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Showing 1 to 5 of 5 for “"Nitrogen mustards"”.
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The androgen receptor independent mechanism of toxicity of the novel anti-tumor agent 11[beta]-dichloro
… that do not express the AR, more so than other nitrogen mustards commonly used in chemotherapy. To understand better the AR independent mechanism, the toxicity of 116 -dichloro was investigated in Saccharomyces cerevisiae, by interrogating the complete yeast single-gene deletion mutant library. …
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Biological Consequences Of Complex Dna Lesions Induced By Bis-Electrophiles
… analogous to cellular DPCs induced by antitumor nitrogen mustards, were prepared by post–synthetic reductive amination. Further, Huisgen cycloaddition was used to generate DPCs involving the C5–thymidine of DNA. Replication bypass using human translesion synthesis polymerases η and κ revealed …
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Reductively triggered internal cyclisation reactions
… for the hypoxia selective release of aromatic nitrogen mustards. The observed pseudo-first-order rate coefficients of cyclisation of several model 2-aminoaryl-acetamides and propanamides have been measured. Cyclisation was observed to be strongly influenced by stereochemistry, whereas electron …
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The reaction of ethylene oxide with some proteins, amino acids and vitamins
… a purified diet as the sole source of amino acid nitrogen. Thorough drying of the proteins reduced the extent of subsequent fumigation damage. The nutritional quality of the three proteins was completely restored by the supplementary feeding of L-histidine-HCl, DL-methionine, and L-lysine-HCl, or, …
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ΣΥΝΘΕΣΗ ΤΡΟΠΟΠΟΙΗΜΕΝΩΝ ΣΤΕΡΟΕΙΔΩΝ ΕΣΤΕΡΩΝ, ΜΕ ΠΑΡΑΓΩΓΑ ΤΗΣ Ν, Ν-ΔΙΣ(2-ΧΛΩΡΟΑΙΘΥΛ)ΑΝΙΛΙΝΗΣ ΚΑΙ ΒΙΟΛΟΓΙΚΗ ΔΡΑΣΗ ΑΥΤΩΝ
… METHODS. THE ALHYLATING AGENTS USED WERE THE MUSTARDS OF PHENYLOCETIC, PHENOXYACETIC, PHENYLBUTYRIC AND BENZOIC ACID RESPECTIVELY, AND THE STEROIDAL ALCOHOLS WERE EPI-ANDROSTERONE, CIS ANDROSTERONE, DEHYDRO-EPI-ANDROSTERONE, TESTOSTERONE, ESTRONE, PREGNENOLONE AND ANDROSTANALONE.