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Showing 1 to 11 of 11 for “"Nitroxyl (HNO)"”.
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The Role of Phospholamban Cysteines in the Activation of the Cardiac Sarcoplasmic Reticulum Ca2+ Pump by Nitroxyl (HNO)
… therapies, patient prognosis remains poor. Nitroxyl (HNO), a new candidate heart failure drug therapy, has been shown to enhance overall cardiovascular function in both healthy and failing hearts, at least in part, by increasing Ca²⁺ re-uptake into the CSR. Previous research has shown that …
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Phosphine-Mediated Ligations: A Powerful and Versatile Method for the Selective Chemical Detection of Nitroxyl
… platelet disaggregation and vasorelaxation. Nitroxyl (HNO), the product of NO reduction and protonation, increases myocardial contractility and elicits vasodilation, likely through modifications of select thiol proteins, a physiological profile distinct from NO.
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Long-wavelength, reaction-based, fluorescent sensors for HNO and mobile zinc
… Three of these species are nitric oxide (NO), nitroxyl (HNO), and mobile zinc. Maintaining the homeostasis of these signaling molecules is vital and a deeper comprehension of their roles could help in understanding the pathology of specific diseases associated with their dysregulation. One …
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Acyloxy Nitroso Compounds as HNO Donors and Their Reactions with Thiol and Heme Containing Proteins
Nitroxyl (HNO), a nitrogen monoxide with distinct chemistry and biology, has gained interest as a potential treatment of congestive heart failure through the ability of the HNO donor, Angeli's salt (AS), to evoke positive inotropic effects in canine cardiac muscle. The release of nitrite during …
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Interaction between RSNO and H2S: The formation, stability, and NO-donating capacity of SSNO- and the effect of SSNO- on platelet activation
… of ferricatalase, I have also shown that nitroxyl (HNO) release from SSNO- decomposition is unlikely. However, I have determined that NO is acquired from SSNO- in the presence of vacant heme. Indeed, our data shows that a vacant heme is necessary to acquire NO from SSNO-, which indicates a …
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The detection of nitric oxide and its reactivity with transition metal thiolate complexes
… have prepared a related sensor that will detect nitroxyl (HNO) but not NO. These systems demonstrate the versatility and value of the conjugated polymer scaffold for sensing applications. Many targets of the diatomic radical NO contain redox active units, such as transition metals or thiolate …
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Physical Mechanisms of Ca-ATPase Regulation in the Heart
… activity is not understood. Conversely, nitroxyl (HNO), a new candidate for drug therapy for congestive heart failure (CHF), improves overall cardiovascular function by increasing Ca-ATPase activity in the heart. However, the physical mechanism for this activation is unknown. Therefore, …
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Reactions of Nitroxyl and Nitrite in Blood
… Na<sub>2</sub>N<sub>2</sub>O<sub>3</sub>), a nitroxyl (HNO) and nitrite (NO<sub>2</sub><super>-</super>) donor, on plasma Hb oxidation, and on the vasoactivity of plasma Hb. Both HNO and nitrite are known to oxidize oxyHb to metHb. We hypothesized that AS could ameliorate hemolysis-associated …
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Developing Detection Methods for Nitroxyl
Accurate detection of nitroxyl (HNO) is essential to understanding its bioactivity, metabolism, and relation to health and disease. However, detection and quantitation of HNO has been complicated by the rapid self-consumption of HNO through irreversible dimerization, poor selectivity of trapping …
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Degradable Polymers for the Controlled Delivery of Bioactive Small Molecules
… methane, sulfur dioxide, hydrogen cyanide, and nitroxyl (HNO). This dissertation covers compounds that release HNO, which possesses similar functions to NO (cardioprotection and vasodilation) but has been studied much less. While HNO, H2S, and RSSH have vital biological functions, they also have …
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Vibrational many-body methods for molecules and extended systems
… hydrocarbon combustion chemistry: HCO$^+$, HCO, HNO, HOO, HOO$^-$, CH$_3^+$, and CH$_3$. We propose a hybrid, compact representation of PESs that combines the merits of two existing representations, which are a quartic force field (QFF) and numerical values on a rectilinear grid. We employed a …