Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 43 for “"Nigrostriatal"”.
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Prolactin Effects on Nigrostriatal and Mesolimbic Dopaminergic Neurons: In Vivo and In Vitro Studies
… to HPLC assay, the effect of prolactin on nigrostriatal and mesolimbic dopaminergic neuronal activity and its possible regulatory mechanism were examined.
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Changes in the Murine Nigrostriatal Pathway Following Pyrethroid and Organophosphate Insecticide Exposure: An Immunohistochemical Study
… properties that could damage or disrupt the nigrostriatal pathway, which is the principal neurodegenerative target in PD. The present study examined possible alteration of the amount of dopamine re-uptake transporter protein (DAT), within the striatum of the C57BL/6 mouse, using DAT …
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Synthetic and Natural Environmental Compounds as Potential Facilitators of Mptp-Induced Parkinsonism
… and this view is linked to the discovery of the nigrostriatal neurotoxin MPTP. MPTP can induce dopamine specific degeneration within the basal ganglia often resulting in motor deficits similar to PD. MPTP used in the C57BL/6 mouse is a widely used animal model of PD. The pyrethroid permethrin …
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Neuroprotective Effects of FGF20 on Dopamine Neurones
… to dopamine neurones and glial cells in the rat nigrostriatal tract and in VM embryonic dopamine neurone cultures. In vitro, FGF20 protected VM embryonic dopamine neurones against 6OHDA toxicity, and, in vivo, chronic supra-nigral delivery of FGF20 protected nigrostriatal dopamine neurones …
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Study on the Neuroprotective Effects of Ethyl pyurvate in MPTP-induced Mouse PD Models
… ethyl pyruvate (EP) promotes the survival of nigrostriatal dopaminergic (DA) neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson’s disease. MPTP induced degeneration of nigrostriatal DA neurons and glial activation as visualized by tyrosine hydroxylase, …
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Therapeutic potential of targeting group III metabotropic glutamate receptors as a disease modifying strategy in the treatment of Parkinson’s disease
… may underlie this continual degeneration of the nigrostriatal system. With this in mind, this thesis examined whether selective activation of group III metabotropic glutamate receptor subtypes may offer a novel strategy to halt persistent degeneration in PD.<br/><br/>Initial distribution studies …
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The effects of early developmental stress and exercise intervention on neurodegeneration in a rat model of Parkinson's disease
… involves the selective unilateral lesion of nigrostriatal dopamine neurons. In this group of studies it was hypothesized that maternal separation might enhance the toxic effects of 6-OHDA.
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An implantable piezoelectric ultrasound stimulator (ImPULS) for selective deep brain activation
… (SNc) to elicit time-locked modulation of nigrostriatal dopamine release. This work introduces a novel, non-genetic ultrasound platform for spatially localized neural stimulation.
