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Showing 1 to 20 of 31 for “"Nitroxyl"”.
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Developing Detection Methods for Nitroxyl
Accurate detection of nitroxyl (HNO) is essential to understanding its bioactivity, metabolism, and relation to health and disease. However, detection and quantitation of HNO has been complicated by the rapid self-consumption of HNO through irreversible dimerization, poor selectivity of trapping …
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Reactions of Nitroxyl and Nitrite in Blood
… Na<sub>2</sub>N<sub>2</sub>O<sub>3</sub>), a nitroxyl (HNO) and nitrite (NO<sub>2</sub><super>-</super>) donor, on plasma Hb oxidation, and on the vasoactivity of plasma Hb. Both HNO and nitrite are known to oxidize oxyHb to metHb. We hypothesized that AS could ameliorate hemolysis-associated …
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Aliphatic Nitroxyl Radicals as Antifatigue Agents for Rubbers
The antifatigue activity of hindered nitroxyl radicals and their precursors have been studied. It was demonstrated that hindered alicyclic nitroxyl radicals and their precursors have weak antifatigue activities. However the trend increased in the order: amine < nitroxyl radical < hydroxylamine. The …
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A study of nitroxyl radical precursors as photostabilisers for polymers
The effects of different compounds on the melt stabilisation and the subsequent photostabilisation of Polypropylene have been studied under various processing conditions. Better melt and photo-stabilisation were obtained in the polymer films processed with the additives under restricted oxygen …
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The role of stable nitroxyl radical precursors as antioxidants in polyolefins
… and their N-alkyl derivatives of stable nitroxyl radical precursors containing acrylic(s) and methacrylic(s) groups were reactively processed in the presence of a peroxide as bound-antioxidant masterbatches for polyolefin stabilisation. It was found that grafting of the antioxidant …
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Phosphine Based Fluorescent Probes for Nitroxyl Detection and Their Reactivity Toward S-Nitrosothiols
Nitrogen oxides are a unique class of molecules with profound physiology. Nitric
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Phosphine-Mediated Ligations: A Powerful and Versatile Method for the Selective Chemical Detection of Nitroxyl
… platelet disaggregation and vasorelaxation. Nitroxyl (HNO), the product of NO reduction and protonation, increases myocardial contractility and elicits vasodilation, likely through modifications of select thiol proteins, a physiological profile distinct from NO.
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The Behaviour of Substituted Diaryl Nitroxyl Radicals and their Derivatives as Antifatigue Agents for Rubbers
A variety of arylnitroxyl radicals and their precursors have been evaluated as antifatigue agents, antioxidants and antiozonants in natural rubber. Nitroxyl radicals and their derived hydroxyl amines were shown to be the active species during fatiguing and mechanistic studies using ESR have shown …
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Elucidation of the quinone methide tautomer of riboflavin and generation of a flavin nitroxyl radical
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1981.
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The Role of Phospholamban Cysteines in the Activation of the Cardiac Sarcoplasmic Reticulum Ca2+ Pump by Nitroxyl (HNO)
… therapies, patient prognosis remains poor. Nitroxyl (HNO), a new candidate heart failure drug therapy, has been shown to enhance overall cardiovascular function in both healthy and failing hearts, at least in part, by increasing Ca²⁺ re-uptake into the CSR. Previous research has shown that …
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A study of mechanochemical reactions of spin traps in hydrocarbon polymers
… spin trapping techniques have been examined. The nitroxyl yield and polymer bound nitroxyl percentage formed from these spin traps were found to be strongly dependent on the nature of spin trap and radical generator, processing temperature, and irradiation time. The nitroxyl yield and % bound …
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Chemical modification of polymers
… Previous studies have shown that stable nitroxyl radicals function as stabilisers in polymer during processing (e.g. PP, PVC) by deactivating a large number of kinetic chains via a redox process whereby the concentrations of the nitroxyl and its reduced form, the hydroxylamine, fluctuate …
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Long-wavelength, reaction-based, fluorescent sensors for HNO and mobile zinc
… Three of these species are nitric oxide (NO), nitroxyl (HNO), and mobile zinc. Maintaining the homeostasis of these signaling molecules is vital and a deeper comprehension of their roles could help in understanding the pathology of specific diseases associated with their dysregulation. One …
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Applications of fluorescence spectroscopy to environmental chemistry
… mechanism of fluorescence quenching by stable nitroxyl radicals, which are becoming an important analytical tool for the study of reactive transients in surface waters (1, 2). In part two, quenching of dissolved organic matter (DOM) fluorescence by nitroxides is employed to investigate the …
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The mechanisms of melt stabilisation of polyolefins
… 5-cyclohexadiene-1- one (galvinoxyl), iodine, nitroxyl radicals and cupric stearate were found to be very efficient melt stabilisers particularly when processed in a restricted amount of air. The mechanisms of their melt stabilising action have been investigated and a common cyclical …
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Acyloxy Nitroso Compounds as HNO Donors and Their Reactions with Thiol and Heme Containing Proteins
Nitroxyl (HNO), a nitrogen monoxide with distinct chemistry and biology, has gained interest as a potential treatment of congestive heart failure through the ability of the HNO donor, Angeli's salt (AS), to evoke positive inotropic effects in canine cardiac muscle. The release of nitrite during …
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Hydroxyl radical additions to arenes
… of the reaction were trapped with TEMPO, a nitroxyl radical, then derivatized to allow for analysis and characterization by GC/MS. The ratios of ·OH addition products yield relative rate coefficients that may be subjected to Arrhenius analysis to probe the effect of structure on reactivity.
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Utilization of TMV-TEMPO as an in Vivo MRI Sensor of ROS Production in Liver Inflammation and as a DNP Agent
… PhD dissertation details the i) utility of a nitroxyl-modified tobacco mosaic virus (TMV) as an in vivo MRI contrast agent for detection of reactive oxygen species (ROS) in murine model of liver inflammation and ii) its feasibility as an agent in MRI signal-enhancing dynamic nuclear …
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Development of Sustainable Catalytic Systems For Oxidation Reactions
… alcohol oxidation using sterically unhindered nitroxyl radicals in combination with nitric acid. The aim is to broaden the substrate scope of the reaction, whilst using a cheap, abundant source of NOx. Chapter three explores the use of Pd(II) catalysed oxidative carbonylation for the synthesis …
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