Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"Nociceptin"”.
-
OPPOSING ROLES OF THE μ-OPIOID AND NOCICEPTIN/ORPHANIN FQ RECEPTORS IN OLIGODENDROCYTE DEVELOPMENT AND MYELINATION
… the balance between μ-opioid receptor (MOR) and nociceptin/orphanin FQ receptor (NOPR) activities in the OLGs. Furthermore, we found that myelination could also be affected by the FDA-approved methadone. A delicate balance between MOR and NOPR signaling may play a crucial role timing OLG …
-
Imaging Nociceptin Receptor Expression in Cannabis Use and Psychosis using Positron Emission Tomography with the radioligand [11C]NOP-1A
Nociceptin/orphanin FQ (N/OFQ) is a neuropeptide transmitter in the brain that can suppress neurotransmitter release, including dopamine and glutamate. Therefore, dysregulation of nociceptin opioid peptide receptor (NOPr) signaling can result in neurotransmitter imbalance, suggesting its putative …
-
Cellular Effects of Cerebral Ischaemia In Vitro’. Cerebroprotective Actions of GABAmimetic agents
… receptor agonist DCG-IV and the endogenous nociceptin receptor agonist nociceptin inhibited glutamate efflux whilst the group 1 mGluR antagonists MI’EP and CPCCOEt did not. These results demonstrate a good correlation between the effect of compounds on ischaemic glutamate efflux in vitro and …
-
Phasic Dopamine Signaling During Ingestion: Modulation Across the Need-to-Satiety Arc
… during ingestion. Systemic administration of nociceptin receptor antagonist, shown to influence the breakpoint in reward behavior, didn’t affect dopamine responses to water. In contrast, systemic treatment with GLP-1 receptors agonists, known to promote satiety, differentially modulated …
-
Papel do sistema peptidérgico da nociceptina/orfanina FQ no comportamento depressivo em camundongos
Introduction: Nociceptin/orphanin FQ (N/OFQ) is the endogenous ligand of a receptor coupled to Gi protein named NOP receptor. Both N/OFQ and NOP receptor are widely expressed in brain areas involved in emotional processing. Clinical and preclinical evidence suggests antidepressant effects due to …
-
PHARMACOGENOMICS OF OPIOID RESPONSE IN EUROPEAN ADVANCED CANCER PATIENTS
… is scarce, OPRL1 encodes the opioid related nociceptin receptor 1, belonging to the opioid receptor family. The identified polymorphisms were reported to be modulators of the expression of both PCMTD2 and OPRL1 genes, in eQTLGen database. Also, variants in the same chromosomal region were …