Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Nidogen"”.
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Nidogen-1 and Nidogen-2 in healthy human cartilage and in late-stage osteoarthritis cartilage
… des Vorkommens und der Funktionen von Nidogen-1 und Nidogen-2 in gesundem humanem Knorpel und in den späten Stadien der Osteoarthritis. Methoden: Die Lokalisierung und Quantifizierung beider Nidogene im Knorpel, sowohl auf Protein als auch auf mRNA-Ebene, wurde mittels gesunden Spendern …
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The nidogen-domain protein DEX-1 is necessary for the Caenorhabditis elegans dauer morphology and behavior
… understood. This work provides evidence that the nidogen domain-containing protein DEX-1 facilitates the stage-specific tissue remodeling observed during dauer morphogenesis. DEX-1 was previously shown to function as a secreted extracellular matrix protein that regulates sensory dendrite formation …
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Antiangiogenic and proteolytic activities of prostate-specific antigen
… than any other protein substrate studied. Nidogen-1, a component of the basement membrane, was identified as a novel substrate for PSA by mass spectrometry. However, the cleavage of nidogen-1 did not explain the antiangiogenic activity of PSA, since either its fragments or full-length form …
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Mechanisms of Type IV Collagen Targeting to Developing Basement Membranes
… explore the roles of the matricellular proteins nidogen, agrin, perlecan, and SPARC in the targeting of collagen to pharyngeal and gonadal BMs. In Chapter 4, I identify potentially novel regulators of type IV collagen incorporation into BMs through a genome-scale RNAi screen. Finally, in Chapter …
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Exploring Polarized Membrane Protein Distribution in Drosophila Follicle Cells using Proximity Labelling
… Using HRP-tagged Cadherin99c, Fasciclin 3, and Nidogen as apical, lateral, and basal baits respectively, I identified several membrane-domain specific transmembrane hits through mass spectrometry. Toll7 and Arrow were two interesting candidates that showed a basal staining in the follicle cells. …
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Identifizierung und Charakterisierung von AST-1 in C. elegans, einem ETS Transkriptionsfaktor, der die axonale Wegfindung reguliert
… und die extrazelluläre Matrixkomponente Nidogen. AST-1 könnte direkt die Expression von Genen steuern, die für Signalmoleküle oder Rezeptoren des axonalen Auswachsens kodieren, wobei die Zielgene bisher noch nicht identifiziert wurden. AST-1 reguliert sowohl in der neuronalen …