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Showing 1 to 20 of 274 for “"Nitric Oxide(NO)"”.
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Study of the Evolutionary Role of Nitric Oxide (NO) in the Cephalochordate Amphioxus, “<i>Branchiostoma lanceolatum</i>”
Nitric Oxide (NO) is a gaseous molecule that acts in a wide range of biological processes. NO can be produced by enzymatic and non-enzymatic pathways and, in this scenario, the enzyme Nitric Oxide Synthase (NOS) has a great importance for its exclusive role in <i>de novo</i> synthesis of NO. In the …
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Regulation of skeletal muscle glucose uptake during contraction/ exercise by nitric oxide (NO)/ neuronal nitric oxide synthase MU (NOSμ)
… insulin-stimulated muscle glucose uptake and is normal in humans with type 2 diabetes (T2D) and in diabetic rodent models. A number of candidates have been implicated to play a role in the regulation of skeletal muscle glucose uptake during contraction and it is likely that there is some …
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Vasomotor and anti-oxidant effects of anti-ischaemic therapies.
Nitric oxide (NO) plays a fundamental role in vascular homeostasis including vasomotor tone, platelet adhesion and aggregation. The current studies examine various aspects of NO responses, including: the methodology for assessment of vascular NO responses, and identification of factors reponsible …
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Phosphine-Mediated Ligations: A Powerful and Versatile Method for the Selective Chemical Detection of Nitroxyl
Nitrogen oxides are a class of small molecules with profound physiological and environmental consequences. Nitric oxide (NO), the most well-known of these, is a key endogenous signaling agent effecting platelet disaggregation and vasorelaxation. Nitroxyl (HNO), the product of NO reduction and …
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Newly Designed HNO Triggered Prodrugs
Nitric oxide (NO) is an important species in many biological processes. The one-electron reduced and protonated derivative of NO, HNO has also been determined to play important biological roles. Because of HNO’s high reactivity, its detection has been difficult and many methods including …
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Nitric oxide influences muscle physiology and meat quality
The physiological role of nitric oxide (NO) has emerged as a regulator of many cellular processes. Importantly, the formative enzyme NO synthase (NOS) was found to have high levels of activity in skeletal muscle and the activity of the neuronal isoform of NOS was higher in muscle than in the brain. …
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The Roles of Peroxynitrite and Superoxide in Oxidative Damage to E. Coli
Peroxynitrite (ONOO$\sp{-}),$ a toxic biomolecule produced from the reaction of superoxide and nitric oxide (NO$\cdot)$ in the phagolysosome, may also be toxic by the same mechanism as O$\sb2{-}.$ Our in vivo results indicated that peroxynitrite has the same intracellular targets as superoxide. Of …
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The Mechanism of Oxygen and Nitric Oxide Toxicity in Escherichia Coli
The presence of nitric oxide (NO) greatly accelerates the rate at which hydrogen peroxide (H2O2) kills E. coli. The goal of this study was to determine the mechanism of this synergism. The filamentation of the dead cells, and their protection by cell-permeable iron chelators, indicated that NO/H2O2 …
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Salivary Reduction of Dietary Nitrate
Nitric oxide (NO) is an important cellular signaling molecule known mostly for its vasodilatative effects. Nitrate (NO3-) acts as an important NO source through reductive physiological pathways. Basal plasma NO3- levels are a sum of the oxidation of endogenous NO and ingested dietary NO3-. …
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LA VARIANTE ASSOCIATA ALLA LONGEVITA' (LAV) DEL GENE BPIFB4 MODULA eNOS E LA FUNZIONALITA' VASCOLARE
… polymorphisms (SNPs) that influence aging, a phenomenon associated with progressive decline in nitric oxide (NO) production and impairment of endothelial function. Preliminary data have shown that a variation of the bactericidal/permeability-increasing fold-containing family B member 4 (BPIFB4) …
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Examining effects of milk ferment components on endothelial cell signaling in pro-inflammatory pathways
… to, has been a growing health care and economic concern over the last 50 years. Bioactive peptides found in fermented milk have been shown to have cardio and athero-protective effects, but their mechanism has not been fully elucidated. The objective of this study was to test individual …
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Laser diagnostic investigation of the structure of steady and driven hydrogen jet diffusion flames
… fluorescence (LIF) to obtain temperature and nitric oxide (NO) concentrations in steady laminar flames and during the interaction of induced fuel-side vortices with the diffusion flame sheet. The accuracy of the CARS system was evaluated by comparing experimental temperature measurements from …
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Novel protocols to induce tolerance to solid organ transplants
… state however, DCs acquire a tolerogenic phenotype. When activated by TLR ligands, DCs undergo metabolic re-programming and switch to TBK1/IKKe/AKT-induced glycolysis at the early activation phase, which is sustained due to nitric oxide (NO)-mediated inhibition of mitochondrial metabolism at …
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The mechanism for paraquat toxicity involves oxidative stress and inflammation : a model for Parkinson's disease
… disease (PD) is a neurodegenerative disorder known to affect the dopaminergic neurons in the substantia nigra. Epidemiological studies have shown an increased risk of developing PD with exposure to paraquat. In this study, we examined the source of reactive oxygen species (ROS) and the …
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Evolution of Nitrogen Oxide(s) From Soybean and the Association of This Activity to the Constitutive Nad(p)h-Nitrate Reductase Enzyme
… Williams) and winged bean (Psophocarpus tetragonolobus (L.) DC. cv Lunita) leaflets. Nitric oxide (NO) and nitrous oxide (N$\sb2$O) were identified as the main N products formed. NO and N$\sb2$O produced from soybean leaflets were both labeled with $\sp $N when $\sp $N-nitrate was used in the …
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The Effect of Surface Structure on the Decomposition of Nitric-Oxide and Ammonia on Platinum
… programmed desorption (TPD) was used to compare nitric oxide (NO) decomposition on Pt(100), Pt(411), and Pt(211). The three surfaces were predicted to have similar orbital availabilities but different site densities. The measured dissociation fractions were 66, 70, and 66% on Pt(100), Pt(411) and …
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Macromolecular Complexes of Cystic Fibrosis Transmembrane Conductance Regulator Alter Fluid Transport in inflammatory Bowel Disorders
… physical and functional coupling of CFTR with nitric oxide (NO) producing enzyme-inducible nitric oxide synthase (iNOS) at the apical plasma membrane in inflammatory bowel disease (IBD). The complex formation requires the scaffolding protein Na+ /H+ exchanger regulatory factor 2 (NHERF2). We …
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Biophysical Studies Aimed at Potential Therapies of Hemoglobin Associated Diseases
… (RBC), carries gases like oxygen and carbon dioxide throughout the body. However, various conditions, both genetic and environmental, can impede its ability to perform this (and other) necessary functions. We studied some of the most imperative properties of Hb and the RBC as they pertain to …
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Neuronal Nitric Oxide synthase regulates the expression of EAAT4 and GAD65/67 in the murine cerebellum
… fibers (PFs) that produce high levels of nitric oxide (NO) via neuronal nitric oxide synthase (nNOS). Previous studies demonstrate that nNOS/NO signaling is crucial for PF-PN synaptic transmission. This study sought to examine nNOS/NO signaling regulation of excitatory amino acid …
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