Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"Nifedipine"”.
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Utero-placental blood flow in hypertensive pregnancy and the effect of nifedipine administration
Nifedipine, in a 5mg sublingual acute administration, causes a significant fall in the systolic, diastolic and mean arterial pressure in a mixed group of pregnant hypertensives. A concurrent, significant rise in the pulse rate was seen. The utero-placental blood flow index, which is a measure of …
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The investigation of the calcium antagonist nifedipine on fetal umbilical artery Doppler waveforms
… will describe the investigation of the effect of nifedipine (a calcium antagonist) on the Doppler flow velocity waveform of the umbilical artery. The thesis is divided into two parts. The first section is a literature review of the three main aspects of the thesis namely: 1. The uteroplacental …
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ΜΕΛΕΤΕΣ ΠΑΝΩ ΣΤΗ ΦΑΡΜΑΚΟΛΟΓΙΚΗ ΘΕΡΑΠΕΙΑ ΤΗΣ ΑΧΑΛΑΣΙΑΣ ΤΟΥ ΟΙΣΟΦΑΓΟΥ. Ο ΡΟΛΟΣ ΤΩΝ ΑΝΤΑΓΩΝΙΣΤΩΝ ΤΟΥ ΑΣΒΕΣΤΙΟΥ
… WITH DLA CEBO THE EFFECTS OF VERAPAMIL AND NIFEDIPINE ON THE RESTING PRESSURE OF THE LOWER ESOPHAGEAL SPHINCTER AND THEAMPLITUDE OF CONTRACTION OF THE ESOPHAGEAL BODY USING MANOMETRY IN PATIENTS WITH ESOPHAGEAL ACHALASIA, AND TO DETERMINE THE EFFECTS OF THESE DRUGS ON THE CLINICAL …
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Crystal Engineering of Pharmaceuticals: Modulating Physicochemical Properties of Active Ingredients by the Formation of Cocrystals
… compounds considered are isoniazid, caffeine, nifedipine, glyburide, chlorpropamide and riboflavin. Co-formers selected are based on the suitability of functional groups for hydrogen bond formation. Co-crystal screening and preparation methods used include neat grinding (NG), liquid assisted …
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Ionic Conductivity in Non-Ionic Compounds
… like Lidocaine, Ketoconazole, Procainamide and Nifedipine were examined in this study. Experimental studies show an increase in ionic conductivity in both pre-melt (20 -30 °C below melting temperature) and melt transition regions. Results of ionic conductivity of both parallel plate and single …
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Nonsteroidal anti-inflammatory drugs and prostaglandin synthesis inhibitors in the treatment of urinary diseases and their effects on renal functions: clinical studies
… and by calcium antagonist (eg: sublingual nifedipine), could relieve acute or resistant renal colic and facilitate urinary calculus expulsion. The other aims of the thesis are to demonstrate the efficacy and safety of different methods of drug delivery as i.v, i.m, sublingual, oral or …
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Effect of Long-term Hypoxia on Myometrial Contractility in the Pregnant Sheep
… longitudinal myometrial strips were treated with nifedipine (L-type Ca<sup>2+</sup> channel blocker), ruthenium red, ryanodine (blockers of IPssensitive stores), 2-Nitro-4-carboxyphenyI-N,N-diphenyIcarbamate (NCDC; phospholipase C inhibitor), tetraethylammonium (TEA; nonspecific …
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Mechanisms of Ionophore Toxicoses: Laidlomycin Propionate Toxicosis in the Horse and Monensin, Laidlomycin, and Laidlomycin Propionate in Muscle Cultures
… cytotoxicity was not influenced by addition of nifedipine, verapamil, or magnesium.
