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Showing 1 to 5 of 5 for “"NikR"”.
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Crystallographic studies of the metal-responsive transcription factor NikR
… permease complex, NikABCDE, mediated by the NikR metalloregulatory transcription factor. To understand how this takes place at a molecular level, X-ray crystallography was used to determine three- dimensional structures of the NikR. Structures of apo-NikR and Ni⁺²-NikR show an interesting …
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Computational and Experimental Investigation of Allosteric Communication in the Transcriptional Regulator NikR
The Ni<super>2+</super> and DNA binding protein NikR is involved in nickel regulation in <italic>Escherichia coli</italic> through transcriptional repression of the NikABCDE nickel permease. NikR is a homotetramer and each chain contains both a DNA binding ribbon-helix-helix: RHH) domain and a …
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Relating metal binding to DNA binding in the nickel regulatory protein NikR
… and can cause cell death. In Escherichia coli, NikR regulates nickel uptake by blocking transcription of the genes encoding the nickel uptake transporter, NikABCDE. NikR is a homotetrameric transcription factor with a central metal binding domain (MBD) that includes the tetrameric interface and …
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The evolution and regulation of DNA-binding by the nickel-dependent transcription factor NikR
… transcription factor NikR is a member of the ribbon-helix-helix: RHH) family of DNA-binding proteins and is widespread among bacteria and archea with vastly different nickel physiologies. The goal of this thesis was to better understand basic aspects of cellular …
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Discovery of a Novel Metalloregular Family: Structure/Function Studies of E. Coli Rcnr
… studied Ni-responsive metalloregulator NikR controls Ni import, this thesis describes the identification of RcnR, a novel regulator of Ni efflux. RcnR is the founding member of the RcnR/CsoR family of metalloregulators that are found throughout the eubacterial kingdom and respond to a …