain whether it be acute or chronic pain without the use of addictive medication can have the potential to change the course or modern medicine …
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Neuronal and Molecular Basis of Nociception and Thermosensation in Drosophila melanogaster
… chemicals that are considered to be noxious. Nociception is defined as the neural encoding and processing of noxious stimuli. This process starts from the activation of pain detecting peripheral sensory neurons (nociceptors) that can detect noxious mechanical, thermal or chemical stimuli. On …
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Cellular and Genetic Bases of Cold Nociception and Nociceptive Sensitization In Drosophila Larvae
<p>Organisms from flies to mammals utilize thermoreceptors to detect and respond to noxious thermal stimuli. Although much is understood about noxious heat avoidance, our understanding of the basic biology of noxious cold perception is gravely minimal. Numerous clinical conditions disrupt the …
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Neuropeptides Amplify and Focus the Monoaminergic Inhibition of Nociception in <i>Caenorhabditis elegans</i>
… status can dramatically modulate olfaction and nociception. To better understand how food availability modulates olfactory responses, we examined the nutritionally-dependent, tyraminergic inhibition of aversive behavior mediated by the two nociceptive ASH sensory neurons in <i>C. elegans</i>. …
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Evaluation of the Functional Roles of TRPA1 Homologs, Painless and dTRPA1, in Chemical Nociception in Drosophila
… These are thought to be involved in chemical nociception, though the specific role of <italic>painless</italic> in the behavioral aversion to the compound, allyl isothiocyanate, is disagreed upon. We have analyzed the behavioral phenotypes of <italic>painless</italic> and …
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Slow Touch and Fast Nociception: Exploration of the Interactions Between Noxious and Innocuous Mechanical Touch Sensation
Human cutaneous somatosensation is a multimodal physiological process by which physical stimuli on the body surface activate neural substrates that consequently give rise to perceptions such as pressure/vibration, temperature, itch, and pain. When considering skin mechanosensation, the canonical …
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Τεχνική διασωλήνωσης με τη χρήση υψηλής δόσης ρεμιφεντανύλης και αξιολόγηση της μέσω του αλγαισθητικού δείκτη (Nociception index NOL)
… σε επιλεγμένες περιπτώσεις. Ο δείκτης Nociception Level Index (NoL) επιτρέπει αντικειμενική εκτίμηση της αλγαισθητικής/αντι-αλγαισθητικής απάντησης. Σκοπός: Σύγκριση της κλασικής τεχνικής διασωλήνωσης με ροκουρόνιο 0,6 mg/kg έναντι τεχνικής με υψηλή δόση ρεμιφεντανύλης 4 μg/kg χωρίς …
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PARTIAL SPINAL NERVE LIGATION ALTERS ANATOMICAL COMPONENTS OF OXYTOCIN SIGNALING AND THE LEVEL OF TONIC OXYTOCIN-MEDIATED INHIBITION OF NOCICEPTION
Chronic pain affects more than 25 million people in the United States of America, with neuropathic pain contributing to pain in 6-8% of this population. Chronic pain occurs after surgical interventions in approximately 10-40% of patients, but most patients recover without developing persistent …
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Neurochemical drivers of visceral pain: insights into the roles of interleukin-17 and the proton-sensing G protein-coupled receptor GPR68
… of infiltrating immune cells, further shapes nociception in the gut. For this reason, I also investigated the role of GPR68, a proton-sensing GPCR that is upregulated in colonic biopsies from individuals with IBD, expressed by colonic nociceptors, and contributes to disease severity, as shown …
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