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K+-Induced Smooth Muscle Calcium Sensitization Requires RhoA Kinase (ROK) Translocation to Caveolae Which Is Inhibited in Non-Neuronal Cell Memory
… not inhibited by Y-27632, but was abolished by nifedipine and the calmodulin blocker, trifluoperazine. Since, -30% of RhoA is colocalized with caveolin basally, these data suggest a novel model for Ca<sup>2+</sup>-activated Ca<sup>2+</sup>-sensitization, elicited by KC1 contraction, that …
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Pilot comparison of clinical effects and compliance with commonly prescribed antihypertensive drugs in HIV hypertensive patients at University Teaching Hospital
… side effects and better compliance. The use of Nifedipine ® in PLWHIV on NNRTIs should be carefully monitored as combinations with and Enalapril alone is less efficacious in hypertensive PLWHIV of African origin. Antihypertensive drug compliance improved by patient knowledge of hypertension …
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Pilot comparison of clinical effects and compliance with commonly prescribed antihypertensive drugs in HIV hypertensive patients at University Teaching Hospital
… side effects and better compliance. The use of Nifedipine ® in PLWHIV on NNRTIs should be carefully monitored as combinations with and Enalapril alone is less efficacious in hypertensive PLWHIV of African origin. Antihypertensive drug compliance improved by patient knowledge of hypertension …
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Small intestine slow wave activity defined through in vivo high-resolution electrical mapping
… porcine jejunum, before and after intra-arterial nifedipine administration to inhibit contractile movement, gastric extracellular recordings were simultaneously recorded using conventional serosal contact and suction electrodes, and biphasic and monophasic extracellular potentials were simulated …
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Functional ionic liquids in crystal engineering and drug delivery
… sulfathiazole, chlorpropamide, phenobarbital and nifedipine were investigated using imidazolium ionic liquids. The supramolecular complex of sulfathiazole and phenobarbital with imidazolium ionic liquids and polymorphic change in chlorpropamide was achieved. The ionic liquids provides unique …
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Age-associated changes to calcium handling proteins across the whole heart
… to isoprenaline, a β-adrenergic stimulator, and nifedipine. With age response to isoprenaline was diminished and SR Ca²⁺ cycling was established as crucial for pacemaker activity. Application of cylopiazonic acid profoundly reduced the response to isoprenaline in the younger age groups but had no …
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Function and pharmacology of TRPM3 ion channel
… and PIP2 all inhibited TRPM3, whereas nifedipine and elevated temperature activated the channel. TRPM3 appears to be regulated by a large number of different chemicals and mechanisms. In summary, TRPM3 has constitutive, protective, activity which can be suppressed by a multitude of …
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Predicting Vision Loss In Healthy Aging With Manganese-Enhanced Mri Of The Rat Eye
… and topical application of the L-VGCC antagonist nifedipine, and discovered an age-related change in sensitivity to L-VGCC blocker diltiazem. Based on Western blot studies, we find this sensitivity change to be consistent with the age-dependant appearance of drug-insensitive L-VGCC isoforms. …
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Studies on the role of the autonomic nervous system in airway hyperreactivity.
… - channel (VDC) blocking drugs, verapamil and nifedipine, attenuated responses to applied ACh and stimulation of the vagus nerve in untreated tissues, indicating significant VDC involvement in the production of spontaneous and evoked tone. The calmodulin antagonist, trifluoperazine (TFP), also …
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CaV1.3 Ion channel expression and hormone therapy in prostate cancer
… calcium responses in a subpopulation of cells. Nifedipine-induced inhibition of CaV1.3 in ENZ-treated LNCaP cells appeared to increase apoptosis, albeit not significantly, compared to ENZ treatment alone. Investigation of trafficking mechanisms of CaV1.3 showed that plasma membrane surface …
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Sensory Transduction in Enteroendocrine Cells
… voltage gated sodium current and a nifedipine-sensitive persistent calcium current.<br/>In intracellular calcium studies of STC-1 cells, the TRPA1 agonists cinnamaldehyde and AITC evoked increases in intracellular calcium concentration that could be inhibited by the TRPA1 antagonist …
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