Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"Nitroreductases"”.
-
DNA repair in bacteroides fragilis
… to non-toxic derivatives by nitroimidazole nitroreductases (encoded by nim genes). However, metronidazole resistance could also potentialIy be mediated by the over-expression or enhanced activity of DNA repair proteins. Thus, DNA repair in B. fragilis should be thoroughly investigated.
-
Regulation of a two-pore K+ channel by multiple subunits in Caenorhabditis elegans
… domain is similar to bacterial NADH nitroreductases that use an FMN cofactor. We identified a mutation in a predicted FMN-binding residue of SUP-18 that both eliminates its in vivo function without disrupting its membrane localization and that impairs the enzymatic activity of a …
-
Investigating the resistance that arises in Escherichia coli towards the furazolidone – vancomycin antibiotic combination : Master of Science (Biological Sciences) at Massey University, Manawatū, New Zealand
… affecting the key nitrofuran-activating nitroreductases NfsA and NfsB.
-
Analogues of Nitrofuran Antibiotics are Potent GroEL/ES Pro-drug Inhibitors with Efficacy against Enterococcus Faecium, Staphylococcus Aureus, and Escherichia Coli
… through mutations known to effect NfsA and NfsB nitroreductases, the resulting strains were not necessarily cross-resistant to the other inhibitors. Thus, combination therapy may help bypass these resistance mechanisms. In summary, this study identified key structure-activity relationships to …
-
Oncolytic adenovirus vectors for nitroreductase suicide gene therapy of prostate cancer
… are two previously characterised mutant nitroreductases, which show enhanced catalytic activity for the prodrug CB1954. The new nitroreductase expressing ICOVIR-7 vectors were characterised in terms of virus mediated cytotoxicity, tumour selectivity, E1A and NTR expression and …