Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Nippostrongylus brasiliensis"”.
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The influence of maternal Nippostrongylus brasiliensis infection on immunity in offspring
… system by maternal infection with the helminth Nippostrongylus brasiliensis (Nb) prior to pregnancy and its effect on control of the Salmonella enterica serovar typhimurium (STm) in offspring. We show that maternal Nb infection in BALB/c mice results in the transfer of Nb antigen (NES)-specific …
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The role of IL-4Rá in Nippostrongylus brasiliensis-induced chronic lung pathology
Infection by the parasitic nematode Nippostrongylus brasiliensis involves migration through the lungs, causing significant damage and generating chronic lung pathology. The resolution of N. brasiliensis infection and also the induction of pulmonary pathology, including goblet cell hyperplasia and …
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Preconception maternal exposure to Nippostrongylus brasiliensis transfers protection against Nb to her offspring
… in mice, maternal infection with the helminth Nippostrongylus brasiliensis is not only associated with a passive transfer of antigen specific antibody(IgG1) but also inherently alters offspring immunity, increasing offspring cytokine production, alveolar macrophages, lung neutrophils and B cell …
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Protective immunity against Nippostrongylus brasiliensis requires antigen presentation by IL-4Rα responsive B cells
Nippostrongylus brasiliensis is a parasitic nematode infection that affects rodents. B-cells have been shown to play an important role in immunity to many different infections by antibody production and T-cell activation. But B-cell function in the protective TH2 response against N. brasiliensis …
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The function of IL-4Rα expression on key immune cells during experimental Nippostrongylus brasiliensis infections
… of the parasitic nematode Nippostrogylus brasiliensis resembles that of the human hookworms Necator americanus and Ancylostoma duodenale and as such is a useful murine model for studying hookworm disease.
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Investigation of enteric neuron and type 2 lymphocyte interactions at homeostasis and during Nippostrongylus brasiliensis infection
… conditions and after infection with *Nippostrongylus brasiliensis* (*N. brasiliensis*). Analysis of publicly available single cell RNA-sequencing data revealed one subset of enteric cholinergic neurons, termed NMU-ergic neurons, which express genes encoding known regulators of ILC2s …
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Influence of helminth infection on vaginal immunity
… using the mouse model of hookworm infection, Nippostrongylus brasiliensis. Nippostrongylus brasiliensis infection of wild type BALB/c mice resulted in increased B cells, IgG1+ B cells and IgG1+ follicular B cells as well as increased effector memory T cells and T follicular helper cells in …
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The role of interleukin-4 receptor alpha on smooth muscle cells during helminth infection
… for effective host protection during murine Nippostrongylus brasiliensis (N. brasiliensis) and Schistosoma mansoni (S. manson!) infection. Among other cell types, IL-4Ra responsive smooth muscle cells influence immunological responses and are needed for host protection during N. brasiliensis …
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Role of M3 muscarinic receptor in regulation of immunity to infectious pathogens
… immunity to two pathogens; the nematode Nippostrongylus brasiliensis and the bacterium Salmonella enterica sp. Tyhpimurium. M3R deficient mice (M3R-/-) were susceptible to infection with N.brasiliensis with decreased production of the protective cytokine IL-13. Furthermore, stimulation of …
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Cancer cell behaviour following parasite exposure
… results revealed that antigen from the hookworm Nippostrongylus brasiliensis significantly reduced cervical cancer cell migration and the expression of two markers of metastasis: vimentin and N-cadherin. Importantly, N. brasiliensis antigen significantly lowered the expression of cell-surface …
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CD23's Role as a Negative Regulator of Allergic Disease: in vivo Effects of Murine CD23 Destabilization and Allelic Mutations
… was consistent with a more rapid clearance of Nippostrongylus brasiliensis from the gut of 129/SvJ mice. B cells from 129/SvJ spleens proliferated more rapidly than those from BALB/c after stimulation with IL-4 and CD40 ligand trimer in vitro. However, in vitro IgE levels in supernatants from …
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The role of pulmonary innate and adaptive immune responses to helminth infection
… immunity can contribute to pulmonary control of Nippostrongylus brasiliensis infections. Murine reinfection studies with the parasitic nematode N. brasiliensis have shown development of a Th2 CD4+ T cell responses in the lung to be essential for immunity to secondary N. brasiliensis infection. To …
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The role of pulmonary innate and adaptive immune responses to helminth infection
… immunity can contribute to pulmonary control of Nippostrongylus brasiliensis infections. Murine reinfection studies with the parasitic nematode N. brasiliensis have shown development of a Th2 CD4+ T cell responses in the lung to be essential for immunity to secondary N. brasiliensis infection. To …
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Alterations in preconception, antenatal, and postnatal maternal gut microbiota influence offspring intestinal microbiota and immunity
… or gestation plus nursing were susceptible to Nippostrongylus brasiliensis (Nb) infection. In the second study, we infected female BALB/c mice with 500Nb L3 three weeks prior to mating and examined the effect of preconception helminth infection on offspring microbiota and immunity. …
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Bystander influence of nematode exposure on subsequent herpesvirus infections in vivo
… the systemic influences of murine nematode Nippostrongylus brasiliensis infection on host immunity in colonized and non-colonized tissues, and the implications of these effects on susceptibility to subsequent herpesvirus infections in vivo. We show that prior N. brasiliensis infection …
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Early-life immunity and susceptibility to Mycobacteria
… effect of maternal helminth infection (Nippostrongylus brasiliensis) on BCG infection in offspring, with reduced lung bacterial burden and increased numbers of activated CD4+ T cells and B cells. Maternal Nb infection may have a synergistic effect on BCG vaccination, as …
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The control of Foxp3+ regulatory T cell by interleukin-4 receptor alpha-mediated signaling
… helminth infection with the parasitic nematode, Nippostrongylus brasiliensis, Foxp3cre IL-4Rα-/lox mice showed a higher level of mucus and exaggerated emphysematous pathology in the lungs. Interestingly, the impairment of IL-4Rα signaling within the Foxp3+ Treg population in Foxp3cre IL-4Rα-/lox …
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Regulation of HPV infection and cervical cancer development following a helminth infection
… exposure to soma7c helminth an7gens from Nippostrongylus brasiliensis and Heligmosomoides polygyrus bakeri decreased HPV PsV infec7on in two cervical cancer cell lines and one primary kera7nocyte cell line (the target cell of HPV). Similarly, exposure to the excretory-secretory (ES) …
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Development of vaccines against allergic asthma using products derived from intracellular bacteria or helminths
… Produkt des Helminthen Nippostrongylus brasiliensis, als ein neues mögliches Adjuvant zur Unterdrückung allergischer Reaktionen untersucht. Die Applikation von NES zusammen mit OVA/alum inhibierte deutlich die Entwicklung der Lungeneosinophilie, Becherzellmetaplasie und …
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The role of Cysteinyl leukotriene receptor-1 during experimental helminth infections in murine model
… immunity to helminth (Schistosoma mansoni and Nippostrongylus brasiliensis) infection in mice. The role played by cysLTs in the development of protective immune responses to helminth infections is not well documented. Hence in the present study, we investigated the role of cysLTs during …
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