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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Nitrobenzyl"”.
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A Mechanistic Study of the Reactions of 4-Nitrobenzyl Halides With Sodium Hydroxide in Aqueous Ethanol
The reaction of 4-nitrobenzy1 chloride and sodium hydroxide in ethanol, has been observed to give 4,4' - dinitrostilbene, while 4-nitrobenzy1 bromide under similar conditions, gave 4-nitrobenzy1 ethyl ether . The purpose of this study was to determine mechanisms for these two reactions, …
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Synthetic Materials with Redox-Triggers for Imaging and Drug Delivery
… trimethyl-locked quinone propionic acid and nitrobenzyl moieties. Novel redox-sensitive polymeric nanoparticles and micelles were prepared from a synthesized monomer containing trimethyl-locked quinone propionic acid as a redox trigger. A hydrophobic cancer drug, Paclitaxel, was incorporated …
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Crystal Engineering of Pharmaceuticals: Modulating Physicochemical Properties of Active Ingredients by the Formation of Cocrystals
… during the preparation of chlorpropamide-2-nitrobenzyl alcohol, high Z prime crystal (Z’=3) of 2- nitrobenzyl alcohol is serendipitously identified. In conclusion, crystal engineering based cocrystallisation is a viable technology for modulating physicochemical properties of pharma and …
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The fast atom bombardment mass spectrometric analysis of the carbamate pesticide carbaryl
… using both 2-nitrophenyloctyl ether (NPOE) and 3-nitrobenzyl alcohol (NBA) as matrix liquids. The sample was applied by three different techniques; simple mixing, solvent mixing and surface precipitation. Smaller volumes of matrix liquid were found to produce more favourable ion currents. …
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The development and applications of unsymmetrical diboron compounds
… also discussed. In this project, a series of 𝑜-nitrobenzyl ligands containing a disulfide group as the anchor to gold surfaces are synthesized. The 𝑜-nitrobenzyl group uncages an amine upon photoexcitation. Attempts to make a water soluble analog failed, however, the mixture of methanol and …
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Self-amplifying degradable polyurethanes and their upcycling application
… The incorporation of a small amount of an ortho-nitrobenzyl carbamate unit as a photo-sensitive moiety in the polymer backbone enables basic amine species generation after UV irradiation for amplified degradation of Fmoc carbamate as the base-sensitive moiety in the polymer backbone. 1H NMR …
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Caged phosphopeptides and phosphoproteins : agents in unraveling complex biological pathways
… as compared to literature values of other ortho-nitrobenzyl derived caged compounds. A study in which these caged phosphopeptide tools yielded seminal information about the 14-3-3 protein family's involvement in cell cycle control successfully demonstrated the unique utility of these probes. …
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Estrogens Containing Alkylating Substituents: The Synthesis and Estrogen Receptor Interactions of Estradiol and Hexestrol Affinity Labels
… was measured using the colorimetric reagent 4-(p-nitrobenzyl)pyridine, and the bromo derivatives were found to be consistently more reactive than the chloro ones. Their reversible binding to the lamb uterine estrogen receptor was measured by competitive binding assays, and their irreversible …
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Synthese und Photochemie von photoaktivierbaren Biomolekülen
… mit einem (Cumarin-4-yl)methyl- bzw. einem 2-Nitrobenzyl-Gerüst eingesetzt. Entsprechende Syntheseverfahren wurden erarbeitet. Anschließend erfolgte eine umfassende physikalisch-chemische sowie photochemische Charakterisierung der erhaltenen caged Verbindungen. Dabei wurde besonders auf gute …
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An Anion Selective Aminocyclodextrin Ion Channel: Ion Selectivity, pH Sensitivity and Potential as a Scaffold for Light Gating
… and nano-switches. A new photocleavable o-nitrobenzyl dimeric tether has been developed as a potential trigger for the photoactivation of the ion channel. The utility of the tether was demonstrated by functionalizing primary, secondary and benzylic alcohols with the tether and subjecting …
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Synthesis and Characterization of Redox-Sensitive Polymer and Prodrug for Targeted Drug Delivery
… By covalently conjugating a redox-trigger (p-nitrobenzyl alcohol) and self-immolative linker (p-hydroxybenzyl alcohol) to the cyclization spacer (n-2-(hydroxyethyl)ethylene diamine), a novel self-immolative monomer was obtained. Polymerization of the respective monomer yielded a linear …
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Synthetic and mechanistic studies in polynitroaromatic chemistry.
… nucleophilic qualities, though reaction with p-nitrobenzyl bromide was successful. An ultraviolet and nmr spectroscopic study of this reaction provided evidence to suggest that O'-adduct formation facilitates an ionic substitution reaction; whereas in other cases such O-complex formation is not …
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The preparation of lanthanide macrocyclic complexes for use as MRI and luminescence contrast agents
… the ligand l,4,7-tris(carboxymethyl)-10-(l-(4-nitrobenzyl)-2-methyl benzimidazole)-1,4,7,10-tetraazacyclododecane (34) is 6.22 mM"1 s" 1 , with the relaxivity of the gadolinium(III) complex formed with 1,4,7-tris(carboxymethyl)-10-( 1 -(4-aminobenzyl)-2-methyl …
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Development and Application of Covalent-Labeling Strategies for the Large-Scale Thermodynamic Analysis of Protein Folding and Ligand Binding
… are modified with dimethyl (2-hydroxyl-5-nitrobenzyl) sulfonium bromide and hydrogen peroxide, respectively. This so-called Hybrid protocol was applied to proteins in yeast and MCF-7 cell lysates and achieved a ~50% increase in proteomic coverage compared to probing only …
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Engineering a Photo-Control Mechanism for RNA Interference
… capacity. A novel cage group, 4,5-dimethoxy-2-nitrobenzylamine, was synthesized and used for the conversion of chloropurine riboside triphosphate and the corresponding free nucleoside. Base-caged ATPs were inactive until photoexposure to 365nm light. Additionally, these compounds did not …
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Next-Generation Oligonucleotide Probes For Transcriptome In Vivo Analysis (tiva)
… of the target cell severs photoactivable o-nitrobenzyl- or Ru(II) polypyridyl-based linkages built into the probe, freeing the poly(U) capture sequence to effectively biotinylate mRNA. After photolysis, a small tissue region containing the target cell is aspirated out and lysed so that the …
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Reductively triggered internal cyclisation reactions
… varied in the nature of substitution of the nitrobenzyl ring, 4-substitution of the leaving aniline, and overall geometry. Cyclisation via the hydroxylamino was observed to be significantly faster than that of its amino counterparts, and was similarly influenced by changes in geometry. The …
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CONSTRUCTING NANOSTRUCTURES WITH ATOMIC PRECISION: THE SYNTHESIS OF SPIROLIGOMER-BASED MACROCYCLES
… approach makes use of a protecting group, para-nitrobenzyl carbamate, which has not previously been incorporated in bis-amino acids as well as a pentafluorophenol ester activation strategy that also has not been in the synthesis of spiroligomers. Finally, an extendable synthetic route to …
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4D Control of Tissue Development and Blood Vasculature using Photo-mediated Chemistries
… are modified with a photodegradable ortho-nitrobenzyl moiety. Combining this novel material with a programmable multiphoton laser, blood vessels are generated with complete 4D control to create multicellular vascularized tissues with some of the most complex vessel networks to date. These …
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