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Roles of dopamine D1 and D2, opioid and glutamate NMDA receptor signaling in the acquisition and expression of fat- and glucose-conditioned flavor preferences in rats and c-Fos analysis of the dopamine mesotelencephalic and nigrostriatal pathways following intake of sugars and fats in rats
… that certain areas of the mesotelencephalic and nigrostriatal DA pathways affect CFP, such as the nucleus accumbens (NAc), the amygdala (AMY), the medial prefrontal cortex (mPFC), or the dorsal striatum (caudate and putamen: CPu). The present study examined the origin of DA (ventral tegmental …
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Investigating the role of neuroinflammation in a mouse model of L-Dopa induced dyskinesia and exploring the anti-dyskinetic potential of a cannabinoid receptor agonist
… to generate a consistent lesion of the nigrostriatal tract. Next, we assessed the neuroinflammatory profile in this mouse model, finding that mice with a dyskinetic phenotype displayed exacerbated neuroinflammatory responses when compared to naive and PD mice. In particular, dyskinetic …
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Effects of MPTP, MPP(+) and Adreno-Medullin on Dopamine Metabolism in the Rat Corpus Striatum
… primates produces selective destruction of the nigrostriatal dopamine neuron and severe motor impairments. That peripheral administration of a single substance selectively destroys the nigrostriatal dopaminergic system and produces symptoms and pathology comparable to parkinsonism has ignited a …
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TorsinA and the Pathophysiology of DYT1 Dystonia
… in torsinA mutant mice suggests that the nigrostriatal pathway may be a site of functional neuropathology in DYT1 dystonia. The relatively attenuated energy demand in basal ganglion output regions may be a manifestation of a primary functional abnormality in the nigrostriatal system of …
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Insecticide-Mediated Neurochemical and Behavioral Changes as Possible Predisposing Environmental Factors in Idiopathic Parkinson's Disease
… Disease, which results from degeneration of nigrostriatal neurons, along with reduced levels of the neurotransmitter, dopamine. Behavioral and neurochemical analyses in C57BL6 mice were performed following a subchronic dosing regime with the organochlorine insecticide heptachlor or the …
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The crossed mesostriatal pathway and circling behaviour in rats
Rats with unilateral 6-OHDA lesions of the nigrostriatal (NS) projection display motor asymmetry in the form of rotational behaviour. The rotation is in the direction ipsilateral with respect to the lesioned side (Ungerstedt 1979). The nett ipsilateral rotations decrease with time, from 1 week to …
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Sex and LRRK2 Genotype Differences in Inflammation and Dopaminergic Neurodegeneration in a Multi-Hit Model of Parkinson's Disease
… risk factors as they pertain to motor behaviour, nigrostriatal dopaminergic degeneration, and neuroinflammation. Moreover, since the male sex represents a significant risk factor in PD, sexual dimorphisms were addressed. To achieve this, male and female mice bearing the G2019S-LRRK2 mutation were …
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Separation and Detection of 2,3-Dihydroxybenzoic Acid
In Parkinson's disease, severe damage to nigrostriatal neurons causes a depletion of the neurotransmitter dopamine (DA). Oxidative stress on the brain is thought to contribute to neuron cell death and to the onset of Parkinson's disease. Reactive oxygen radicals produced during oxidative stress …
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Pathological changes in mesostriatal neurons in a PKC-gamma mutant rat
… impairments and progressive dysfunction of the nigrostriatal dopaminergic (DA) and raphe striatal serotonergic (5-HT) systems. The movement impairments including rigidity of the hind limbs, a staggering gait, a tendency to fall over every few steps, a slight whole body tremor and difficulty in …
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Η ΕΠΙΔΡΑΣΗ ΤΗΣ ΚΕΤΑΜΙΝΗΣ ΣΤΟ ΜΕΛΑΙΝΟΡΑΒΔΩΤΟ ΝΤΟΠΑΜΙΝΕΡΓΙΚΟ ΣΥΣΤΗΜΑ ΤΟΥ ΕΓΚΕΦΑΛΟΥ
… THE ACTION OF THE DOPAMINERGIC MECHANISMS IN THE NIGROSTRIATAL SYSTEM. THE ACTION OF THE OTHER DRUGS THAT WERE TESTED, AS WELL AS THE MODEOF THEIR ACTION IN THE STUDIED DOPAMINERGIC SYSTEM, IS DISCUSSED.
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Effect of maternal separation on stress-related proteins measured in a 6-hydroxydopamine rat model of Parkinson’s disease
… ELS has been shown to negatively affect the nigrostriatal pathway and mitochondrial function, developmental stress may create a vulnerable microenvironment which results in a greater rate of cell death during the development of PD. Many proteins play a role in establishing a positive …
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Neuromodulation and neural circuits underlying cognitive flexibility in the rat
… to simulate activity in the mesoaccumbal and nigrostriatal circuits during reversal learning. Here, activation of the mesoaccumbal, not nigrostriatal, circuit modulated reversal learning on trials when the expected reward was omitted. Taken together, these original results provide support for …
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