Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Nipah virus"”.
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Elucidating Mechanisms of Immunity to Nipah Virus Infection through Generation of Attenuated Viruses and a Single-Cycle Vectored Vaccine
Nipah virus (NiV) is an emerging paramyxovirus that has caused outbreaks with high case-fatality rates in South and Southeast Asia. Mechanisms of NiV virulence are poorly understood, and there is no licensed vaccine nor treatment. Accessory proteins produced from the NiV P gene through …
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Exploring Nipah virus strain differences through use of recombinant and chimeric viruses as well as utilization of a novel 3D human lung model
Nipah virus (NiV) is a highly pathogenic paramyxovirus that causes lethal encephalitis and respiratory illness in humans. There are two variants of NiV - NiV Malaysia (NiVM) and NiV Bangladesh (NiVB). Despite high sequence homology between the strains, there are several key differences in …
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Nipah: The history, and future, of one of the world’s most lethal viruses
The Nipah virus kills around three quarters of people who contract it, making it one of the most lethal viruses known to infect humans. The virus first emerged in 1998, when hundreds of pig farmers in Malaysia fell ill with fevers and encephalitis, or brain inflammation. Nipah has caused smaller …
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The spread of Nipah and chikungunya viruses: implications for control
… to cause a substantial burden on public health. Nipah and chikungunya have been identified as two emerging viruses that pose a significant threat with pandemic potential. This has led to considerable investment in the development of vaccines against the two pathogens, especially by the Coalition …
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Virus-Based Nanoparticles for Tumor Selective Targeting and Oncolysis
… spectrum of malignancies. Newcastle disease virus (NDV), an avian paramyxovirus, is naturally tumor-selective and inherently oncolytic. Our approach is to develop NDV-based nanoparticles (VBNP) for oncolytic virotherapy. VBNPs are non-infectious and non-replicating and are relatively safe. We …
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Comparative Respiratory Tract Pathology of Emerging Viral Infections
… outbreaks have been caused by emerging zoonotic viruses. It has recently been estimated that there are at least 320,000 viruses in mammals that have yet to be discovered, some of which may affect humans. As humans continue to encroach upon previously isolated areas and have greater contact with …
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Regulation of the Human Parainfluenza Virus (hPIV3) Fusion Protein
<p>Paramyxoviruses include a number of important human pathogens, including measles virus, mumps virus, and the human parainfluenza viruses (hPIV) 1-4, as well as several animal pathogens, such as Sendai virus, Nipah virus and Hendra virus. The creation of effective drugs and vaccines against this …
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Are bats evolving more potent antiviral immune systems? Investigating the evolution and antiviral capacity of SERINC3 in Rhinolophus bats
… signs of disease. Several pandemic and emerging viruses have been traced back to different bat species, including SARS-CoV-2, SARS, Ebola virus and Nipah virus. Genetic positive selection analysis conducted in a recent study has revealed a pattern of antiviral immune genes under positive …
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Human Neural Stem Cell-Derived Neuron/Astrocyte Co-Cultures as a Model System to Study Emerging Encephalitic Viruses
… system as a model to study encephalitic virus infection. This system provides a more physiologically relevant model that maintains critical interactions between neurons and astrocytes. Two emerging encephalitic viruses were studied using this system, La Crosse virus (LACV) and Nipah virus …
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A strategy to suppress STAT1 signalling conserved in pathogenic poxviruses and paramyxoviruses
Vaccinia virus (VACV) is a member of the poxviridae, a family of viruses with large double-stranded, linear DNA genomes that replicate in the cytoplasm of cells. The genome of vaccinia encodes over 200 proteins, many of which have been shown to function as inhibitors of the innate immune response. …
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On Epitope-Paratope Interactions of Emerging to Endemic Viruses
… it’s a challenge to manage the spectrum of viruses across the world. The addressable viral spectrum ranges from emerging viruses such as Nipah virus (NiV), which appear sporadically as local zoonotic outbreaks with high mortality, to continually-evolving endemic viruses such as influenza A …
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Spillover and emergence of bat-origin viral infections
… model comparison of stochastic henipavirus serological dynamics in captive bats (Eidolon helvum in Ghana), a quantitative literature review of domesticated animals as bridging hosts of henipavirus and filovirus spillover, a statistical model of Ebola spillover observation …